『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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登録内容 (EID=315714)

EID=315714EID:315714, Map:0, LastModified:2016年8月29日(月) 15:20:52, Operator:[大家 隆弘], Avail:TRUE, Censor:承認済, Owner:[米村 重信], Read:継承, Write:継承, Delete:継承.
○種別 (必須): □学術論文 (審査論文) [継承]
○言語 (必須): □英語 [継承]
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○審査 (推奨): □Peer Review [継承]
○カテゴリ (推奨):
○共著種別 (推奨):
○学究種別 (推奨):
○組織 (推奨):
○著者 (必須): 1. (英) Nakanishi, K (日) (読)
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2. (英) Kakiguchi, K (日) (読)
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3.米村 重信 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.生理系.細胞生物学])
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4. (英) Nakano, A (日) (読)
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5. (英) Morishima, N (日) (読)
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○題名 (必須): □(英) Transient Ca2+ depletion from the endoplasmic reticulum is critical for skeletal myoblast differentiation.  (日)    [継承]
○副題 (任意):
○要約 (任意): □(英) Endoplasmic reticulum (ER) stress is a cellular condition in which unfolded proteins accumulate in the ER because of various but specific causes. Physiologic ER stress occurs transiently during myoblast differentiation, and although its cause remains unknown, it plays a critical role in myofiber formation. To examine the mechanism underlying ER stress, we monitored ER morphology during differentiation of murine myoblasts. Novel ER-derived structures transiently appeared prior to myoblast fusion both in vitro and in vivo. Electron microscopy studies revealed that these structures consisted of pseudoconcentric ER cisternae with narrow lumens. Similar structures specifically formed by pharmacologically induced ER Ca(2+) depletion, and inhibition of ER Ca(2+) efflux channels in differentiating myoblasts considerably suppressed ER-specific deformation and ER stress signaling. Thus, we named the novel structures stress-activated response to Ca(2+) depletion (SARC) bodies. Prior to SARC body formation, stromal interaction molecule 1 (STIM1), an ER Ca(2+) sensor protein, formed ER Ca(2+) depletion-specific clusters. Furthermore, myoblast differentiation manifested by myoblast fusion did not proceed under the same conditions as inhibition of ER Ca(2+) depletion. Altogether, these observations suggest that ER Ca(2+) depletion is a prerequisite for myoblast fusion, causing both physiologic ER stress signaling and SARC body formation.  (日)    [継承]
○キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Blotting, Western (日) (読) [継承]
3. (英) Calcium (日) (読) [継承]
4. (英) Calcium Channels (日) (読) [継承]
5. (英) Cell Differentiation (日) (読) [継承]
6. (英) Cell Membrane (日) (読) [継承]
7. (英) Cells, Cultured (日) (読) [継承]
8. (英) Endoplasmic Reticulum (日) (読) [継承]
9. (英) Endoplasmic Reticulum Stress (日) (読) [継承]
10. (英) Immunoenzyme Techniques (日) (読) [継承]
11. (英) Mice (日) (読) [継承]
12. (英) Myoblasts, Skeletal (日) (読) [継承]
13. (英) Signal Transduction (日) (読) [継承]
○発行所 (推奨):
○誌名 (必須): □The FASEB journal ([Federation of American Societies for Experimental Biology])
(pISSN: 0892-6638, eISSN: 1530-6860)

○ISSN (任意): □1530-6860
ISSN: 0892-6638 (pISSN: 0892-6638, eISSN: 1530-6860)
Title: FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Title(ISO): FASEB J
Supplier: Federation of American Societies for Experimental Biology
Publisher: Federation of American Societies for Experimental Biology
 (NLM Catalog)   (Wiley)   (Scopus)   (CrossRef)  (Scopus information is found. [need login])
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○巻 (必須): □29 [継承]
○号 (必須): □5 [継承]
○頁 (必須): □2137 2149 [継承]
○都市 (任意):
○年月日 (必須): □西暦 2015年 5月 初日 (平成 27年 5月 初日) [継承]
○URL (任意):
○DOI (任意): □10.1096/fj.14-261529    (→Scopusで検索) [継承]
○PMID (任意): □25678623    (→Scopusで検索) [継承]
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○備考 (任意): 1.(英) Article.ELocationID: 10.1096/fj.14-261529  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]
4.(英) KeywordList.Keyword: ER deformation  (日)    [継承]
5.(英) KeywordList.Keyword: ER stress  (日)    [継承]
6.(英) KeywordList.Keyword: STIM1  (日)    [継承]
7.(英) KeywordList.Keyword: myoblast fusion  (日)    [継承]

標準的な表示

和文冊子 ● K Nakanishi, K Kakiguchi, Shigenobu Yonemura, A Nakano and N Morishima : Transient Ca2+ depletion from the endoplasmic reticulum is critical for skeletal myoblast differentiation., The FASEB journal, Vol.29, No.5, 2137-2149, 2015.
欧文冊子 ● K Nakanishi, K Kakiguchi, Shigenobu Yonemura, A Nakano and N Morishima : Transient Ca2+ depletion from the endoplasmic reticulum is critical for skeletal myoblast differentiation., The FASEB journal, Vol.29, No.5, 2137-2149, 2015.

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