| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 日本語
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| ○招待 (推奨): |
| ○審査 (推奨): | □ | Peer Review
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| ○カテゴリ (推奨): | □ | 研究
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| ○共著種別 (推奨): | □ | 国内共著 (徳島大学内研究者と国内(学外)研究者との共同研究 (国外研究者を含まない))
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| ○学究種別 (推奨): | □ | 博士後期課程学生による研究報告
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| ○組織 (推奨): | 1. | 徳島大学
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| ○著者 (必須): | 1. | 長谷 栄治 ([徳島大学.ポストLEDフォトニクス研究所])
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| 2. | 南川 丈夫
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| 3. | 佐藤 克也 ([徳島大学.大学院社会産業理工学研究部.理工学域.機械科学系.知能機械学分野]/[徳島大学.理工学部.理工学科.機械科学コース.知能機械学講座])
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| 4. | 米倉 大介 ([徳島大学.大学院社会産業理工学研究部.理工学域.機械科学系.生産工学分野]/[徳島大学.理工学部.理工学科.機械科学コース.生産工学講座])
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| 5. | 高橋 光彦
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| 6. | 安井 武史 ([徳島大学.ポストLEDフォトニクス研究所]/[徳島大学.理工学部.理工学科.機械科学コース.生産工学講座])
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| ○題名 (必須): | □ | (英) Observation of Tendon Healing with Second-harmonic-generation (SHG) Microscopy (日) 第2高調波発生光(SHG)顕微鏡を用いた腱修復の観察
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| ○要約 (任意): | □ | (英) <p>Tendon rupture is a traumatic injury that is difficult to recover to the condition before injury. In previous studies, histological staining and tensile testing have been widely used to evaluate histological and mechanical healing. However, since both methods are destructive and invasive, it is difficult to apply these methods to clinical diagnosis. If the degree of healing can be visualized nondestructively and noninvasively, new findings may be obtained regarding mechanisms of the tendon healing process. In this study, we used second-harmonic-generation (SHG) microscopy to evaluate the degree of healing of ruptured tendon in a rabbit model. SHG microscopy has high selectivity and high image contrast with respect to the structural maturity, density, and aggregates of collagen molecule, without the need for histological sectioning and staining. Furthermore, since SHG light intensity sensitively reflects the structural maturity of collagen molecule and its aggregates, it has the potential to be a good indicator for the degree of healing of the injured tendon. By comparing the SHG images between 4-week-healing tendons and normal tendons in the animal model, we confirmed that SHG light intensity of the healing tendon was significantly lower than that of the normal tendon, indicating that the collagen structure in the healing tendon is still immature. Furthermore, we performed image analysis based on 2D Fourier transform of the acquired SHG images, and confirmed a significant difference in collagen distribution depending on the sample. These results indicate that SHG microscopy has the unique potential as an indicator of tendon healing.</p> (日)
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| ○キーワード (推奨): | 1. | (英) second-harmonic-generation (日) (読)
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| 2. | (英) microscopy (日) (読)
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| 3. | (英) tendon (日) (読)
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| 4. | (英) collagen (日) (読)
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| 5. | (英) healing (日) (読)
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| 6. | (英) image analysis (日) (読)
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| ○発行所 (推奨): | □ | 社団法人 日本生体医工学会 (->組織[日本ME学会])
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| ○誌名 (必須): | □ | 生体医工学 ([日本ME学会])
(pISSN: 1347-443X, eISSN: 1881-4379)
| ○ISSN (任意): | □ | 1347-443X
ISSN: 1347-443X
(pISSN: 1347-443X, eISSN: 1881-4379) Title: 生体医工学 : 日本エム・イー学会誌Supplier: 社団法人日本生体医工学会Publisher: Japanese Society for Medical and Biological Engineering (Webcat Plus)
(医中誌Web)
(J-STAGE)
(Scopus)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 54
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| ○号 (必須): | □ | 6
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| ○頁 (必須): | □ | 253 260
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| ○年月日 (必須): | □ | 西暦 2016年 12月 初日 (平成 28年 12月 初日)
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| ○URL (任意): | □ | http://id.ndl.go.jp/bib/027992837
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| ○DOI (任意): | □ | 10.11239/jsmbe.54.253 (→Scopusで検索)
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| ○PMID (任意): |
| ○CRID (任意): | □ | 1390001205270574720
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| ○NAID : | □ | 130005450576
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