| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○審査 (推奨): |
| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | 北村 晋志
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| 2. | 棚橋 俊仁
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| 3. | (英) Aoyagi Eriko (日) (読)
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| 4. | 中川 忠彦
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| 5. | 岡本 耕一 ([徳島大学.病院.診療科.内科.消化器内科])
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| 6. | 木村 哲夫
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| 7. | 宮本 弘志 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.消化器内科学]/[徳島大学.病院.診療科.内科.消化器内科])
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| 8. | 三井 康裕 ([徳島大学.大学院医歯薬学研究部.医学域.先端医学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.消化器内科学])
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| 9. | 六反 一仁
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| 10. | 六車 直樹
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| 11. | 高山 哲治 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.消化器内科学])
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| ○題名 (必須): | □ | (英) Response Predictors of S-1, Cisplatin, and Docetaxel Combination Chemotherapy for Metastatic Gastric Cancer: Microarray Analysis of Whole Human Genes. (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) The aim of this study was to identify biomarkers for predicting the efficacy of docetaxel, cisplatin, and S-1 (DCS) therapy for advanced gastric cancer using microarrays of biopsy specimens before chemotherapy. Nineteen samples were taken from 19 patients with unresectable metastatic gastric cancer who received DCS as a first-line therapy. Laser capture microdissection was performed, and total cellular RNA was extracted from each microdissected sample. Whole-gene expression was analyzed by microarray, and the difference in mRNA expression observed with the microarrays was confirmed by quantitative real-time PCR. Immunohistochemical staining was performed using clinical tissue sections obtained by endoscopic biopsy. Eleven patients were identified as early responders and 8 patients as nonresponders to DCS therapy. Twenty-nine genes showed significant differences in relative expression ratios between tumor and normal tissues. A classifier set of 29 genes had high accuracy (94.7%) for distinguishing gene expression between 11 early responders and 8 nonresponders. Decreasing the size of the classifier set to 4 genes (PDGFB, PCGF3, CISH, and ANXA5) increased the accuracy to 100%. Expression levels by real-time PCR for validation were well correlated with those 4 genes in microarrays. The genes identified may serve as efficient biomarkers for personalized cancer-targeted therapy. (日)
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| ○キーワード (推奨): |
| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Oncology (S. Karger AG, Basel)
(pISSN: 0030-2414, eISSN: 1423-0232)
| ○ISSN (任意): | □ | 1423-0232
ISSN: 0030-2414
(pISSN: 0030-2414, eISSN: 1423-0232) Title: OncologyTitle(ISO): OncologyPublisher: S. Karger AG (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 93
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| ○号 (必須): | □ | 2
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| ○頁 (必須): | □ | 127 135
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2017年 5月 17日 (平成 29年 5月 17日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1159/000464329 (→Scopusで検索)
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| ○PMID (任意): | □ | 28511180 (→Scopusで検索)
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| ○CRID (任意): |
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| ○Scopus (任意): | □ | 2-s2.0-85019884830
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| ○機関リポジトリ : | □ | 111015
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| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1159/000464329 (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) KeywordList.Keyword: Chemotherapy (日)
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| 4. | (英) KeywordList.Keyword: Gastric cancer (日)
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| 5. | (英) KeywordList.Keyword: Microarray (日)
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