『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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著者 (必須): 1. (英) Yang G-X (日) (読)
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2. (英) Sun Y (日) (読)
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3.常山 幸一 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.疾患病理学])
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4. (英) Zhang W (日) (読)
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5. (英) Leung S. C. P (日) (読)
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6. (英) He X-S (日) (読)
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7. (英) Ansari A. A (日) (読)
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8. (英) Bowlus C (日) (読)
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9. (英) Ridgway M. W (日) (読)
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10. (英) Gershwin E. M (日) (読)
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題名 (必須): (英) Endogenous interleukin-22 protects against inflammatory bowel disease but not autoimmune cholangitis in dominant negative form of transforming growth factor beta receptor type II mice.  (日)    [継承]
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要約 (任意): (英) During chronic inflammation, interleukin (IL)-22 expression is up-regulated in both CD4 and CD8 T cells, exerting a protective role in infections. However, in autoimmunity, IL-22 appears to have either a protective or a pathogenic role in a variety of murine models of autoimmunity and, by extrapolation, in humans. It is not clear whether IL-22 itself mediates inflammation or is a by-product of inflammation. We have taken advantage of the dominant negative form of transforming growth factor beta receptor type II (dnTGF-RII) mice that develop both inflammatory bowel disease and autoimmune cholangitis and studied the role and the biological function of IL-22 by generating IL-22(-/-) dnTGF-RII mice. Our data suggest that the influence of IL-22 on autoimmunity is determined in part by the local microenvironment. In particular, IL-22 deficiency exacerbates tissue injury in inflammatory bowel disease, but has no influence on either the hepatocytes or cholangiocytes in the same model. These data take on particular significance in the previously defined effects of IL-17A, IL-12p40 and IL-23p19 deficiency and emphasize that, in colitis, there is a dominant role of IL-23/T helper type 17 (Th17) signalling. Furthermore, the levels of IL-22 are IL-23-dependent. The use of cytokine therapy in patients with autoimmune disease has significant potential, but must take into account the overlapping and often promiscuous effects that can theoretically exacerbate inflammation.  (日)    [継承]
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誌名 (必須): Clinical and Experimental Immunology (British Society for Immunology)
(pISSN: 0009-9104, eISSN: 1365-2249)

ISSN (任意): 1365-2249
ISSN: 0009-9104 (pISSN: 0009-9104, eISSN: 1365-2249)
Title: Clinical and experimental immunology
Title(ISO): Clin Exp Immunol
Supplier: British Society for Immunology
Publisher: Wiley Publishing
 (NLM Catalog  (Wiley  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 154 164 [継承]
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年月日 (必須): 西暦 2016年 6月 6日 (平成 28年 6月 6日) [継承]
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DOI (任意): 10.1111/cei.12806    (→Scopusで検索) [継承]
PMID (任意): 27148790    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.ELocationID: 10.1111/cei.12806  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) OtherID: PMC4955007 [Available on 08/01/17]  (日)    [継承]
4.(英) KeywordList.Keyword: IL-22  (日)    [継承]
5.(英) KeywordList.Keyword: IL-23  (日)    [継承]
6.(英) KeywordList.Keyword: cholangitis  (日)    [継承]
7.(英) KeywordList.Keyword: colitis  (日)    [継承]
8.(英) KeywordList.Keyword: primary biliary cirrhosis  (日)    [継承]

標準的な表示

和文冊子 ● G-X Yang, Y Sun, Koichi Tsuneyama, W Zhang, P S. C. Leung, X-S He, A A. Ansari, C Bowlus, W M. Ridgway and M E. Gershwin : Endogenous interleukin-22 protects against inflammatory bowel disease but not autoimmune cholangitis in dominant negative form of transforming growth factor beta receptor type II mice., Clinical and Experimental Immunology, Vol.185, No.2, 154-164, 2016.
欧文冊子 ● G-X Yang, Y Sun, Koichi Tsuneyama, W Zhang, P S. C. Leung, X-S He, A A. Ansari, C Bowlus, W M. Ridgway and M E. Gershwin : Endogenous interleukin-22 protects against inflammatory bowel disease but not autoimmune cholangitis in dominant negative form of transforming growth factor beta receptor type II mice., Clinical and Experimental Immunology, Vol.185, No.2, 154-164, 2016.

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