『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=320452EID:320452, Map:0, LastModified:2017年8月29日(火) 14:54:42, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[岡村 裕彦], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨): 国際共著 (徳島大学内研究者と国外研究機関所属研究者との共同研究) [継承]
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著者 (必須): 1.楊 諦
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2.岡村 裕彦
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3.森本 景之
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4.寺町 順平
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5.羽地 達次
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題名 (必須): (英) Protein phosphatase 2A Cα regulates proliferation, migration, and metastasis of osteosarcoma cells.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Osteosarcoma is the most frequent primary bone tumor. Serine/threonine protein phosphatase 2A (PP2A) participates in regulating many important physiological processes, such as cell cycle, growth, apoptosis, and signal transduction. In this study, we examined the expression and function of PP2A Cα in osteosarcoma cells. PP2A Cα expression was expected to be higher in malignant osteosarcoma tissues. PP2A Cα expression level and PP2A activity was higher in malignant osteosarcoma LM8 cells compared with that in primary osteoblasts and in the osteoblast-like cell line MC3T3-E1. Okadaic acid, an inhibitor of PP2A, reduced cell viability and induced apoptosis in LM8 cells. PP2A Cα-knockdown LM8 cells (shPP2A) exhibited less striking filopodial and lamellipodial structures than that in original LM8 cells. Focal adhesion kinase phosphorylation and NF-κB activity decreased in shPP2A-treated cells. Sensitivity to serum deprivation-induced apoptosis increased in shPP2A-treated cells, accompanied by a lower expression level of anti-apoptotic BCL-2 in these cells. Reduction of PP2A Cα resulted in a decrease in the migration ability of LM8 cells in vitro. Reduction in PP2A Cα levels in vivo suppressed proliferation and metastasis in LM8 cells. PP2A Cα expression was also higher in human osteosarcoma MG63 and SaOS-2 cells than that in primary osteoblasts and MC3T3-E1 cells, and reduction in PP2A Cα levels suppressed the cell proliferation rate and migration ability of MG63 cells. These results indicate that PP2A Cα has a critical role in the proliferation and metastasis of osteosarcoma cells; therefore, its inhibition could potentially suppress the malignancy of osteosarcoma cells.  (日)    [継承]
キーワード (推奨): 1.蛋白質脱リン酸化 (protein dephosphorylation) [継承]
2.骨芽細胞 (osteoblast) [継承]
発行所 (推奨):
誌名 (必須): Laboratory Investigation; a Journal of Technical Methods and Pathology (United States and Canadian Academy of Pathology)
(pISSN: 0023-6837, eISSN: 1530-0307)

ISSN (任意): 1530-0307
ISSN: 0023-6837 (pISSN: 0023-6837, eISSN: 1530-0307)
Title: Laboratory investigation; a journal of technical methods and pathology
Title(ISO): Lab Invest
Publisher: Springer Science+Business Media
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(必須): 1050 1062 [継承]
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年月日 (必須): 西暦 2016年 10月 初日 (平成 28年 10月 初日) [継承]
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DOI (任意): 10.1038/labinvest.2016.82    (→Scopusで検索) [継承]
PMID (任意): 27617401    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.ELocationID: 10.1038/labinvest.2016.82  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Di Yang, Hirohiko Okamura, Hiroyuki Morimoto, Jumpei Teramachi and Tatsuji Haneji : Protein phosphatase 2A Cα regulates proliferation, migration, and metastasis of osteosarcoma cells., Laboratory Investigation; a Journal of Technical Methods and Pathology, Vol.96, No.10, 1050-1062, 2016.
欧文冊子 ● Di Yang, Hirohiko Okamura, Hiroyuki Morimoto, Jumpei Teramachi and Tatsuji Haneji : Protein phosphatase 2A Cα regulates proliferation, migration, and metastasis of osteosarcoma cells., Laboratory Investigation; a Journal of Technical Methods and Pathology, Vol.96, No.10, 1050-1062, 2016.

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