『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=315285EID:315285, Map:0, LastModified:2016年12月9日(金) 14:32:24, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[志内 哲也], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨): 単独著作 (徳島大学内の単一の研究グループ(研究室等)内の研究 (単著も含む)) [継承]
学究種別 (推奨): 博士課程学生による研究報告 [継承]
組織 (推奨):
著者 (必須): 1. (英) Otsuka Airi (日) (読)
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学籍番号 (推奨):
[継承]
2.志内 哲也 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.生理系.統合生理学])
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3.近久 幸子 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.生理系.統合生理学])
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学籍番号 (推奨):
[継承]
4.清水 紀之
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5.勢井 宏義 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.生理系.統合生理学])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Voluntary exercise and increased food intake after mild chronic stress improve social avoidance behavior in mice.  (日)    [継承]
副題 (任意):
要約 (任意): (英) It is well-established that exercise can influence psychological conditions, cognitive function, and energy metabolism in peripheral tissues including the skeletal muscle. However, it is not clear whether exercise can influence social interaction with others and alleviate defeat stress. This study investigated the effect of voluntary wheel running on impaired social interaction induced by chronic social defeat stress (SDS) using the resident-intruder social defeat model. Mice were divided into three groups: control, stress alone, and stress+exercise. SDS was performed by exposing C57BL/6 mice to retired ICR mice for 2.5 min. The C57BL/6 mice were continuously defeated by these resident (aggressor) mice and, following 5 days of SDS, experienced 2 days of rest with no SDS. Mice in the stress+exercise group were allowed to voluntarily run on a wheel for 2h after every SDS exposure. Two weeks later, compared to the control group, the stress group showed a higher ratio of time spent in the corner zone of a social interaction paradigm even though SDS did not elicit depressive- and anxiety-like behaviors. We also observed that voluntary exercise, which did not affect muscle weight and gene expression, decreased social avoidance behavior of stressed mice without clear changes in brain monoamine levels. Interestingly, food intake in the stress+exercise group was the greatest among the three groups. To test the effect of the exercise-induced increase in food intake on social behavior, we set up a pair-fed group where food intake was restricted. We then compared these mice to mice in the stress alone group. We found that the ratio of time spent in the corner zone of the social interaction test was not different between ad libitum- and pair-fed groups, although pair-fed mice spent more time in the corner zone when an aggressor mouse was present than when it was absent. In addition, pair-feeding did not show exercise-induced reductions of adrenal gland weight and enhanced the loss of body fat. Our findings indicate that voluntary exercise reduces social avoidance behavior induced by SDS. Further, we determined that SDS and exercise-induced increases in food intake partially influence energy metabolism and social avoidance behavior.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Anxiety (日) (読) [継承]
3. (英) Brain (日) (読) [継承]
4. (英) Depression (日) (読) [継承]
5. (英) Disease Models, Animal (日) (読) [継承]
6. (英) Dominance-Subordination (日) (読) [継承]
7. (英) Dopamine (日) (読) [継承]
8. (英) Eating (日) (読) [継承]
9. (英) Gene Expression (日) (読) [継承]
10. (英) Male (日) (読) [継承]
11. (英) Mice, Inbred C57BL (日) (読) [継承]
12. (英) Mice, Inbred ICR (日) (読) [継承]
13. (英) Motor Activity (日) (読) [継承]
14. (英) Running (日) (読) [継承]
15. (英) Serotonin (日) (読) [継承]
16. (英) Social Behavior (日) (読) [継承]
17. (英) Stress, Psychological (日) (読) [継承]
18. (英) Volition (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Physiology & Behavior ([Brain Research Publications])
(pISSN: 0031-9384, eISSN: 1873-507X)

ISSN (任意): 1873-507X
ISSN: 0031-9384 (pISSN: 0031-9384, eISSN: 1873-507X)
Title: Physiology & behavior
Title(ISO): Physiol. Behav.
Publisher: Elsevier BV
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 151 [継承]
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(必須): 264 271 [継承]
都市 (任意):
年月日 (必須): 西暦 2015年 7月 29日 (平成 27年 7月 29日) [継承]
URL (任意):
DOI (任意): 10.1016/j.physbeh.2015.07.024    (→Scopusで検索) [継承]
PMID (任意): 26232088    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意): 000362602600033 [継承]
Scopus (任意): 2-s2.0-84939498491 [継承]
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備考 (任意): 1.(英) Article.ELocationID: 10.1016/j.physbeh.2015.07.024  (日)    [継承]
2.(英) Article.ELocationID: S0031-9384(15)30038-X  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
4.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]
5.(英) KeywordList.Keyword: Food intake  (日)    [継承]
6.(英) KeywordList.Keyword: Social avoidance  (日)    [継承]
7.(英) KeywordList.Keyword: Social defeat stress  (日)    [継承]
8.(英) KeywordList.Keyword: Voluntary exercise  (日)    [継承]

標準的な表示

和文冊子 ● Airi Otsuka, Tetsuya Shiuchi, Sachiko Chikahisa, Noriyuki Shimizu and Hiroyoshi Sei : Voluntary exercise and increased food intake after mild chronic stress improve social avoidance behavior in mice., Physiology & Behavior, Vol.151, (号), 264-271, 2015.
欧文冊子 ● Airi Otsuka, Tetsuya Shiuchi, Sachiko Chikahisa, Noriyuki Shimizu and Hiroyoshi Sei : Voluntary exercise and increased food intake after mild chronic stress improve social avoidance behavior in mice., Physiology & Behavior, Vol.151, (号), 264-271, 2015.

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