| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): | □ | Peer Review
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| ○カテゴリ (推奨): | □ | 研究
| [継承] |
| ○共著種別 (推奨): | □ | 単独著作 (徳島大学内の単一の研究グループ(研究室等)内の研究 (単著も含む))
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| ○学究種別 (推奨): | □ | 博士課程学生による研究報告
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| ○組織 (推奨): | 1. | 徳島大学.口腔科学研究科 (2004年4月1日〜)
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| 2. | 徳島大学.歯学部
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| ○著者 (必須): | 1. | Hutami Islamy Rahma ([徳島大学.口腔科学研究科.口腔科学専攻.口腔健康科学講座.口腔顎顔面矯正学])
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): | □ | ****
| [ユーザ] |
| [継承] |
| 2. | 井澤 俊
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 3. | 三野 彰子 ([徳島大学.口腔科学研究科.口腔科学専攻.口腔健康科学講座.口腔顎顔面矯正学])
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 4. | 篠原 丈裕 ([徳島大学.口腔科学研究科.口腔科学専攻.口腔健康科学講座.口腔顎顔面矯正学])
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 5. | 森 浩喜
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 6. | 岩浅 亮彦
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 7. | 田中 栄二 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.口腔顎顔面矯正学])
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| ○題名 (必須): | □ | (英) Fas/S1P1 crosstalk via NF-B activation in osteoclasts controls subchondral bone remodeling in murine TMJ arthritis (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Enhanced turnover of subchondral trabecular bone is a hallmark of rheumatoid arthritis (RA) and it results from an imbalance between bone resorption and bone formation activities. To investigate the formation and activation of osteoclasts which mediate bone resorption, a Fas-deficient MRL/lpr mouse model which spontaneously develops autoimmune arthritis and exhibits decreased bone mass was studied. Various assays were performed on subchondral trabecular bone of the temporomandibular joint (TMJ) from MRL/lpr mice and MRL+/+ mice. Initially, greater osteoclast production was observed in vitro from bone marrow macrophages obtained from MRL/lpr mice due to enhanced phosphorylation of NF-B, as well as Akt and MAPK, to receptor activator of nuclear factor-B ligand (RANKL). Expression of sphingosine 1-phosphate receptor 1 (S1P1) was also significantly upregulated in the condylar cartilage. S1P1 was found to be required for S1P-induced migration of osteoclast precursor cells and downstream signaling via Rac1. When SN50, a synthetic NF-B-inhibitory peptide, was applied to the MRL/lpr mice, subchondral trabecular bone loss was reduced and both production of osteoclastogenesis markers and sphingosine kinase (Sphk) 1/S1P1 signaling were reduced. Thus, the present results suggest that Fas/S1P1 signaling via activation of NF-B in osteoclast precursor cells is a key factor in the pathogenesis of RA in the TMJ. (日)
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| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
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| 2. | (英) Antigens, CD95 (日) (読)
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| 3. | (英) Arthritis, Rheumatoid (日) (読)
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| 4. | (英) Autoimmunity (日) (読)
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| 5. | (英) Bone Marrow Cells (日) (読)
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| 6. | (英) Bone Resorption (日) (読)
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| 7. | (英) Cell Differentiation (日) (読)
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| 8. | (英) Disease Models, Animal (日) (読)
| [継承] |
| 9. | (英) Female (日) (読)
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| 10. | (英) Gene Expression Regulation (日) (読)
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| 11. | (英) Lysophospholipids (日) (読)
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| 12. | (英) Macrophages (日) (読)
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| 13. | (英) Mice (日) (読)
| [継承] |
| 14. | (英) Mice, Inbred MRL lpr (日) (読)
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| 15. | (英) Mitogen-Activated Protein Kinases (日) (読)
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| 16. | (英) NF-kappa B (日) (読)
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| 17. | (英) Neuropeptides (日) (読)
| [継承] |
| 18. | (英) Osteoclasts (日) (読)
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| 19. | (英) Osteogenesis (日) (読)
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| 20. | (英) Peptides (日) (読)
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| 21. | (英) Phosphotransferases (Alcohol Group Acceptor) (日) (読)
| [継承] |
| 22. | (英) Primary Cell Culture (日) (読)
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| 23. | (英) Proto-Oncogene Proteins c-akt (日) (読)
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| 24. | (英) RANK Ligand (日) (読)
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| 25. | (英) Receptors, Lysosphingolipid (日) (読)
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| 26. | (英) Signal Transduction (日) (読)
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| 27. | (英) Sphingosine (日) (読)
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| 28. | (英) Temporomandibular Joint (日) (読)
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| 29. | (英) rac1 GTP-Binding Protein (日) (読)
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| ○発行所 (推奨): | □ | Elsevier Science B.V.
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| ○誌名 (必須): | □ | Biochemical and Biophysical Research Communications ([Elsevier])
(pISSN: 0006-291X, eISSN: 1090-2104)
| ○ISSN (任意): | □ | 1090-2104
ISSN: 0006-291X
(pISSN: 0006-291X, eISSN: 1090-2104) Title: Biochemical and biophysical research communicationsTitle(ISO): Biochem Biophys Res CommunPublisher: Elsevier B.V. (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 490
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| ○号 (必須): | □ | 4
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| ○頁 (必須): | □ | 1274 1281
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2017年 9月 2日 (平成 29年 9月 2日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1016/j.bbrc.2017.07.006 (→Scopusで検索)
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| ○PMID (任意): | □ | 28687489 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS (任意): |
| ○Scopus (任意): |
| ○評価値 (任意): |
| ○被引用数 (任意): |
| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) Article.ELocationID: S0006-291X(17)31337-2 (日)
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| 2. | (英) Article.ELocationID: 10.1016/j.bbrc.2017.07.006 (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 4. | (英) KeywordList.Keyword: Fas (日)
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| 5. | (英) KeywordList.Keyword: Osteoclast (日)
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| 6. | (英) KeywordList.Keyword: S1P(1) (日)
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| 7. | (英) KeywordList.Keyword: SN50 (日)
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| 8. | (英) KeywordList.Keyword: Temporomandibular joint (日)
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