『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
ID: Pass:

登録内容 (EID=325977)

EID=325977EID:325977, Map:0, LastModified:2017年9月11日(月) 16:17:30, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[高浜 洋介], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Takada Kensuke (日) 高田 健介 (読) たかだ けんすけ
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2.近藤 健太
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
3.高浜 洋介
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Generation of Peptides That Promote Positive Selection in the Thymus  (日)    [継承]
副題 (任意):
要約 (任意): (英) To establish an immunocompetent TCR repertoire that is useful yet harmless to the body, a de novo thymocyte repertoire generated through the rearrangement of genes that encode TCR is shaped in the thymus through positive and negative selection. The affinity between TCRs and self-peptides associated with MHC molecules determines the fate of developing thymocytes. Low-affinity TCR engagement with self-peptide-MHC complexes mediates positive selection, a process that primarily occurs in the thymic cortex. Massive efforts exerted by many laboratories have led to the characterization of peptides that can induce positive selection. Moreover, it is now evident that protein degradation machineries unique to cortical thymic epithelial cells play a crucial role in the production of MHC-associated self-peptides for inducing positive selection. This review summarizes current knowledge on positive selection-inducing self-peptides and Ag processing machineries in cortical thymic epithelial cells. Recent studies on the role of positive selection in the functional tuning of T cells are also discussed.  (日)    [継承]
キーワード (推奨):
発行所 (推奨):
誌名 (必須): The Journal of Immunology ([The American Association of Immunologists])
(pISSN: 0022-1767, eISSN: 1550-6606)

ISSN (任意): 1550-6606
ISSN: 0022-1767 (pISSN: 0022-1767, eISSN: 1550-6606)
Title: Journal of immunology (Baltimore, Md. : 1950)
Title(ISO): J Immunol
Publisher: American Association of Immunologists
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
[継承]
[継承]
(必須): 198 [継承]
(必須): 6 [継承]
(必須): 2215 2222 [継承]
都市 (任意):
年月日 (必須): 西暦 2017年 3月 15日 (平成 29年 3月 15日) [継承]
URL (任意):
DOI (任意): 10.4049/jimmunol.1601862    (→Scopusで検索) [継承]
PMID (任意): 28264997    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意):
Scopus (任意):
評価値 (任意):
被引用数 (任意):
指導教員 (推奨):
備考 (任意): 1.(英) Article.ELocationID: 10.4049/jimmunol.1601862  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Review  (日)    [継承]

標準的な表示

和文冊子 ● Kensuke Takada, Kenta Kondou and Yousuke Takahama : Generation of Peptides That Promote Positive Selection in the Thymus, The Journal of Immunology, Vol.198, No.6, 2215-2222, 2017.
欧文冊子 ● Kensuke Takada, Kenta Kondou and Yousuke Takahama : Generation of Peptides That Promote Positive Selection in the Thymus, The Journal of Immunology, Vol.198, No.6, 2215-2222, 2017.

関連情報

Number of session users = 0, LA = 0.23, Max(EID) = 383285, Max(EOID) = 1024421.