『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=321518EID:321518, Map:0, LastModified:2020年9月17日(木) 16:48:26, Operator:[三木 ちひろ], Avail:TRUE, Censor:0, Owner:[山本 朗仁], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Matsubara Kohki (日) (読)
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学籍番号 (推奨):
[継承]
2. (英) Matsushita Yoshihiro (日) (読)
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[継承]
3. (英) Sakai Kiyoshi (日) (読)
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[継承]
4.加納 史也 ([徳島大学.大学院医歯薬学研究部.歯学域.先端歯学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.組織再生制御学])
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学籍番号 (推奨):
[継承]
5. (英) Kondo Megumi (日) (読)
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[継承]
6. (英) Noda Mariko (日) (読)
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[継承]
7.橋本 登 ([徳島大学.大学院医歯薬学研究部.歯学域.先端歯学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.組織再生制御学])
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[継承]
8. (英) Imagama Shiro (日) (読)
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[継承]
9. (英) Ishiguro Naoki (日) (読)
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[継承]
10. (英) Suzumura Akio (日) (読)
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[継承]
11. (英) Ueda Minoru (日) (読)
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[継承]
12. (英) Furukawa Koichi (日) (読)
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[継承]
13.山本 朗仁 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.組織再生制御学])
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学籍番号 (推奨):
[継承]
題名 (必須): (英) Secreted ectodomain of sialic acid-binding Ig-like lectin-9 and monocyte chemoattractant protein-1 promote recovery after rat spinal cord injury by altering macrophage polarity.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Engrafted mesenchymal stem cells from human deciduous dental pulp (SHEDs) support recovery from neural insults via paracrine mechanisms that are poorly understood. Here we show that the conditioned serum-free medium (CM) from SHEDs, administered intrathecally into rat injured spinal cord during the acute postinjury period, caused remarkable functional recovery. The ability of SHED-CM to induce recovery was associated with an immunoregulatory activity that induced anti-inflammatory M2-like macrophages. Secretome analysis of the SHED-CM revealed a previously unrecognized set of inducers for anti-inflammatory M2-like macrophages: monocyte chemoattractant protein-1 (MCP-1) and the secreted ectodomain of sialic acid-binding Ig-like lectin-9 (ED-Siglec-9). Depleting MCP-1 and ED-Siglec-9 from the SHED-CM prominently reduced its ability to induce M2-like macrophages and to promote functional recovery after spinal cord injury (SCI). The combination of MCP-1 and ED-Siglec-9 synergistically promoted the M2-like differentiation of bone marrow-derived macrophages in vitro, and this effect was abolished by a selective antagonist for CC chemokine receptor 2 (CCR2) or by the genetic knock-out of CCR2. Furthermore, MCP-1 and ED-Siglec-9 administration into the injured spinal cord induced M2-like macrophages and led to a marked recovery of hindlimb locomotor function after SCI. The inhibition of this M2 induction through the inactivation of CCR2 function abolished the therapeutic effects of both SHED-CM and MCP-1/ED-Siglec-9. Macrophages activated by MCP-1 and ED-Siglec-9 extended neurite and suppressed apoptosis of primary cerebellar granule neurons against the neurotoxic effects of chondroitin sulfate proteoglycans. Our data suggest that the unique combination of MCP-1 and ED-Siglec-9 repairs the SCI through anti-inflammatory M2-like macrophage induction.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Antigens, CD (日) (読) [継承]
3.血液脳関門 (blood-brain barrier) [継承]
4. (英) Brain Injuries (日) (読) [継承]
5. (英) Cell Polarity (日) (読) [継承]
6.小脳 (cerebellum) [継承]
7. (英) Chemokine CCL2 (日) (読) [継承]
8. (英) Child (日) (読) [継承]
9. (英) Culture Media, Conditioned (日) (読) [継承]
10. (英) Cytokines (日) (読) [継承]
11. (英) Dental Pulp (日) (読) [継承]
12. (英) Humans (日) (読) [継承]
13. (英) Macrophages (日) (読) [継承]
14. (英) Mice (日) (読) [継承]
15. (英) Mice, Inbred C57BL (日) (読) [継承]
16. (英) Rats (日) (読) [継承]
17. (英) Rats, Sprague-Dawley (日) (読) [継承]
18. (英) Receptors, CCR2 (日) (読) [継承]
19. (英) Sialic Acid Binding Immunoglobulin-like Lectins (日) (読) [継承]
20. (英) Spinal Cord Injuries (日) (読) [継承]
21. (英) Tooth, Deciduous (日) (読) [継承]
発行所 (推奨):
誌名 (必須): The Journal of Neuroscience (Society for Neuroscience)
(pISSN: 0270-6474, eISSN: 1529-2401)

ISSN (任意): 1529-2401
ISSN: 0270-6474 (pISSN: 0270-6474, eISSN: 1529-2401)
Title: The Journal of neuroscience : the official journal of the Society for Neuroscience
Title(ISO): J Neurosci
Publisher: Society for Neuroscience
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 35 [継承]
(必須): 6 [継承]
(必須): 2452 2464 [継承]
都市 (任意):
年月日 (必須): 西暦 2015年 2月 11日 (平成 27年 2月 11日) [継承]
URL (任意):
DOI (任意): 10.1523/JNEUROSCI.4088-14.2015    (→Scopusで検索) [継承]
PMID (任意): 25673840    (→Scopusで検索) [継承]
CRID (任意):
WOS (任意):
Scopus (任意): 2-s2.0-84922553212 [継承]
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備考 (任意): 1.(英) PublicationType: Journal Article  (日)    [継承]
2.(英) PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Kohki Matsubara, Yoshihiro Matsushita, Kiyoshi Sakai, Fumiya Kano, Megumi Kondo, Mariko Noda, Noboru Hashimoto, Shiro Imagama, Naoki Ishiguro, Akio Suzumura, Minoru Ueda, Koichi Furukawa and Akihito Yamamoto : Secreted ectodomain of sialic acid-binding Ig-like lectin-9 and monocyte chemoattractant protein-1 promote recovery after rat spinal cord injury by altering macrophage polarity., The Journal of Neuroscience, Vol.35, No.6, 2452-2464, 2015.
欧文冊子 ● Kohki Matsubara, Yoshihiro Matsushita, Kiyoshi Sakai, Fumiya Kano, Megumi Kondo, Mariko Noda, Noboru Hashimoto, Shiro Imagama, Naoki Ishiguro, Akio Suzumura, Minoru Ueda, Koichi Furukawa and Akihito Yamamoto : Secreted ectodomain of sialic acid-binding Ig-like lectin-9 and monocyte chemoattractant protein-1 promote recovery after rat spinal cord injury by altering macrophage polarity., The Journal of Neuroscience, Vol.35, No.6, 2452-2464, 2015.

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