『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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著者 (必須): 1. (英) Oura Kanna (日) (読)
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2. (英) Otsuka Airi (日) (読)
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3.志内 哲也 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.生理系.統合生理学])
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4.近久 幸子 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.生理系.統合生理学])
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5.清水 紀之
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6.勢井 宏義 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.生理系.統合生理学])
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題名 (必須): (英) Late feeding in the active period decreases slow-wave activity.  (日)    [継承]
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要約 (任意): (英) Sleep and feeding behaviors closely interact to maintain energy homeostasis. While it is known that sleep disorders can lead to various metabolic issues such as insulin resistance, the mechanism for this effect is poorly understood. We thus investigated whether different feeding rhythms during the active period affect sleep-wake regulation. For 2weeks, mice were randomly assigned to 1 of 3 feeding schedules as follows: free access to lab chow during the active period (ZT12-24, Ad-lib group), free access to lab chow during the first half of the active period (ZT12-18; Morning group), or free access to lab chow during the second half of the active period (ZT18-24, Evening group). Food intake, body weight, body temperature, locomotor activity, and sleep were evaluated. The hypothalamus and cerebral cortex were examined post-mortem. No alterations in food intake or body weight were observed among the 3 groups. The Evening group showed lower slow-wave activity (SWA) than the other 2 groups, in addition to higher expression of orexin mRNA in the hypothalamus and higher concentrations of dopamine and its metabolites in the cerebral cortex. AMPK phosphorylation was increased in the hypothalamus of mice in the Evening group; however, AMPK inhibition had no effect on SWA. We concluded that late feeding reduces SWA in NREM sleep via a mechanism that involves orexin-mediated arousal in the hypothalamus and elevated monoamines in the cerebral cortex. These data have important implications for the relationship between sleep-wake disturbances and metabolic disorders.  (日)    [継承]
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誌名 (必須): Life Sciences ([Elsevier])
(pISSN: 0024-3205, eISSN: 1879-0631)

ISSN (任意): 1879-0631
ISSN: 0024-3205 (pISSN: 0024-3205, eISSN: 1879-0631)
Title: Life sciences
Title(ISO): Life Sci.
Publisher: Elsevier BV
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 160 [継承]
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(必須): 18 26 [継承]
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年月日 (必須): 西暦 2016年 7月 17日 (平成 28年 7月 17日) [継承]
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DOI (任意): 10.1016/j.lfs.2016.07.005    (→Scopusで検索) [継承]
PMID (任意): 27436545    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.ELocationID: 10.1016/j.lfs.2016.07.005  (日)    [継承]
2.(英) Article.ELocationID: S0024-3205(16)30415-5  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
4.(英) KeywordList.Keyword: AMPK  (日)    [継承]
5.(英) KeywordList.Keyword: Arousal  (日)    [継承]
6.(英) KeywordList.Keyword: Feeding rhythm  (日)    [継承]
7.(英) KeywordList.Keyword: Orexin  (日)    [継承]
8.(英) KeywordList.Keyword: Sleep  (日)    [継承]

標準的な表示

和文冊子 ● Kanna Oura, Airi Otsuka, Tetsuya Shiuchi, Sachiko Chikahisa, Noriyuki Shimizu and Hiroyoshi Sei : Late feeding in the active period decreases slow-wave activity., Life Sciences, Vol.160, (号), 18-26, 2016.
欧文冊子 ● Kanna Oura, Airi Otsuka, Tetsuya Shiuchi, Sachiko Chikahisa, Noriyuki Shimizu and Hiroyoshi Sei : Late feeding in the active period decreases slow-wave activity., Life Sciences, Vol.160, (号), 18-26, 2016.

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