| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): | □ | Peer Review
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| ○カテゴリ (推奨): | □ | 研究
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| ○共著種別 (推奨): | □ | 国内共著 (徳島大学内研究者と国内(学外)研究者との共同研究 (国外研究者を含まない))
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| ○学究種別 (推奨): | □ | 博士課程学生による研究報告
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| ○組織 (推奨): | 1. | 徳島大学.口腔科学研究科.口腔科学専攻.口腔健康科学講座.口腔顎顔面形態学 (2004年4月1日〜)
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| ○著者 (必須): | 1. | 三野 彰子 ([徳島大学.口腔科学研究科.口腔科学専攻.口腔健康科学講座.口腔顎顔面矯正学])
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| 2. | 井澤 俊
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 3. | 篠原 丈裕 ([徳島大学.口腔科学研究科.口腔科学専攻.口腔健康科学講座.口腔顎顔面矯正学])
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| 4. | 森 浩喜
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 5. | 泰江 章博
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 6. | 冨田 修平
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 7. | 田中 栄二 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.口腔顎顔面矯正学])
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| ○題名 (必須): | □ | (英) Roles of hypoxia inducible factor-1α in the temporomandibular joint. (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Temporomandibular joint osteoarthritis (TMJ-OA) is a degenerative disease characterized by permanent cartilage loss. Articular cartilage is maintained in a low-oxygen environment. The chondrocyte response to hypoxic conditions involves expression of hypoxia inducible factor 1α (HIF-1α), which induces chondrocytes to increase expression of vascular endothelial growth factor (VEGF). Here, we investigated the role of HIF-1α in mechanical load effects on condylar cartilage and subchondral bone in heterozygous HIF-1α-deficient mice (HIF-1α(+/-)). Mechanical stress was applied to the TMJ of C57BL/6NCr wild-type (WT) and HIF-1α(+/-) mice with a sliding plate for 10 days. Histological analysis was performed by HE staining, Safranin-O/Fast green staining, and immunostaining specific for articular cartilage homeostasis. HIF-1α(+/-) mice had thinner cartilage and smaller areas of proteoglycan than WT controls, without and with mechanical stress. Mechanical stress resulted in prominent degenerative changes with increased expression of HIF-1α, VEGF, and the apoptosis factor cleaved Caspase-3 in condylar cartilage. Our results indicate that HIF-1α may be important for articular cartilage homeostasis and protective against articular cartilage degradation in the TMJ under mechanical stress condition, therefore HIF-1α could be an important new therapeutic target in TMJ-OA. (日)
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| ○キーワード (推奨): |
| ○発行所 (推奨): | □ | Elsevier Science
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| ○誌名 (必須): | □ | Archives of Oral Biology ([Elsevier])
(pISSN: 0003-9969, eISSN: 1879-1506)
| ○ISSN (任意): | □ | 1879-1506
ISSN: 0003-9969
(pISSN: 0003-9969, eISSN: 1879-1506) Title: Archives of oral biologyTitle(ISO): Arch Oral BiolPublisher: Elsevier Ltd (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 73
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| ○号 (必須): | □ |
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| ○頁 (必須): | □ | 274 281
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2017年 1月 初日 (平成 29年 1月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1016/j.archoralbio.2016.10.028 (→Scopusで検索)
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| ○PMID (任意): | □ | 27816790 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.ELocationID: S0003-9969(16)30317-X (日)
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| 2. | (英) Article.ELocationID: 10.1016/j.archoralbio.2016.10.028 (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 4. | (英) KeywordList.Keyword: Articular cartilage degradation (日)
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| 5. | (英) KeywordList.Keyword: Chondrocyte apoptosis (日)
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| 6. | (英) KeywordList.Keyword: Hypoxia inducible factor-1α (日)
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| 7. | (英) KeywordList.Keyword: Temporomandibular joint osteoarthritis (TMJ-OA) (日)
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