| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): |
| ○カテゴリ (推奨): |
| ○共著種別 (推奨): | □ | 徳島大学以外での国際共著 (徳島大学以外での複数の国の研究機関による共同研究)
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Shinohara, K (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| 2. | (英) Chen, D (日) (読)
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| 3. | (英) Nishida, T (日) (読)
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| ○学籍番号 (推奨): |
| [継承] |
| 4. | (英) Misaki, K (日) (読)
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| 5. | 米村 重信 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.生理系.細胞生物学])
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| ○貢献度 (任意): |
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| 6. | (英) Hamada, H (日) (読)
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| ○題名 (必須): | □ | (英) Absence of Radial Spokes in Mouse Node Cilia Is Required for Rotational Movement but Confers Ultrastructural Instability as a Trade-Off. (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Determination of left-right asymmetry in mouse embryos is established by a leftward fluid flow that is generated by clockwise rotation of node cilia. How node cilia achieve stable unidirectional rotation has remained unknown, however. Here we show that brief exposure to the microtubule-stabilizing drug paclitaxel (Taxol) induces randomly directed rotation and changes the ultrastructure of node cilia. In vivo observations and a computer simulation revealed that a regular 9+0 arrangement of doublet microtubules is essential for stable unidirectional rotation of node cilia. The 9+2 motile cilia of the airway, which manifest planar beating, are resistant to Taxol treatment. However, the airway cilia of mice lacking the radial spoke head protein Rsph4a undergo rotational movement instead of planar beating, are prone to microtubule rearrangement, and are sensitive to Taxol. Our results suggest that the absence of radial spokes allows node cilia to rotate unidirectionally but, as a trade-off, renders them ultrastructurally fragile. (日)
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| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
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| 2. | (英) Body Patterning (日) (読)
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| 3. | (英) Cilia (日) (読)
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| 4. | (英) Embryo, Mammalian (日) (読)
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| 5. | (英) Embryonic Development (日) (読)
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| 6. | (英) Mice (日) (読)
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| 7. | (英) Microtubules (日) (読)
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| 8. | (英) Paclitaxel (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Developmental Cell (Cell Press)
(pISSN: 1534-5807, eISSN: 1878-1551)
| ○ISSN (任意): | □ | 1878-1551
ISSN: 1534-5807
(pISSN: 1534-5807, eISSN: 1878-1551) Title: Developmental cellTitle(ISO): Dev CellPublisher: Cell Press (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 35
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| ○号 (必須): | □ | 2
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| ○頁 (必須): | □ | 236 246
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2015年 10月 26日 (平成 27年 10月 26日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1016/j.devcel.2015.10.001 (→Scopusで検索)
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| ○PMID (任意): | □ | 26506310 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS (任意): | □ | 000363868300010
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| ○Scopus (任意): | □ | 2-s2.0-84945124366
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| ○評価値 (任意): |
| ○被引用数 (任意): |
| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1016/j.devcel.2015.10.001 (日)
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| 2. | (英) Article.ELocationID: S1534-5807(15)00628-0 (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 4. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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