『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
ID: Pass:

登録内容 (EID=319370)

EID=319370EID:319370, Map:0, LastModified:2018年5月4日(金) 20:00:11, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[向井 理恵], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Kamada Chiemi (日) 鎌田 智英実 (読) かまだ ちえみ
役割 (任意):
貢献度 (任意):
学籍番号 (推奨): **** [ユーザ]
[継承]
2.向井 理恵 ([徳島大学.大学院社会産業理工学研究部.生物資源産業学域.食料科学系.食料科学分野])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
3. (英) Kondo Akari (日) 近藤 あかり (読) こんどう あかり
役割 (任意):
貢献度 (任意):
学籍番号 (推奨): **** [ユーザ]
[継承]
4. (英) Sato Shinya (日) 佐藤 伸哉 (読) さとう しんや
役割 (任意):
貢献度 (任意):
学籍番号 (推奨): **** [ユーザ]
[継承]
5.寺尾 純二
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Effect of quercetin and its metabolite on caveolin-1 expression induced by oxidized LDL and lysophosphatidylcholine in endothelial cells.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Oxidized low-density lipoprotein contributes to atherosclerotic plaque formation, and quercetin is expected to exert anti-atherosclerotic effects. We previously reported accumulation of conjugated quercetin metabolites in the aorta of rabbits fed high-cholesterol diets with quercetin glucosides, resulting in attenuation of lipid peroxidation and inhibition of lipid accumulation. Caveolin-1, a major structural protein of caveolae in vascular endothelial cells, plays a role in atherosclerosis development. Here we investigated effects of oxidized low-density lipoprotein, quercetin and its metabolite, quercetin 3-O--glucuronide, on caveolin-1 expression. Oxidized low-density lipoprotein significantly upregulated caveolin-1 mRNA expression. An oxidized low-density lipoprotein component, lysophosphatidylcholine, also induced expression of both caveolin-1 mRNA and protein. However, lysophosphatidylcholine did not affect the location of caveolin-1 proteins within caveolae structures. Co-treatment with quercetin or quercetin 3-O--glucuronide inhibited lysophosphatidylcholine-induced caveolin-1 expression. Quercetin and quercetin 3-O--glucuronide also suppressed expression of adhesion molecules induced by oxidized low-density lipoprotein and lysophosphatidylcholine. These results strongly suggest lysophosphatidylcholine derived from oxidized low-density lipoprotein contributes to atherosclerotic events by upregulating caveolin-1 expression, resulting in induction of adhesion molecules. Quercetin metabolites are likely to exert an anti-atherosclerotic effect by attenuating caveolin-1 expression in endothelial cells.  (日)    [継承]
キーワード (推奨):
発行所 (推奨):
誌名 (必須): Journal of Clinical Biochemistry and Nutrition (日本酸化ストレス学会)
(pISSN: 0912-0009, eISSN: 1880-5086)

ISSN (任意): 0912-0009
ISSN: 0912-0009 (pISSN: 0912-0009, eISSN: 1880-5086)
Title: Journal of clinical biochemistry and nutrition
Title(ISO): J Clin Biochem Nutr
Supplier: 一般社団法人 日本酸化ストレス学会
Publisher: The Society for Free Radical Research Japan
 (NLM Catalog  (医中誌Web  (J-STAGE  (Scopus  (CrossRef (Scopus information is found. [need login])
[継承]
[継承]
(必須): 58 [継承]
(必須): 3 [継承]
(必須): 193 201 [継承]
都市 (任意):
年月日 (必須): 西暦 2016年 4月 16日 (平成 28年 4月 16日) [継承]
URL (任意):
DOI (任意): 10.3164/jcbn.16-2    (→Scopusで検索) [継承]
PMID (任意): 27257344    (→Scopusで検索) [継承]
CRID (任意):
WOS (任意):
Scopus (任意):
評価値 (任意):
被引用数 (任意):
指導教員 (推奨):
備考 (任意): 1.(英) PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Chiemi Kamada, Rie Mukai, Akari Kondo, Shinya Sato and Junji Terao : Effect of quercetin and its metabolite on caveolin-1 expression induced by oxidized LDL and lysophosphatidylcholine in endothelial cells., Journal of Clinical Biochemistry and Nutrition, Vol.58, No.3, 193-201, 2016.
欧文冊子 ● Chiemi Kamada, Rie Mukai, Akari Kondo, Shinya Sato and Junji Terao : Effect of quercetin and its metabolite on caveolin-1 expression induced by oxidized LDL and lysophosphatidylcholine in endothelial cells., Journal of Clinical Biochemistry and Nutrition, Vol.58, No.3, 193-201, 2016.

関連情報

Number of session users = 0, LA = 0.40, Max(EID) = 408927, Max(EOID) = 1108109.