| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): |
| ○カテゴリ (推奨): |
| ○共著種別 (推奨): |
| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Inaba, H (日) (読)
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 2. | (英) Goto, H (日) (読)
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 3. | (英) Kasahara, K (日) (読)
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 4. | (英) Kumamoto, K (日) (読)
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| ○学籍番号 (推奨): |
| [継承] |
| 5. | 米村 重信 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.生理系.細胞生物学])
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| ○学籍番号 (推奨): |
| [継承] |
| 6. | (英) Inoko, A (日) (読)
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 7. | (英) Yamano, S (日) (読)
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 8. | (英) Wanibuchi, H (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 9. | (英) He, D (日) (読)
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 10. | (英) Goshima, N (日) (読)
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 11. | (英) Kiyono, T (日) (読)
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 12. | (英) Hirotsune, S (日) (読)
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 13. | (英) Inagaki, M (日) (読)
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| ○題名 (必須): | □ | (英) Ndel1 suppresses ciliogenesis in proliferating cells by regulating the trichoplein-Aurora A pathway. (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Primary cilia protrude from the surface of quiescent cells and disassemble at cell cycle reentry. We previously showed that ciliary reassembly is suppressed by trichoplein-mediated Aurora A activation pathway in growing cells. Here, we report that Ndel1, a well-known modulator of dynein activity, localizes at the subdistal appendage of the mother centriole, which nucleates a primary cilium. In the presence of serum, Ndel1 depletion reduces trichoplein at the mother centriole and induces unscheduled primary cilia formation, which is reverted by forced trichoplein expression or coknockdown of KCTD17 (an E3 ligase component protein for trichoplein). Serum starvation induced transient Ndel1 degradation, subsequent to the disappearance of trichoplein at the mother centriole. Forced expression of Ndel1 suppressed trichoplein degradation and axonemal microtubule extension during ciliogenesis, similar to trichoplein induction or KCTD17 knockdown. Most importantly, the proportion of ciliated and quiescent cells was increased in the kidney tubular epithelia of newborn Ndel1-hypomorphic mice. Thus, Ndel1 acts as a novel upstream regulator of the trichoplein-Aurora A pathway to inhibit primary cilia assembly. (日)
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| ○キーワード (推奨): | 1. | (英) Adaptor Proteins, Signal Transducing (日) (読)
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| 2. | (英) Animals (日) (読)
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| 3. | (英) Animals, Newborn (日) (読)
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| 4. | (英) Aurora Kinase A (日) (読)
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| 5. | (英) Carrier Proteins (日) (読)
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| 6. | (英) Cell Cycle Checkpoints (日) (読)
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| 7. | (英) Cell Proliferation (日) (読)
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| 8. | (英) Centrioles (日) (読)
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| 9. | (英) Cilia (日) (読)
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| 10. | (英) Epithelial Cells (日) (読)
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| 11. | (英) Genotype (日) (読)
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| 12. | (英) HeLa Cells (日) (読)
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| 13. | (英) Humans (日) (読)
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| 14. | (英) Kidney Tubules (日) (読)
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| 15. | (英) Mice (日) (読)
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| 16. | (英) Mice, Knockout (日) (読)
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| 17. | (英) Microtubules (日) (読)
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| 18. | (英) Phenotype (日) (読)
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| 19. | (英) Protein Stability (日) (読)
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| 20. | (英) Proteolysis (日) (読)
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| 21. | (英) RNA Interference (日) (読)
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| 22. | (英) Signal Transduction (日) (読)
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| 23. | (英) Swiss 3T3 Cells (日) (読)
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| 24. | (英) Time Factors (日) (読)
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| 25. | (英) Transfection (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | The Journal of Cell Biology (Rockefeller Institute/American Society for Cell Biology)
(pISSN: 0021-9525, eISSN: 1540-8140)
| ○ISSN (任意): | □ | 1540-8140
ISSN: 0021-9525
(pISSN: 0021-9525, eISSN: 1540-8140) Title: The Journal of cell biologyTitle(ISO): J Cell BiolPublisher: Rockefeller University Press (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 212
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| ○号 (必須): | □ | 4
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| ○頁 (必須): | □ | 409 423
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2016年 2月 15日 (平成 28年 2月 15日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1083/jcb.201507046 (→Scopusで検索)
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| ○PMID (任意): | □ | 26880200 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS (任意): | □ | 000370488700007
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| ○Scopus (任意): | □ | 2-s2.0-84959468418
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| ○評価値 (任意): |
| ○被引用数 (任意): |
| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1083/jcb.201507046 (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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| 4. | (英) OtherID: PMC4754717 (日)
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