| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): |
| ○カテゴリ (推奨): |
| ○共著種別 (推奨): | □ | 徳島大学以外での国際共著 (徳島大学以外での複数の国の研究機関による共同研究)
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Nagai, H (日) (読)
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| 2. | (英) Sezaki, M (日) (読)
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| 3. | (英) Kakiguchi, K (日) (読)
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| 4. | (英) Nakaya, Y (日) (読)
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| 5. | (英) Lee, HC (日) (読)
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| 6. | (英) Lather, R (日) (読)
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| [継承] |
| 7. | (英) Sasanami, T (日) (読)
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| [継承] |
| 8. | (英) Han, JK (日) (読)
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| 9. | 米村 重信 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.生理系.細胞生物学])
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| 10. | (英) Sheng, G (日) (読)
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| ○題名 (必須): | □ | (英) Cellular analysis of cleavage-stage chick embryos reveals hidden conservation in vertebrate early development. (日)
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| ○要約 (任意): | □ | (英) Birds and mammals, phylogenetically close amniotes with similar post-gastrula development, exhibit little conservation in their post-fertilization cleavage patterns. Data from the mouse suggest that cellular morphogenesis and molecular signaling at the cleavage stage play important roles in lineage specification at later (blastula and gastrula) stages. Very little is known, however, about cleavage-stage chick embryos, owing to their poor accessibility. This period of chick development takes place before egg-laying and encompasses several fundamental processes of avian embryology, including zygotic gene activation (ZGA) and blastoderm cell-layer increase. We have carried out morphological and cellular analyses of cleavage-stage chick embryos covering the first half of pre-ovipositional development, from Eyal-Giladi and Kochav stage (EGK-) I to EGK-V. Scanning electron microscopy revealed remarkable subcellular details of blastomere cellularization and subgerminal cavity formation. Phosphorylated RNA polymerase II immunostaining showed that ZGA in the chick starts at early EGK-III during the 7th to 8th nuclear division cycle, comparable with the time reported for other yolk-rich vertebrates (e.g. zebrafish and Xenopus). The increase in the number of cell layers after EGK-III is not a direct consequence of oriented cell division. Finally, we present evidence that, as in the zebrafish embryo, a yolk syncytial layer is formed in the avian embryo after EGK-V. Our data suggest that several fundamental features of cleavage-stage development in birds resemble those in yolk-rich anamniote species, revealing conservation in vertebrate early development. Whether this conservation lends morphogenetic support to the anamniote-to-amniote transition in evolution or reflects developmental plasticity in convergent evolution awaits further investigation. (日)
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| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
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| 2. | (英) Cell Nucleus (日) (読)
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| 3. | (英) Chick Embryo (日) (読)
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| 4. | (英) Cleavage Stage, Ovum (日) (読)
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| 5. | (英) Egg Yolk (日) (読)
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| 6. | (英) Embryo, Nonmammalian (日) (読)
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| 7. | (英) Embryonic Development (日) (読)
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| 8. | (英) Gene Expression Regulation, Developmental (日) (読)
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| 9. | (英) Giant Cells (日) (読)
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| 10. | (英) Mitosis (日) (読)
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| 11. | (英) Phosphorylation (日) (読)
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| 12. | (英) Phosphoserine (日) (読)
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| 13. | (英) RNA Polymerase II (日) (読)
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| 14. | (英) Vertebrates (日) (読)
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| 15. | (英) Zygote (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Development ([The Company of Biologists Limited])
(pISSN: 0950-1991, eISSN: 1477-9129)
| ○ISSN (任意): | □ | 1477-9129
ISSN: 0950-1991
(pISSN: 0950-1991, eISSN: 1477-9129) Title: Development (Cambridge, England)Title(ISO): DevelopmentPublisher: Company of Biologists (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 142
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| ○号 (必須): | □ | 7
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| ○頁 (必須): | □ | 1279 1286
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2015年 4月 初日 (平成 27年 4月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1242/dev.118604 (→Scopusで検索)
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| ○PMID (任意): | □ | 25742796 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS (任意): | □ | 000351698000007
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| ○Scopus (任意): | □ | 2-s2.0-84930703771
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| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1242/dev.118604 (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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| 4. | (英) OtherID: PMC4378249 (日)
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| 5. | (英) KeywordList.Keyword: Amniote (日)
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| 6. | (英) KeywordList.Keyword: Cellularization (日)
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| 7. | (英) KeywordList.Keyword: Chick (日)
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| 8. | (英) KeywordList.Keyword: Cleavage (日)
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| 9. | (英) KeywordList.Keyword: Yolk syncytium (日)
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| 10. | (英) KeywordList.Keyword: Zygotic gene activation (日)
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