『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
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組織 (推奨):
著者 (必須): 1.中西 正 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.歯科保存学]/[徳島大学.病院.診療科.歯科.むし歯科(第一保存科)])
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2.向井 佳代
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3.細川 義隆 ([徳島大学.病院.診療科.歯科.むし歯科(第一保存科)])
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4.武川 大輔 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.歯科保存学]/[徳島大学.病院.診療科.歯科.むし歯科(第一保存科)])
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5.松尾 敬志
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題名 (必須): (英) Catechins inhibit vascular endothelial growth factor production and cyclooxygenase-2 expression in human dental pulp cells  (日)    [継承]
副題 (任意):
要約 (任意): (英) To investigate the effect of catechins on vascular endothelial growth factor (VEGF) production and cyclooxygenase-2 (COX-2) expression in human dental pulp cells (HDPC) stimulated with bacteria-derived factors or pro-inflammatory cytokines. Morphologically fibroblastic cells established from explant cultures of healthy human dental pulp tissues were used as HDPC. HDPC pre-treated with catechins, epigallocatechin-3-gallate (EGCG) or epicatechin gallate (ECG), were exposed to lipopolysaccharide (LPS), peptidoglycan (PG), interlukin-1β (IL-1β) or tumour necrosis factor-α (TNF-α). VEGF production was examined by enzyme-linked immunosorbent assay, and COX-2 expression was assessed by immunoblot. EGCG and ECG significantly reduced LPS- or PG-mediated VEGF production in the HDPC in a dose-dependent manner. EGCG also prevented IL-1β-mediated VEGF production. Although TNF-α did not enhance VEGF production in the dental pulp cells, treatment of 20 μg mL(-1) of EGCG decreased the level of VEGF. In addition, the catechins attenuated COX-2 expression induced by LPS and IL-1β. The up-regulated VEGF and COX-2 expressions in the HDPC stimulated with these bacteria-derived factors or IL-1β were diminished by the treatment of EGCG and ECG. These findings suggest that the catechins may be beneficial as an anti-inflammatory tool of the treatment for pulpal inflammation.  (日)    [継承]
キーワード (推奨): 1. (英) catechin (日) (読) [継承]
2. (英) cyclooxygenase-2 (日) (読) [継承]
3. (英) dental pulp (日) (読) [継承]
4. (英) vascular endothelial growth factor (日) (読) [継承]
発行所 (推奨):
誌名 (必須): International Endodontic Journal (British Endodontic Society/European Society of Endodontology)
(pISSN: 0143-2885, eISSN: 1365-2591)

ISSN (任意): 0143-2885
ISSN: 0143-2885 (pISSN: 0143-2885, eISSN: 1365-2591)
Title: International endodontic journal
Title(ISO): Int Endod J
Supplier: British Endodontic Society
Publisher: Blackwell
 (NLM Catalog  (Wiley  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 48 [継承]
(必須): 3 [継承]
(必須): 277 282 [継承]
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年月日 (必須): 西暦 2015年 3月 初日 (平成 27年 3月 初日) [継承]
URL (任意):
DOI (任意): 10.1111/iej.12312    (→Scopusで検索) [継承]
PMID (任意): 24847951    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.ELocationID: 10.1111/iej.12312  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]
4.(英) KeywordList.Keyword: catechin  (日)    [継承]
5.(英) KeywordList.Keyword: cyclooxygenase-2  (日)    [継承]
6.(英) KeywordList.Keyword: dental pulp  (日)    [継承]
7.(英) KeywordList.Keyword: vascular endothelial growth factor  (日)    [継承]

標準的な表示

和文冊子 ● Tadashi Nakanishi, Kayo Mukai, Yoshitaka Hosokawa, Daisuke Takegawa and Takashi Matsuo : Catechins inhibit vascular endothelial growth factor production and cyclooxygenase-2 expression in human dental pulp cells, International Endodontic Journal, Vol.48, No.3, 277-282, 2015.
欧文冊子 ● Tadashi Nakanishi, Kayo Mukai, Yoshitaka Hosokawa, Daisuke Takegawa and Takashi Matsuo : Catechins inhibit vascular endothelial growth factor production and cyclooxygenase-2 expression in human dental pulp cells, International Endodontic Journal, Vol.48, No.3, 277-282, 2015.

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