| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Fujio Masahito (日) (読)
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| 2. | 山本 朗仁 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.組織再生制御学])
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| 3. | (英) Ando Yuji (日) (読)
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| 4. | (英) Shohara Ryutaro (日) (読)
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| 5. | (英) Kinoshita Kazuhiko (日) (読)
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| 6. | (英) Kaneko Tadashi (日) (読)
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| 7. | (英) Hibi Hideharu (日) (読)
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| 8. | (英) Ueda Minoru (日) (読)
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| ○題名 (必須): | □ | (英) Stromal cell-derived factor-1 enhances distraction osteogenesis-mediated skeletal tissue regeneration through the recruitment of endothelial precursors. (日)
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| ○要約 (任意): | □ | (英) Distraction osteogenesis (DO) is a unique therapy that induces skeletal tissue regeneration without stem/progenitor cell transplantation. Although the self-regeneration property of DO provides many clinical benefits, the long treatment period required is a major drawback. A high-speed DO mouse model (H-DO), in which the distraction was done two times faster than in control DO (C-DO) mice, failed to generate new bone callus in the DO gap. We found that this was caused by the unsuccessful recruitment of bone marrow endothelial cells (BM-ECs)/endothelial progenitor cells (EPCs) into the gap. We then tested the ability of a local application of stromal cell-derived factor-1 (SDF-1), a major chemo-attractant for BM-ECs/EPCs, to accelerate the bone regeneration in H-DO. Our data showed that, in H-DO, SDF-1 induced callus formation in the gap through the recruitment of BM-ECs/EPCs, the maturation of neo-blood vessels, and increased blood flow. These results indicate that the active recruitment of endogenous BM-ECs/EPCs may provide a substantial clinical benefit for shortening the treatment period of DO. (日)
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| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
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| 2. | (英) Blood Vessels (日) (読)
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| 3. | (英) Bone Marrow Cells (日) (読)
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| 4. | (英) Bone Regeneration (日) (読)
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| 5. | (英) Bone and Bones (日) (読)
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| 6. | (英) Bony Callus (日) (読)
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| 7. | (英) Chemokine CXCL12 (日) (読)
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| 8. | (英) Endothelial Cells (日) (読)
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| 9. | (英) Female (日) (読)
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| 10. | (英) Humans (日) (読)
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| 11. | 虚血 (ischemia)
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| 12. | (英) Mice (日) (読)
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| 13. | (英) Mice, Inbred ICR (日) (読)
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| 14. | (英) Models, Animal (日) (読)
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| 15. | (英) Neovascularization, Physiologic (日) (読)
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| 16. | (英) Osteogenesis, Distraction (日) (読)
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| 17. | (英) Receptors, CXCR (日) (読)
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| 18. | (英) Receptors, CXCR4 (日) (読)
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| 19. | (英) Stem Cells (日) (読)
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| 20. | (英) Wound Healing (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Bone (International Bone and Mineral Society)
(pISSN: 8756-3282, eISSN: 1873-2763)
| ○ISSN (任意): | □ | 1873-2763
ISSN: 8756-3282
(pISSN: 8756-3282, eISSN: 1873-2763) Title: BoneTitle(ISO): BonePublisher: Elsevier BV (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 49
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| ○号 (必須): | □ | 4
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| ○頁 (必須): | □ | 693 700
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2011年 6月 29日 (平成 23年 6月 29日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1016/j.bone.2011.06.024 (→Scopusで検索)
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| ○PMID (任意): | □ | 21741502 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) PublicationType: Journal Article (日)
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| 2. | (英) PublicationType: Research Support, Non-U.S. Gov't (日)
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