『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=325806EID:325806, Map:0, LastModified:2018年11月29日(木) 11:56:32, Operator:[[ADMIN]], Avail:TRUE, Censor:0, Owner:[佐田 政隆], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨): 単独著作 (徳島大学内の単一の研究グループ(研究室等)内の研究 (単著も含む)) [継承]
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Bando S (日) 坂東 左知子 (読) ばんどう さちこ
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学籍番号 (推奨): **** [ユーザ]
[継承]
2.添木 武 ([徳島大学.大学院医歯薬学研究部.医学域.連携研究部門(医学域).寄附講座系(医学域).実践地域診療・医科学])
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学籍番号 (推奨):
[継承]
3.松浦 朋美 ([徳島大学.病院.先端医科医療開発研究プロジェクト]/[徳島大学.病院.診療科.内科.循環器内科])
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[継承]
4.飛梅 威
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[継承]
5.伊勢 孝之 ([徳島大学.病院.診療科.内科.循環器内科])
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[継承]
6.楠瀬 賢也 ([徳島大学.病院.診療科.内科.循環器内科])
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[継承]
7.山口 浩司 ([徳島大学.病院.診療科.内科.循環器内科])
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[継承]
8.八木 秀介 ([徳島大学.大学院医歯薬学研究部.医学域.連携研究部門(医学域).寄附講座系(医学域).地域医療人材育成(医学域)])
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[継承]
9.福田 大受
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[継承]
10.岩瀬 俊
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[継承]
11.山田 博胤 ([徳島大学.大学院医歯薬学研究部.医学域.連携研究部門(医学域).寄附講座系(医学域).地域循環器内科学])
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[継承]
12.若槻 哲三 ([徳島大学.大学院医歯薬学研究部.医学域.先端医学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.循環器内科学]/[徳島大学.病院.診療科.内科.循環器内科])
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[継承]
13.島袋 充生
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[継承]
14.六車 直樹
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[継承]
15.高山 哲治 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.消化器内科学])
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[継承]
16. (英) Kishimoto I (日) (読)
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[継承]
17.寒川 賢治 (国立循環器病センター研究所)
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[継承]
18.佐田 政隆 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.循環器内科学])
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[継承]
題名 (必須): (英) Plasma brain natriuretic peptide levels are elevated in patients with cancer  (日)    [継承]
副題 (任意):
要約 (任意): (英) Natriuretic peptides have been proposed as biomarkers of cardiovascular disease, especially heart failure. Brain natriuretic peptide (BNP) has also been shown to be upregulated at the transcriptional and translational levels by pro-inflammatory cytokines in cardiac myocytes. Although we often measure plasma BNP levels in cancer patients, it remains unknown whether cancer-related inflammation affects the plasma BNP levels. We investigated the relationship between the BNP and human cancers. We retrospectively studied 2,923 patients in whom the plasma BNP levels and serum C-reactive protein (CRP) were measured and echocardiography was performed. Patients with clinically evident heart failure (NYHA II or higher), heart disease requiring medical treatment or surgery, renal dysfunction, and inflammatory disease were excluded. There were 234 patients in the final analysis. Blood sampling was performed before surgery and chemotherapy. In addition, we evaluated the relationship between the inflammation and plasma BNP levels in mouse models of colon cancer. Of the 234 patients, 80 were diagnosed with cancer. Both the plasma BNP and serum CRP levels were significantly higher in cancer patients than those without. There were no significant differences in the echocardiographic parameters. There was a significant positive correlation between the plasma BNP and serum CRP levels in cancer patients (r = 0.360, P<0.01) but not in those without. In cancer patients, only the CRP correlated with the BNP independent of the age, creatinine level, hypertension, and body mass index. In addition, in nude mice with subcutaneous colon cancer, the plasma BNP level was elevated compared with that in non-cancer mice, and there was a significant relationship between the plasma BNP and serum levels of the inflammatory markers. In cancer patients, as well as colon cancer model mice, the plasma BNP levels were elevated, possibly due to cancer-related inflammation. The effect of cancer on the BNP levels should be considered when using BNP as an indicator of heart failure in cancer patients.  (日)    [継承]
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誌名 (必須): PLoS ONE (Public Library of Science)
(eISSN: 1932-6203)

ISSN (任意): 1932-6203
ISSN: 1932-6203 (eISSN: 1932-6203)
Title: PloS one
Title(ISO): PLoS One
Publisher: PLOS
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 12 [継承]
(必須): 6 [継承]
(必須): e0178607 e0178607 [継承]
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年月日 (必須): 西暦 2017年 6月 1日 (平成 29年 6月 1日) [継承]
URL (任意):
DOI (任意): 10.1371/journal.pone.0178607    (→Scopusで検索) [継承]
PMID (任意): 28570595    (→Scopusで検索) [継承]
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機関リポジトリ : 112318 [継承]
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備考 (任意): 1.(英) Article.ELocationID: 10.1371/journal.pone.0178607  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● S Bando, Takeshi Soeki, Tomomi Matsuura, Takeshi Tobiume, Takayuki Ise, Kenya Kusunose, Koji Yamaguchi, Shusuke Yagi, Daiju Fukuda, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro, Naoki Muguruma, Tetsuji Takayama, I Kishimoto, Kenji Kangawa and Masataka Sata : Plasma brain natriuretic peptide levels are elevated in patients with cancer, PLoS ONE, Vol.12, No.6, e0178607, 2017.
欧文冊子 ● S Bando, Takeshi Soeki, Tomomi Matsuura, Takeshi Tobiume, Takayuki Ise, Kenya Kusunose, Koji Yamaguchi, Shusuke Yagi, Daiju Fukuda, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro, Naoki Muguruma, Tetsuji Takayama, I Kishimoto, Kenji Kangawa and Masataka Sata : Plasma brain natriuretic peptide levels are elevated in patients with cancer, PLoS ONE, Vol.12, No.6, e0178607, 2017.

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