『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
ID: Pass:

登録内容 (EID=322896)

EID=322896EID:322896, Map:0, LastModified:2020年4月20日(月) 18:44:49, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[福井 清], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨): 単独著作 (徳島大学内の単一の研究グループ(研究室等)内の研究 (単著も含む)) [継承]
学究種別 (推奨):
組織 (推奨): 1.次世代酵素学研究領域 (2016年4月1日〜2020年3月31日) [継承]
著者 (必須): 1.加藤 有介
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2.福井 清 ([徳島大学])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Structure models of G72, the product of a susceptibility gene to schizophrenia  (日)    [継承]
副題 (任意):
要約 (任意): (英) The G72 gene is one of the most susceptible genes to schizophrenia and is contained exclusively in the genomes of primates. The product of the G72 gene modulates the activity of D-amino acid oxidase (DAO) and is a small protein prone to aggregate, which hampers its structural studies. In addition, lack of a known structure of a homologue makes it difficult to use the homology modelling method for the prediction of the structure. Thus, we first developed a hybrid ab initio approach for small proteins prior to the prediction of the structure of G72. The approach uses three known ab initio algorithms. To evaluate the hybrid approach, we tested our prediction of the structure of the amino acid sequences whose structures were already solved and compared the predicted structures with the experimentally solved structures. Based on these comparisons, the average accuracy of our approach was calculated to be ∼5 Å. We then applied the approach to the sequence of G72 and successfully predicted the structures of the N- and C-terminal domains (ND and CD, respectively) of G72. The predicted structures of ND and CD were similar to membrane-bound proteins and adaptor proteins, respectively.  (日)    [継承]
キーワード (推奨): 1. (英) Algorithms (日) (読) [継承]
2. (英) Amino Acid Sequence (日) (読) [継承]
3. (英) Carrier Proteins (日) (読) [継承]
4. (英) Computational Biology (日) (読) [継承]
5. (英) Genetic Predisposition to Disease (日) (読) [継承]
6. (英) Genetic Variation (日) (読) [継承]
7. (英) Humans (日) (読) [継承]
8. (英) Intracellular Signaling Peptides and Proteins (日) (読) [継承]
9. (英) Molecular Dynamics Simulation (日) (読) [継承]
10. (英) Protein Domains (日) (読) [継承]
11. (英) Protein Structure, Secondary (日) (読) [継承]
12. (英) Reproducibility of Results (日) (読) [継承]
13. (英) Schizophrenia (日) (読) [継承]
発行所 (推奨): 日本生化学会 [継承]
誌名 (必須): The Journal of Biochemistry ([日本生化学会])
(pISSN: 0021-924X, eISSN: 1756-2651)

ISSN (任意): 1756-2651
ISSN: 0021-924X (pISSN: 0021-924X, eISSN: 1756-2651)
Title: Journal of biochemistry
Title(ISO): J. Biochem.
Supplier: Oxford University Press
Publisher: Oxford University Press
 (NLM Catalog  (医中誌Web  (J-STAGE  (CrossRef (Scopus information is found. [need login])
[継承]
[継承]
(必須): 161 [継承]
(必須): 2 [継承]
(必須): 223 230 [継承]
都市 (任意): オックスフォード (Oxford/[連合王国]) [継承]
年月日 (必須): 西暦 2017年 2月 1日 (平成 29年 2月 1日) [継承]
URL (任意):
DOI (任意): 10.1093/jb/mvw064    (→Scopusで検索) [継承]
PMID (任意): 27815320    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意):
Scopus (任意): 2-s2.0-85015838860 [継承]
機関リポジトリ : 110891 [継承]
評価値 (任意):
被引用数 (任意):
指導教員 (推奨):
備考 (任意): 1.(英) Article.ELocationID: 10.1093/jb/mvw064  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) KeywordList.Keyword: D-amino acid oxidase  (日)    [継承]
4.(英) KeywordList.Keyword: G72  (日)    [継承]
5.(英) KeywordList.Keyword: ab initio method  (日)    [継承]
6.(英) KeywordList.Keyword: schizophrenia  (日)    [継承]
7.(英) KeywordList.Keyword: structure prediction  (日)    [継承]

標準的な表示

和文冊子 ● Yusuke Kato and Kiyoshi Fukui : Structure models of G72, the product of a susceptibility gene to schizophrenia, The Journal of Biochemistry, Vol.161, No.2, 223-230, 2017.
欧文冊子 ● Yusuke Kato and Kiyoshi Fukui : Structure models of G72, the product of a susceptibility gene to schizophrenia, The Journal of Biochemistry, Vol.161, No.2, 223-230, 2017.

関連情報

Number of session users = 2, LA = 0.93, Max(EID) = 371579, Max(EOID) = 992465.