『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=318919EID:318919, Map:0, LastModified:2017年6月10日(土) 18:36:59, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[有持 秀喜], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨): 国内共著 (徳島大学内研究者と国内(学外)研究者との共同研究 (国外研究者を含まない)) [継承]
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1.森田 恭二
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学籍番号 (推奨):
[継承]
2.後藤田 貴子
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学籍番号 (推奨):
[継承]
3.有持 秀喜 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.生体防御医学])
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[継承]
4. (英) Mi-Sook Lee (日) (読)
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[継承]
5. (英) Song Her (日) (読)
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学籍番号 (推奨):
[継承]
題名 (必須): (英) Histone deacetylase inhibitors promote neurosteroid-mediated cell differentiation and enhance serotonin-stimulated brain-derived neurotrophic factor gene expression in rat C6 glioma cells  (日)    [継承]
副題 (任意):
要約 (任意): (英) Progesterone treatment has previously been reported to promote the differentiation of glial cells probably through the production of 5alpha-reduced neurosteroids, resulting in the enhancement of serotonin-stimulated brain-derived neurotrophic factor (BDNF) gene expression, which is considered to contribute to the survival, regeneration, and plasticity of neuronal cells in the brain and hence has been suggested to improve mood disorders and other symptoms in depressive patients. Based on these previous observations, the effects on glial cells of histone deacetylase (HDAC) inhibitors, which are known as agents promoting cell differentiation, were examined using rat C6 glioma cells as a model for in vitro studies. Consequently, trichostatin A (TSA), sodium butyrate (NaB), and valproic acid (VPA) stimulated glial fibrillary acidic protein (GFAP) gene expression, and their stimulatory effects on GFAP gene expression were inhibited by treatment of these cells with finasteride, an inhibitor of the enzyme producing 5alpha-reduced neurosteroids. In addition, HDAC inhibitors enhanced serotonin-stimulated BDNF gene expression, the enhancement of which could be abolished by the inhibition of 5alpha-reduced neurosteroid production in the glioma cells. These results suggest that HDAC inhibitors may be able to promote the differentiation of rat C6 glioma cells through the production of 5alpha-reduced neurosteroids, resulting in the enhancement of serotonin-stimulated BDNF gene expression as a consequence of promoting their differentiation, indicating the possibility that differentiated glial cells may be implicated in preserving the integrity of neural networks as well as improving the function of neuronal cells in the brain.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Brain-Derived Neurotrophic Factor (日) (読) [継承]
3. (英) Butyrates (日) (読) [継承]
4. (英) Cell Differentiation (日) (読) [継承]
5. (英) Cell Line, Tumor (日) (読) [継承]
6. (英) Dose-Response Relationship, Drug (日) (読) [継承]
7. (英) Enzyme Inhibitors (日) (読) [継承]
8. (英) Finasteride (日) (読) [継承]
9. (英) Gene Expression (日) (読) [継承]
10. (英) Glial Fibrillary Acidic Protein (日) (読) [継承]
11. (英) Histone Deacetylase Inhibitors (日) (読) [継承]
12. (英) Hydroxamic Acids (日) (読) [継承]
13. (英) Neuroglia (日) (読) [継承]
14. (英) RNA, Messenger (日) (読) [継承]
15. (英) Rats (日) (読) [継承]
16. (英) Serotonin (日) (読) [継承]
17. (英) Sodium Compounds (日) (読) [継承]
18. (英) Steroids (日) (読) [継承]
19. (英) Time Factors (日) (読) [継承]
20. (英) Valproic Acid (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Journal of Neuroscience Research (Wiley Interscience)
(pISSN: 0360-4012, eISSN: 1097-4547)

ISSN (任意): 1097-4547
ISSN: 0360-4012 (pISSN: 0360-4012, eISSN: 1097-4547)
Title: Journal of neuroscience research
Title(ISO): J. Neurosci. Res.
Publisher: Wiley
 (NLM Catalog  (Wiley  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 87 [継承]
(必須): 11 [継承]
(必須): 2608 2614 [継承]
都市 (任意):
年月日 (必須): 西暦 2009年 8月 15日 (平成 21年 8月 15日) [継承]
URL (任意):
DOI (任意): 10.1002/jnr.22072    (→Scopusで検索) [継承]
PMID (任意): 19360904    (→Scopusで検索) [継承]
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Scopus (任意): 2-s2.0-70349234526 [継承]
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備考 (任意): 1.(英) Article.ELocationID: 10.1002/jnr.22072  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Kyoji Morita, Takako Gotohda, Hideki Arimochi, Lee Mi-Sook and Her Song : Histone deacetylase inhibitors promote neurosteroid-mediated cell differentiation and enhance serotonin-stimulated brain-derived neurotrophic factor gene expression in rat C6 glioma cells, Journal of Neuroscience Research, Vol.87, No.11, 2608-2614, 2009.
欧文冊子 ● Kyoji Morita, Takako Gotohda, Hideki Arimochi, Lee Mi-Sook and Her Song : Histone deacetylase inhibitors promote neurosteroid-mediated cell differentiation and enhance serotonin-stimulated brain-derived neurotrophic factor gene expression in rat C6 glioma cells, Journal of Neuroscience Research, Vol.87, No.11, 2608-2614, 2009.

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