| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): | □ | Peer Review
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| ○カテゴリ (推奨): | □ | 研究
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| ○共著種別 (推奨): | □ | 国際共著 (徳島大学内研究者と国外研究機関所属研究者との共同研究)
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| ○学究種別 (推奨): | □ | 博士課程学生による研究報告
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| ○組織 (推奨): | 1. | 徳島大学.口腔科学研究科.口腔科学専攻.口腔健康科学講座.口腔顎顔面形態学 (2004年4月1日〜)
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| ○著者 (必須): | 1. | 篠原 丈裕 ([徳島大学.口腔科学研究科.口腔科学専攻.口腔健康科学講座.口腔顎顔面矯正学])
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| 2. | 井澤 俊
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| 3. | 三野 彰子 ([徳島大学.口腔科学研究科.口腔科学専攻.口腔健康科学講座.口腔顎顔面矯正学])
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| 4. | 森 浩喜
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| 5. | 岩浅 亮彦
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| 6. | 犬伏 俊博 ([広島大学])
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| 7. | (英) Yamaguchi Yu (日) (読)
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| 8. | 田中 栄二 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.口腔顎顔面矯正学])
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| ○題名 (必須): | □ | (英) Hyaluronan metabolism in overloaded temporomandibular joint (日)
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| ○要約 (任意): | □ | (英) This study aimed to examine hyaluronan (HA) metabolism in relation to the onset and progression of temporomandibular joint osteoarthritis (TMJ-OA) induced by mechanical overloading. Two-month-old and 6-month-old C57BL/6N mice were divided into experimental and untreated control groups (n = 5/group). A sliding plate was attached to the maxillary incisors of the experimental mice for 10 days to overload the condylar cartilage in TMJ. In experimental group, profound cartilage degradation was detected in haematoxylin-eosin, Safranin-O-Fast Green-stained sections. It was also shown that the cartilage degradation was greater in older mice in both the control and the experimental groups. The number of HABP-positive cells was decreased by mechanical overloading and with age. The reduction of HA expression was correlated with the progression of cartilage degradation induced by mechanical overloading. The absolute quantification of the mRNA expression related to HA synthesis and HA degradation was also performed in each group. The mRNA expression levels of HA synthase (HAS) 2 and 3 were lower in the experimental group compared with the control group in the younger mice. In contrast, the mRNA expression levels of the HA degradation gene, HYAL2 and KIAA1199, were higher in the experimental group compared with the control group in the older mice. Thus, mechanical overload differently affected the balance of HA degradation and HA synthesis in the older and younger mice, respectively. In conclusion, mechanical overloading affects HA metabolism and it might initiate or amplify the condylar cartilage degradation. (日)
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| ○キーワード (推奨): |
| ○発行所 (推奨): | □ | Blackwell Publishing Ltd
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| ○誌名 (必須): | □ | Journal of Oral Rehabilitation ([Blackwell Publishing Ltd])
(pISSN: 0305-182X, eISSN: 1365-2842)
| ○ISSN (任意): | □ | 1365-2842
ISSN: 0305-182X
(pISSN: 0305-182X, eISSN: 1365-2842) Title: Journal of oral rehabilitationTitle(ISO): J Oral RehabilPublisher: Blackwell (NLM Catalog)
(Wiley)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 43
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| ○号 (必須): | □ | 12
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| ○頁 (必須): | □ | 921 928
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2016年 12月 初日 (平成 28年 12月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1111/joor.12443 (→Scopusで検索)
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| ○PMID (任意): | □ | 27627706 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS (任意): |
| ○Scopus (任意): | □ | 2-s2.0-84994718053
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| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1111/joor.12443 (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) KeywordList.Keyword: hyaluronan (日)
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| 4. | (英) KeywordList.Keyword: osteoarthritis (日)
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| 5. | (英) KeywordList.Keyword: temporomandibular joint (日)
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