『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
ID: Pass:

登録内容 (EID=321536)

EID=321536EID:321536, Map:0, LastModified:2017年8月27日(日) 19:59:52, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[山本 朗仁], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1.山本 朗仁 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.組織再生制御学])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2. (英) Nagano Takashi (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
3. (英) Takehara Shoko (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
4.日比 正彦
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
5. (英) Aizawa Shinichi (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Shisa promotes head formation through the inhibition of receptor protein maturation for the caudalizing factors, Wnt and FGF.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Head formation requires simultaneous inhibition of multiple caudalizing signals during early vertebrate embryogenesis. We identified a novel antagonist against Wnt and FGF signaling for head formation, Shisa, which functions cell autonomously in the endoplasmic reticulum (ER). Shisa is specifically expressed in the prospective head ectoderm and the Spemann organizer of Xenopus gastrulae. Overexpression of Shisa inhibited both Wnt and FGF signaling in Xenopus embryos and in a cell line. Loss of Shisa function sensitized the neuroectoderm to Wnt signaling and suppressed head formation during gastrulation. Shisa physically interacted with immature forms of the Wnt receptor Frizzled and the FGF receptor within the ER and inhibited their posttranslational maturation and trafficking to the cell surface. Taken together, these findings indicate that Shisa is a novel molecule that controls head formation by regulating the establishment of the receptors for caudalizing factors.  (日)    [継承]
キーワード (推奨): 1. (英) Amino Acid Sequence (日) (読) [継承]
2. (英) Animals (日) (読) [継承]
3. (英) Cells, Cultured (日) (読) [継承]
4. (英) Ectoderm (日) (読) [継承]
5. (英) Embryo, Nonmammalian (日) (読) [継承]
6.小胞体 (endoplasmic reticulum) [継承]
7. (英) Gastrula (日) (読) [継承]
8. (英) Head (日) (読) [継承]
9. (英) Humans (日) (読) [継承]
10. (英) Intercellular Signaling Peptides and Proteins (日) (読) [継承]
11. (英) Low Density Lipoprotein Receptor-Related Protein-6 (日) (読) [継承]
12. (英) Membrane Proteins (日) (読) [継承]
13. (英) Molecular Sequence Data (日) (読) [継承]
14. (英) Organizers, Embryonic (日) (読) [継承]
15. (英) Receptors, Fibroblast Growth Factor (日) (読) [継承]
16. (英) Receptors, LDL (日) (読) [継承]
17. (英) Signal Transduction (日) (読) [継承]
18. (英) Wnt Proteins (日) (読) [継承]
19.アフリカツメガエル (Xenopus laevis) [継承]
20. (英) Xenopus Proteins (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Cell (Cell Press)
(pISSN: 0092-8674, eISSN: 1097-4172)

ISSN (任意): 0092-8674
ISSN: 0092-8674 (pISSN: 0092-8674, eISSN: 1097-4172)
Title: Cell
Title(ISO): Cell
Publisher: Cell Press
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
[継承]
[継承]
(必須): 120 [継承]
(必須): 2 [継承]
(必須): 223 235 [継承]
都市 (任意):
年月日 (必須): 西暦 2005年 1月 28日 (平成 17年 1月 28日) [継承]
URL (任意):
DOI (任意): 10.1016/j.cell.2004.11.051    (→Scopusで検索) [継承]
PMID (任意): 15680328    (→Scopusで検索) [継承]
CRID (任意):
WOS (任意):
Scopus (任意):
評価値 (任意):
被引用数 (任意):
指導教員 (推奨):
備考 (任意): 1.(英) PublicationType: Journal Article  (日)    [継承]
2.(英) PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Akihito Yamamoto, Takashi Nagano, Shoko Takehara, Masahiko Hibi and Shinichi Aizawa : Shisa promotes head formation through the inhibition of receptor protein maturation for the caudalizing factors, Wnt and FGF., Cell, Vol.120, No.2, 223-235, 2005.
欧文冊子 ● Akihito Yamamoto, Takashi Nagano, Shoko Takehara, Masahiko Hibi and Shinichi Aizawa : Shisa promotes head formation through the inhibition of receptor protein maturation for the caudalizing factors, Wnt and FGF., Cell, Vol.120, No.2, 223-235, 2005.

関連情報

Number of session users = 1, LA = 0.92, Max(EID) = 386214, Max(EOID) = 1046649.