『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=323167EID:323167, Map:0, LastModified:2017年4月15日(土) 19:27:15, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[岡村 裕彦], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨): 招待 [継承]
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨): 国内共著 (徳島大学内研究者と国内(学外)研究者との共同研究 (国外研究者を含まない)) [継承]
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著者 (必須): 1.岡村 裕彦
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2.吉田 賀弥 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.口腔保健学系.口腔保健教育学]/[徳島大学.歯学部.口腔保健学科.口腔保健基礎学講座])
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3.森本 景之
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4.寺町 順平
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5.落合 和彦
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6.羽地 達次
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7.山本 朗仁 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.組織再生制御学])
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題名 (必須): (英) Role of Protein Phosphatase 2A in Osteoblast Differentiation and Function.  (日)    [継承]
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要約 (任意): (英) The reversible phosphorylation of proteins plays hugely important roles in a variety of cellular processes, such as differentiation, proliferation, and apoptosis. These processes are strictly controlled by protein kinases (phosphorylation) and phosphatases (de-phosphorylation). Here we provide a brief history of the study of protein phosphorylation, including a summary of different types of protein kinases and phosphatases. One of the most physiologically important serine/threonine phosphatases is PP2A. This review provides a description of the phenotypes of various PP2A transgenic mice and further focuses on the known functions of PP2A in bone formation, including its role in osteoblast differentiation and function. A reduction in PP2A promotes bone formation and osteoblast differentiation through the regulation of bone-related transcription factors such as Osterix. Interestingly, downregulation of PP2A also stimulates adipocyte differentiation from undifferentiated mesenchymal cells under the appropriate adipogenic differentiation conditions. In osteoblasts, PP2A is also involved in the ability to control osteoclastogenesis as well as in the proliferation and metastasis of osteosarcoma cells. Thus, PP2A is considered to be a comprehensive factor in controlling the differentiation and function of cells derived from mesenchymal cells such as osteoblasts and adipocytes.  (日)    [継承]
キーワード (推奨): 1.骨芽細胞 (osteoblast) [継承]
2.蛋白質脱リン酸化 (protein dephosphorylation) [継承]
3.プロテインフォスファターゼ (protein phosphatase) [継承]
発行所 (推奨):
誌名 (必須): Journal of Clinical Medicine (MDPI AG)
(eISSN: 2077-0383)

ISSN (任意): 2077-0383
ISSN: 2077-0383 (eISSN: 2077-0383)
Title: Journal of clinical medicine
Title(ISO): J Clin Med
Publisher: MDPI AG
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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年月日 (必須): 西暦 2017年 2月 23日 (平成 29年 2月 23日) [継承]
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DOI (任意): 10.3390/jcm6030023    (→Scopusで検索) [継承]
PMID (任意): 28241467    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.ELocationID: E23  (日)    [継承]
2.(英) Article.ELocationID: 10.3390/jcm6030023  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
4.(英) Article.PublicationTypeList.PublicationType: Review  (日)    [継承]
5.(英) KeywordList.Keyword: adipogenesis  (日)    [継承]
6.(英) KeywordList.Keyword: bone formation  (日)    [継承]
7.(英) KeywordList.Keyword: osteoblast differentiation  (日)    [継承]
8.(英) KeywordList.Keyword: osteoclastogenesis  (日)    [継承]
9.(英) KeywordList.Keyword: osteosarcoma cells  (日)    [継承]
10.(英) KeywordList.Keyword: protein phosphatase  (日)    [継承]

標準的な表示

和文冊子 ● Hirohiko Okamura, Kaya Yoshida, Hiroyuki Morimoto, Jumpei Teramachi, Kazuhiko Ochiai, Tatsuji Haneji and Akihito Yamamoto : Role of Protein Phosphatase 2A in Osteoblast Differentiation and Function., Journal of Clinical Medicine, Vol.6, No.3, (頁), 2017.
欧文冊子 ● Hirohiko Okamura, Kaya Yoshida, Hiroyuki Morimoto, Jumpei Teramachi, Kazuhiko Ochiai, Tatsuji Haneji and Akihito Yamamoto : Role of Protein Phosphatase 2A in Osteoblast Differentiation and Function., Journal of Clinical Medicine, Vol.6, No.3, (頁), 2017.

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