| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | 箕田 直治
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| 2. | 川人 伸次 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.歯科麻酔科学])
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| 3. | 曽我 朋宏
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| 4. | 高石 和美 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.歯科麻酔科学]/[徳島大学.病院.診療科.歯科口腔外科.歯科麻酔科]/[徳島大学.歯学部.歯学科.口腔疾患系臨床歯学講座.歯科麻酔科学])
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| 5. | 北畑 洋
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| 6. | 松久 宗英 ([徳島大学.先端酵素学研究所.基幹研究部門]/徳島大学病院アンチエイジングセンター センター長(併任)/徳島大学先端酵素学研究所長(併任))
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| 7. | 島田 光生
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| 8. | (英) Hiroyuki Kinoshita (日) (読)
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| 9. | 堤 保夫
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| 10. | 田中 克哉 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.麻酔・疼痛治療医学]/[徳島大学.病院.診療科.脳·神経·精神科])
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| ○題名 (必須): | □ | (英) Strict blood glucose control by an artificial endocrine pancreas during hepatectomy may prevent postoperative acute kidney injury (日)
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| ○要約 (任意): | □ | (英) The aim of the present study was to evaluate the usefulness of a closed-loop system (STG-55; Nikkiso, Tokyo, Japan), a type of artificial endocrine pancreas for the continuous monitoring and control of intraoperative blood glucose, for preventing postoperative acute kidney injury (AKI) in patients undergoing hepatectomy. Thirty-eight patients were enrolled in this study. Glucose concentrations were controlled with either a manual injection of insulin based on a commonly used sliding scale (manual insulin group, n = 19) or the programmed infusion of insulin determined by the control algorithm of the artificial endocrine pancreas (programmed insulin group, n = 19). After the induction of anesthesia, a 20-G intravenous catheter was inserted into the peripheral forearm vein of patients in the programmed insulin group and connected to an artificial endocrine pancreas (STG-55). The target range for glucose concentrations was set to 100-150 mg/dL. The mean serum creatinine concentrations of preoperative, postoperative 24 and 48 h were 0.72, 0.78, and 0.79 mg/dL in the programmed insulin group, and 0.81, 0.95, and 1.03 mg/dL in the manual insulin group, respectively. Elevations in serum creatinine concentrations postoperative 48 h were significantly suppressed in the programmed insulin group. The STG-55 closed-loop system was effective for maintaining strict blood glucose control during hepatectomy with minimal variability in blood glucose concentrations and for suppressing elevations in serum creatinine concentrations. Strict blood glucose control by an artificial endocrine pancreas during hepatectomy may prevent postoperative AKI. (日)
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| ○キーワード (推奨): | 1. | (英) Acute Kidney Injury (日) (読)
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| 2. | (英) Aged (日) (読)
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| 3. | (英) Aged, 80 and over (日) (読)
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| 4. | (英) Blood Glucose (日) (読)
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| 5. | (英) Creatinine (日) (読)
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| 6. | (英) Female (日) (読)
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| 7. | (英) Hepatectomy (日) (読)
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| 8. | (英) Humans (日) (読)
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| 9. | (英) Insulin (日) (読)
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| 10. | (英) Insulin Infusion Systems (日) (読)
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| 11. | (英) Japan (日) (読)
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| 12. | (英) Male (日) (読)
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| 13. | (英) Middle Aged (日) (読)
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| 14. | (英) Pancreas, Artificial (日) (読)
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| 15. | (英) Postoperative Complications (日) (読)
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| 16. | (英) Treatment Outcome (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Journal of Artificial Organs (日本人工臓器学会)
(pISSN: 1434-7229, eISSN: 1619-0904)
| ○ISSN (任意): | □ | 1619-0904
ISSN: 1434-7229
(pISSN: 1434-7229, eISSN: 1619-0904) Title: Journal of artificial organs : the official journal of the Japanese Society for Artificial OrgansTitle(ISO): J Artif OrgansSupplier: Springer Online Journal ArchivePublisher: Springer (NLM Catalog)
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| ○巻 (必須): | □ | 20
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| ○号 (必須): | □ | 1
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| ○頁 (必須): | □ | 76 83
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2017年 3月 末日 (平成 29年 3月 末日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1007/s10047-016-0925-6 (→Scopusで検索)
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| ○PMID (任意): | □ | 27557726 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1007/s10047-016-0925-6 (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) KeywordList.Keyword: Acute kidney injury (日)
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| 4. | (英) KeywordList.Keyword: Artificial endocrine pancreas (日)
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| 5. | (英) KeywordList.Keyword: Continuous blood glucose monitoring (日)
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| 6. | (英) KeywordList.Keyword: Hepatectomy (日)
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| 7. | (英) KeywordList.Keyword: Intensive insulin therapy (日)
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