| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): |
| ○カテゴリ (推奨): |
| ○共著種別 (推奨): | □ | 徳島大学以外での国内共著 (徳島大学以外でのある一つの国に属する複数機関による共同研究 (国外研究者を含まない))
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Ozone, C (日) (読)
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| 2. | (英) Suga, H (日) (読)
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 3. | (英) Eiraku, M (日) (読)
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 4. | (英) Kagoshima, T (日) (読)
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| 5. | 米村 重信 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.生理系.細胞生物学])
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| ○学籍番号 (推奨): |
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| 6. | (英) Takata, N (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 7. | (英) Oiso, Y (日) (読)
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| 8. | (英) Tsuji, T (日) (読)
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| 9. | (英) Sasai, Y (日) (読)
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| ○題名 (必須): | □ | (英) Functional anterior pituitary generated in self-organizing culture of human embryonic stem cells. (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Anterior pituitary is critical for endocrine systems. Its hormonal responses to positive and negative regulators are indispensable for homeostasis. For this reason, generating human anterior pituitary tissue that retains regulatory hormonal control in vitro is an important step for the development of cell transplantation therapy for pituitary diseases. Here we achieve this by recapitulating mouse pituitary development using human embryonic stem cells. We find that anterior pituitary self-forms in vitro following the co-induction of hypothalamic and oral ectoderm. The juxtaposition of these tissues facilitated the formation of pituitary placode, which subsequently differentiated into pituitary hormone-producing cells. They responded normally to both releasing and feedback signals. In addition, after transplantation into hypopituitary mice, the in vitro-generated corticotrophs rescued physical activity levels and survival of the hosts. Thus, we report a useful methodology for the production of regulator-responsive human pituitary tissue that may benefit future studies in regenerative medicine. (日)
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| ○キーワード (推奨): | 1. | (英) Adrenocorticotropic Hormone (日) (読)
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| 2. | (英) Animals (日) (読)
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| 3. | (英) Cell Culture Techniques (日) (読)
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| 4. | (英) Corticotrophs (日) (読)
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| 5. | (英) Embryonic Development (日) (読)
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| 6. | (英) Embryonic Stem Cells (日) (読)
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| 7. | (英) Growth Hormone (日) (読)
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| 8. | (英) Humans (日) (読)
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| 9. | (英) Hypopituitarism (日) (読)
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| 10. | (英) Mice (日) (読)
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| 11. | (英) Pituitary Gland, Anterior (日) (読)
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| 12. | (英) Tissue Engineering (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Nature Communications ([Nature Publishing Group])
(eISSN: 2041-1723)
| ○ISSN (任意): | □ | 2041-1723
ISSN: 2041-1723
(eISSN: 2041-1723) Title: Nature communicationsTitle(ISO): Nat CommunPublisher: Nature Portfolio (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 7
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| ○号 (必須): | □ |
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| ○頁 (必須): | □ | 10351 10351
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2016年 1月 14日 (平成 28年 1月 14日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1038/ncomms10351 (→Scopusで検索)
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| ○PMID (任意): | □ | 26762480 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS (任意): | □ | 000369019000005
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| ○Scopus (任意): | □ | 2-s2.0-84954138949
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| ○機関リポジトリ : | □ | 112430
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| ○評価値 (任意): |
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| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1038/ncomms10351 (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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| 4. | (英) OtherID: PMC4735598 (日)
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