| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Kwon H. Deborah (日) (読)
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| 2. | 楠瀬 賢也
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| 3. | (英) Obuchowski A. Nancy (日) (読)
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| 4. | (英) Cavalcante L. João (日) (読)
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| 5. | (英) Popovic B. Zoran (日) (読)
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| 6. | (英) Thomas D. James (日) (読)
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| 7. | (英) Desai Y. Milind (日) (読)
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| 8. | (英) Flamm D. Scott (日) (読)
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| 9. | (英) Griffin P. Brian (日) (読)
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| ○題名 (必須): | □ | (英) Predictors and Prognostic Impact of Progressive Ischemic Mitral Regurgitation in Patients With Advanced Ischemic Cardiomyopathy: A Multimodality Study. (日)
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| ○要約 (任意): | □ | (英) Ischemic mitral regurgitation (IMR) is associated with poor outcomes. It is unknown what factors contribute to progression of IMR and how progressive IMR affects outcomes. We sought to determine imaging predictors of IMR progression and to determine if progressive IMR is an independent predictor of survival in patients with advanced ischemic cardiomyopathy. Consecutive advanced ischemic cardiomyopathy patients who underwent cardiac magnetic resonance and echocardiograms at baseline with echocardiographic follow-up were studied. Cardiac magnetic resonance was used to assess left ventricular volumes, infarct size, and mitral valve geometry. The effective regurgitant orifice area (EROA) was calculated from the proximal isovelocity surface area by echocardiography. Repeated measures mixed effects and Cox proportional hazards regression models were built to identify predictors of IMR progression and survival. We evaluated 336 patients (age, 62±11 years) over a median follow-up time of 54 months: 154 patients were subsequently revascularized, and 182 patients were medically treated. Ninety-eight patients (29%) demonstrated an increase in EROA values of ≥0.1 cm(2). There were 87 adverse events (death or transplant). On multivariable analysis, infarct size (P<0.001), progression in IMR (P=0.008), age (P=0.003), and baseline EROA (P=0.010) were independently associated with adverse events. Independent predictors of IMR progression were as follows: baseline EROA (P<0.001), left ventricular end-systolic volume index (P=0.014), and total scar (P=0.036). IMR frequently increases in severity, and progression is independently associated with adverse left ventricular remodeling and infarct size, as assessed by cardiac magnetic resonance. Furthermore, IMR progression is a powerful independent predictor of adverse events, even after controlling for the severity of IMR at baseline. (日)
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| ○キーワード (推奨): | 1. | (英) Aged (日) (読)
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| 2. | (英) Cardiomyopathies (日) (読)
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| 3. | (英) Chi-Square Distribution (日) (読)
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| 4. | (英) Coronary Stenosis (日) (読)
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| 5. | (英) Disease Progression (日) (読)
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| 6. | (英) Echocardiography (日) (読)
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| 7. | (英) Female (日) (読)
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| 8. | (英) Humans (日) (読)
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| 9. | (英) Image Interpretation, Computer-Assisted (日) (読)
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| 10. | (英) Magnetic Resonance Imaging, Cine (日) (読)
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| 11. | (英) Male (日) (読)
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| 12. | (英) Middle Aged (日) (読)
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| 13. | (英) Mitral Valve Insufficiency (日) (読)
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| 14. | マルチモーダルイメージング (multimodal imaging)
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| 15. | (英) Multivariate Analysis (日) (読)
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| 16. | (英) Myocardial Infarction (日) (読)
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| 17. | 心筋 (myocardium)
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| 18. | (英) Observer Variation (日) (読)
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| 19. | (英) Predictive Value of Tests (日) (読)
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| 20. | (英) Prognosis (日) (読)
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| 21. | (英) Proportional Hazards Models (日) (読)
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| 22. | (英) Reproducibility of Results (日) (読)
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| 23. | (英) Retrospective Studies (日) (読)
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| 24. | (英) Risk Factors (日) (読)
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| 25. | (英) Severity of Illness Index (日) (読)
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| 26. | (英) Stroke Volume (日) (読)
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| 27. | (英) Time Factors (日) (読)
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| 28. | (英) Ventricular Function, Left (日) (読)
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| 29. | (英) Ventricular Remodeling (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Circulation. Cardiovascular Imaging ([American Heart Association])
(pISSN: 1941-9651, eISSN: 1942-0080)
| ○ISSN (任意): | □ | 1942-0080
ISSN: 1941-9651
(pISSN: 1941-9651, eISSN: 1942-0080) Title: Circulation. Cardiovascular imagingTitle(ISO): Circ Cardiovasc ImagingPublisher: American Heart Association (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 9
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| ○号 (必須): | □ | 7
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| ○頁 (必須): |
| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2016年 7月 初日 (平成 28年 7月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1161/CIRCIMAGING.115.004577 (→Scopusで検索)
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| ○PMID (任意): | □ | 27406842 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS (任意): |
| ○Scopus (任意): | □ | 2-s2.0-84978971718
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| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1161/CIRCIMAGING.115.004577 (日)
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| 2. | (英) Article.ELocationID: e004577 (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 4. | (英) Article.PublicationTypeList.PublicationType: Observational Study (日)
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| 5. | (英) KeywordList.Keyword: echocardiography (日)
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| 6. | (英) KeywordList.Keyword: magnetic resonance imaging (日)
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| 7. | (英) KeywordList.Keyword: mitral valve (日)
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| 8. | (英) KeywordList.Keyword: myocardial infarction (日)
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