『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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登録内容 (EID=319967)

EID=319967EID:319967, Map:0, LastModified:2016年9月1日(木) 14:54:59, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[土井 俊夫], Read:継承, Write:継承, Delete:継承.
種別 (必須):
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Tamaki Masanori (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
2. (英) Hagiwara Aika (日) (読)
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学籍番号 (推奨):
[継承]
3. (英) Miyashita Kazutoshi (日) (読)
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学籍番号 (推奨):
[継承]
4. (英) Wakino Shu (日) (読)
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学籍番号 (推奨):
[継承]
5. (英) Inoue Hiroyuki (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
6. (英) Fujii Kentaro (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
7. (英) Fujii Chikako (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
8. (英) Sato Masaaki (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
9. (英) Mitsuishi Masanori (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
10. (英) Muraki Ayako (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
11. (英) Hayashi Koichi (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
12.土井 俊夫
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学籍番号 (推奨):
[継承]
13. (英) Itoh Hiroshi (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Improvement of Physical Decline Through Combined Effects of Muscle Enhancement and Mitochondrial Activation by a Gastric Hormone Ghrelin in Male 5/6Nx CKD Model Mice.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Because a physical decline correlates with an increased risk of a wide range of disease and morbidity, an improvement of physical performance is expected to bring significant clinical benefits. The primary cause of physical decline in 5/6 nephrectomized (5/6Nx) chronic kidney disease model mice has been regarded as a decrease in muscle mass; however, our recent study showed that a decrease in muscle mitochondria plays a critical role. In the present study, we examined the effects of a gastric hormone ghrelin, which has been reported to promote muscle mitochondrial oxidation, on the physical decline in the chronic kidney disease model mice, focusing on the epigenetic modulations of a mitochondrial activator gene, peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α). Ghrelin treatment improved a decline in exercise endurance of 5/6Nx mice, associated with an increase in both of the muscle mass and mitochondrial amount. The expression level of PGC-1α was decreased in the skeletal muscle of 5/6Nx mice, which was associated with an increase in the methylation ratio of the cytosine residue at 260 base pairs upstream of the initiation point. Conversely, ghrelin treatment de-methylated the cytosine residue and increased the expression of PGC-1α. A representative muscle anabolic factor, IGF-1, did not affect the expression of PGC-1α and muscle mitochondrial amount, although it increased muscle mass. As a result, IGF-1 treatment in 5/6Nx mice did not increase the decreased exercise endurance as effectively as ghrelin treatment did. These findings indicate an advantage of ghrelin treatment for a recovery of physical decline.  (日)    [継承]
キーワード (推奨): 1. (英) AMP-Activated Protein Kinases (日) (読) [継承]
2. (英) Animals (日) (読) [継承]
3. (英) Blotting, Western (日) (読) [継承]
4. (英) Cell Line (日) (読) [継承]
5. (英) DNA Methylation (日) (読) [継承]
6. (英) Disease Models, Animal (日) (読) [継承]
7. (英) Electron Transport Complex IV (日) (読) [継承]
8. (英) Gene Expression (日) (読) [継承]
9. (英) Ghrelin (日) (読) [継承]
10. (英) Male (日) (読) [継承]
11. (英) Mice, Inbred C57BL (日) (読) [継承]
12. (英) Mitochondria, Muscle (日) (読) [継承]
13. (英) Motor Activity (日) (読) [継承]
14. (英) Muscle Weakness (日) (読) [継承]
15. (英) Muscle, Skeletal (日) (読) [継承]
16. (英) Myoblasts (日) (読) [継承]
17. (英) Nephrectomy (日) (読) [継承]
18. (英) RNA Interference (日) (読) [継承]
19. (英) Receptors, Ghrelin (日) (読) [継承]
20. (英) Renal Insufficiency, Chronic (日) (読) [継承]
21. (英) Reverse Transcriptase Polymerase Chain Reaction (日) (読) [継承]
22. (英) Transcription Factors (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Endocrinology ([The Endocrine Society])
(pISSN: 0013-7227, eISSN: 1945-7170)

ISSN (任意): 1945-7170
ISSN: 0013-7227 (pISSN: 0013-7227, eISSN: 1945-7170)
Title: Endocrinology
Title(ISO): Endocrinology
Publisher: Endocrine Society
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
[継承]
[継承]
(必須): 156 [継承]
(必須): 10 [継承]
(必須): 3638 3648 [継承]
都市 (任意):
年月日 (必須): 西暦 2015年 8月 4日 (平成 27年 8月 4日) [継承]
URL (任意):
DOI (任意): 10.1210/en.2015-1353    (→Scopusで検索) [継承]
PMID (任意): 26241123    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.ELocationID: 10.1210/en.2015-1353  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● (種別) : Masanori Tamaki, Aika Hagiwara, Kazutoshi Miyashita, Shu Wakino, Hiroyuki Inoue, Kentaro Fujii, Chikako Fujii, Masaaki Sato, Masanori Mitsuishi, Ayako Muraki, Koichi Hayashi, Toshio Doi and Hiroshi Itoh : Improvement of Physical Decline Through Combined Effects of Muscle Enhancement and Mitochondrial Activation by a Gastric Hormone Ghrelin in Male 5/6Nx CKD Model Mice., Endocrinology, Vol.156, No.10, 3638-3648, (発行所), (都市), Aug. 2015.
欧文冊子 ● (種別) : Masanori Tamaki, Aika Hagiwara, Kazutoshi Miyashita, Shu Wakino, Hiroyuki Inoue, Kentaro Fujii, Chikako Fujii, Masaaki Sato, Masanori Mitsuishi, Ayako Muraki, Koichi Hayashi, Toshio Doi and Hiroshi Itoh : Improvement of Physical Decline Through Combined Effects of Muscle Enhancement and Mitochondrial Activation by a Gastric Hormone Ghrelin in Male 5/6Nx CKD Model Mice., Endocrinology, Vol.156, No.10, 3638-3648, (発行所), (都市), Aug. 2015.

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