| ○種別 (必須): | □ | 学術論文 (審査論文)
| [継承] |
| ○言語 (必須): | □ | 英語
| [継承] |
| ○招待 (推奨): |
| ○審査 (推奨): |
| ○カテゴリ (推奨): | □ | 研究
| [継承] |
| ○共著種別 (推奨): | □ | 単独著作 (徳島大学内の単一の研究グループ(研究室等)内の研究 (単著も含む))
| [継承] |
| ○学究種別 (推奨): |
| ○組織 (推奨): | 1. | 徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔分子病態学 (2015年4月1日〜)
| [継承] |
| ○著者 (必須): | 1. | 山田 安希子
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 2. | (英) Ushio Aya (日) 牛尾 綾 (読) うしお あや
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): | □ | ****
| [ユーザ] |
| [継承] |
| 3. | 新垣 理恵子
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 4. | 常松 貴明 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔分子病態学])
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 5. | 工藤 保誠 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔生命科学])
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 6. | 林 良夫
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 7. | 石丸 直澄 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔分子病態学])
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| ○題名 (必須): | □ | (英) Impaired expansion of regulatory T cells in a neonatal thymectomy-induced autoimmune mouse model. (日)
| [継承] |
| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Neonatal thymectomy in certain mouse strains is known to induce organ-specific autoimmunity due to impaired functions of T cells, including Foxp3(+) regulatory T (Treg) cells in the thymus. The precise mechanism underlying the induction of autoimmunity by neonatal thymectomy remains unclear. One possibility is that depletion of Treg cells breaks down peripheral tolerance. We examined the functions of Treg cells by using a murine Sjögren syndrome model of NFS/sld mice that underwent neonatal thymectomy. The ratio of Treg cells to effector memory phenotype T cells in thymectomy mice was significantly lower than that of nonthymectomy mice. In addition, in vitro induction of peripherally induced Treg cells by transforming growth factor-β (TGF-β) using naive T cells from Sjögren syndrome model mice was severely impaired. The mRNA expression of TGF-β receptor I and II and Smad3 and -4 in the TGF-β-induced signal transduction pathway of Treg cells in this Sjögren syndrome model were lower than those of control mice. In addition, Treg cells in this Sjögren syndrome model exhibited an interferon-γ-producing Th1-like phenotype that resembled effector T cells. In conclusion, these results suggest that abnormal expansion and differentiation of Treg cells and inflammatory cytokines produced by Treg cells contribute to the development of autoimmunity. (日)
| [継承] |
| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
| [継承] |
| 2. | (英) Animals, Newborn (日) (読)
| [継承] |
| 3. | (英) Autoimmunity (日) (読)
| [継承] |
| 4. | (英) Cell Differentiation (日) (読)
| [継承] |
| 5. | (英) Cytokines (日) (読)
| [継承] |
| 6. | (英) Disease Models, Animal (日) (読)
| [継承] |
| 7. | (英) Female (日) (読)
| [継承] |
| 8. | (英) Interferon-gamma (日) (読)
| [継承] |
| 9. | (英) Mice (日) (読)
| [継承] |
| 10. | (英) Mice, Inbred C57BL (日) (読)
| [継承] |
| 11. | (英) Mutation (日) (読)
| [継承] |
| 12. | (英) Protein-Serine-Threonine Kinases (日) (読)
| [継承] |
| 13. | (英) Receptors, Transforming Growth Factor beta (日) (読)
| [継承] |
| 14. | (英) Specific Pathogen-Free Organisms (日) (読)
| [継承] |
| 15. | (英) T-Lymphocytes, Regulatory (日) (読)
| [継承] |
| 16. | (英) Thymectomy (日) (読)
| [継承] |
| 17. | (英) Transforming Growth Factor beta (日) (読)
| [継承] |
| ○発行所 (推奨): |
| ○誌名 (必須): | □ | The American Journal of Pathology ([American Society for Investigative Pathology])
(pISSN: 0002-9440, eISSN: 1525-2191)
| ○ISSN (任意): | □ | 1525-2191
ISSN: 0002-9440
(pISSN: 0002-9440, eISSN: 1525-2191) Title: The American journal of pathologyTitle(ISO): Am J PatholPublisher: American Society for Investigative Pathology (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
| [継承] |
| ○巻 (必須): | □ | 185
| [継承] |
| ○号 (必須): | □ | 11
| [継承] |
| ○頁 (必須): | □ | 2886 2897
| [継承] |
| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2015年 11月 初日 (平成 27年 11月 初日)
| [継承] |
| ○URL (任意): |
| ○DOI (任意): | □ | 10.1016/j.ajpath.2015.07.007 (→Scopusで検索)
| [継承] |
| ○PMID (任意): | □ | 26343329 (→Scopusで検索)
| [継承] |
| ○CRID (任意): |
| ○WOS (任意): |
| ○Scopus (任意): |
| ○評価値 (任意): |
| ○被引用数 (任意): |
| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1016/j.ajpath.2015.07.007 (日)
| [継承] |
| 2. | (英) Article.ELocationID: S0002-9440(15)00435-6 (日)
| [継承] |
| 3. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
| [継承] |
| 4. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
| [継承] |