| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): |
| ○カテゴリ (推奨): |
| ○共著種別 (推奨): | □ | 徳島大学以外での国内共著 (徳島大学以外でのある一つの国に属する複数機関による共同研究 (国外研究者を含まない))
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Takeuchi, M (日) (読)
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| ○学籍番号 (推奨): |
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| 2. | (英) Yamaguchi, S (日) (読)
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| 3. | 米村 重信 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.生理系.細胞生物学])
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| ○学籍番号 (推奨): |
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| 4. | (英) Kakiguchi, K (日) (読)
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| 5. | (英) Sato, Y (日) (読)
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| [継承] |
| 6. | (英) Higashiyama, T (日) (読)
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| [継承] |
| 7. | (英) Shimizu, T (日) (読)
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| [継承] |
| 8. | (英) Habi, M (日) (読)
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| ○題名 (必須): | □ | (英) Type IV Collagen Controls the Axogenesis of Cerebellar Granule Cells by Regulating Basement Membrane Integrity in Zebrafish. (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Granule cells (GCs) are the major glutamatergic neurons in the cerebellum, and GC axon formation is an initial step in establishing functional cerebellar circuits. In the zebrafish cerebellum, GCs can be classified into rostromedial and caudolateral groups, according to the locations of their somata in the corresponding cerebellar lobes. The axons of the GCs in the caudolateral lobes terminate on crest cells in the dorsal hindbrain, as well as forming en passant synapses with Purkinje cells in the cerebellum. In the zebrafish mutant shiomaneki, the caudolateral GCs extend aberrant axons. Positional cloning revealed that the shiomaneki (sio) gene locus encodes Col4a6, a subunit of type IV collagen, which, in a complex with Col4a5, is a basement membrane (BM) component. Both col4a5 and col4a6 mutants displayed similar abnormalities in the axogenesis of GCs and retinal ganglion cells (RGCs). Although type IV collagen is reported to control axon targeting by regulating the concentration gradient of an axonal guidance molecule Slit, Slit overexpression did not affect the GC axons. The structure of the BM surrounding the tectum and dorsal hindbrain was disorganized in the col4a5 and col4a6 mutants. Moreover, the abnormal axogenesis of the caudolateral GCs and the RGCs was coupled with aberrant BM structures in the type IV collagen mutants. The regrowth of GC axons after experimental ablation revealed that the original and newly formed axons displayed similar branching and extension abnormalities in the col4a6 mutants. These results collectively suggest that type IV collagen controls GC axon formation by regulating the integrity of the BM, which provides axons with the correct path to their targets. (日)
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| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
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| 2. | (英) Axons (日) (読)
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| 3. | (英) Basement Membrane (日) (読)
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| 4. | (英) Cerebellum (日) (読)
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| 5. | (英) Collagen Type IV (日) (読)
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| 6. | (英) Extracellular Matrix (日) (読)
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| 7. | (英) Nerve Tissue Proteins (日) (読)
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| 8. | (英) Purkinje Cells (日) (読)
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| 9. | (英) Retinal Ganglion Cells (日) (読)
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| 10. | (英) Zebrafish (日) (読)
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| 11. | (英) Zebrafish Proteins (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | PLoS Genetics (Public Library of Science)
(pISSN: 1553-7390, eISSN: 1553-7404)
| ○ISSN (任意): | □ | 1553-7404
ISSN: 1553-7390
(pISSN: 1553-7390, eISSN: 1553-7404) Title: PLoS geneticsTitle(ISO): PLoS GenetPublisher: PLOS (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 11
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| ○号 (必須): | □ |
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| ○頁 (必須): | □ | e1005587 e1005587
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2015年 10月 9日 (平成 27年 10月 9日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1371/journal.pgen.1005587 (→Scopusで検索)
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| ○PMID (任意): | □ | 26451951 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS (任意): | □ | 000364401600051
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| ○Scopus (任意): | □ | 2-s2.0-84946592981
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| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1371/journal.pgen.1005587 (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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| 4. | (英) OtherID: PMC4599943 (日)
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