『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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カテゴリ (推奨):
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組織 (推奨):
著者 (必須): 1. (英) Shimojima Chiaki (日) (読)
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[継承]
2. (英) Takeuchi Hideyuki (日) (読)
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[継承]
3. (英) Jin Shijie (日) (読)
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4. (英) Parajuli Bijay (日) (読)
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5. (英) Hattori Hisashi (日) (読)
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6. (英) Suzumura Akio (日) (読)
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7. (英) Hibi Hideharu (日) (読)
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8. (英) Ueda Minoru (日) (読)
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9.山本 朗仁 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.組織再生制御学])
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[継承]
題名 (必須): (英) Conditioned Medium from the Stem Cells of Human Exfoliated Deciduous Teeth Ameliorates Experimental Autoimmune Encephalomyelitis.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Multiple sclerosis (MS) is a major neuroinflammatory demyelinating disease of the CNS. Current MS treatments, including immunomodulators and immunosuppressants, do not result in complete remission. Stem cells from human exfoliated deciduous teeth (SHEDs) are mesenchymal stem cells derived from dental pulp. Both SHED and SHED-conditioned medium (SHED-CM) exhibit immunomodulatory and regenerative activities and have the potential to treat various diseases. In this study, we investigated the efficacy of SHED-CM in treating experimental autoimmune encephalomyelitis (EAE), a mouse model of MS. EAE mice treated with a single injection of SHED-CM exhibited significantly improved disease scores, reduced demyelination and axonal injury, and reduced inflammatory cell infiltration and proinflammatory cytokine expression in the spinal cord, which was associated with a shift in the microglia/macrophage phenotype from M1 to M2. SHED-CM also inhibited the proliferation of myelin oligodendrocyte glycoprotein-specific CD4(+) T cells, as well as their production of proinflammatory cytokines in vitro. Treatment of EAE mice with the secreted ectodomain of sialic acid-binding Ig-like lectin-9, a major component of SHED-CM, recapitulated the effects of SHED-CM treatment. Our data suggest that SHED-CM and secreted ectodomain of sialic acid-binding Ig-like lectin-9 may be novel therapeutic treatments for autoimmune diseases, such as MS.  (日)    [継承]
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誌名 (必須): The Journal of Immunology ([The American Association of Immunologists])
(pISSN: 0022-1767, eISSN: 1550-6606)

ISSN (任意): 1550-6606
ISSN: 0022-1767 (pISSN: 0022-1767, eISSN: 1550-6606)
Title: Journal of immunology (Baltimore, Md. : 1950)
Title(ISO): J Immunol
Publisher: American Association of Immunologists
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 196 [継承]
(必須): 10 [継承]
(必須): 4164 4171 [継承]
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年月日 (必須): 西暦 2016年 4月 6日 (平成 28年 4月 6日) [継承]
URL (任意):
DOI (任意): 10.4049/jimmunol.1501457    (→Scopusで検索) [継承]
PMID (任意): 27053763    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Chiaki Shimojima, Hideyuki Takeuchi, Shijie Jin, Bijay Parajuli, Hisashi Hattori, Akio Suzumura, Hideharu Hibi, Minoru Ueda and Akihito Yamamoto : Conditioned Medium from the Stem Cells of Human Exfoliated Deciduous Teeth Ameliorates Experimental Autoimmune Encephalomyelitis., The Journal of Immunology, Vol.196, No.10, 4164-4171, 2016.
欧文冊子 ● Chiaki Shimojima, Hideyuki Takeuchi, Shijie Jin, Bijay Parajuli, Hisashi Hattori, Akio Suzumura, Hideharu Hibi, Minoru Ueda and Akihito Yamamoto : Conditioned Medium from the Stem Cells of Human Exfoliated Deciduous Teeth Ameliorates Experimental Autoimmune Encephalomyelitis., The Journal of Immunology, Vol.196, No.10, 4164-4171, 2016.

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