『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=315060EID:315060, Map:0, LastModified:2017年5月23日(火) 15:58:12, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[宇都 義浩], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨): 国内共著 (徳島大学内研究者と国内(学外)研究者との共同研究 (国外研究者を含まない)) [継承]
学究種別 (推奨):
組織 (推奨): 1.徳島大学.大学院生物資源産業学研究部 (2016年4月1日〜) [継承]
著者 (必須): 1.森本 幸生
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2.永澤 秀子 (岐阜薬科大学/->個人[紺世 秀子])
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3.宇都 義浩 ([徳島大学.大学院社会産業理工学研究部.生物資源産業学域.応用生命系.応用生物資源学分野]/[徳島大学.生物資源産業学部.生物資源産業学科.応用生命講座])
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4. (英) Chatake Toshiyuki (日) (読)
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5.堀 均
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題名 (必須): (英) Structural Insight Into Protein Binding of Boron Tracedrug UTX-97 Revealed by the Co-Crystal Structure With Lysozyme at 1.26 Å Resolution  (日)    [継承]
副題 (任意):
要約 (任意): (英) Boron neutron capture therapy (BNCT) is one of the numbers of radiotherapies for treatment of certain cancers. The ability of low-dose irradiation with neutrons or radioactive beams to provide an acceptable quality of life is an objective which has not yet been achieved; therefore it will be necessary to increase the efficiency of the neutron capture reaction by lower dose irradiation and by achieving higher drug concentrations in living cells. Drug selectivity in targeting the affected cellular compartment is most important. Molecular design and synthesis of drugs should be based on high resolution structures and analysis of specific compounds and host molecules; however, it is necessary to obtain crystals for X-ray structural analysis. Because compounds containing bulky functional groups are difficult to crystalize due to their flexibility, the method described here makes it possible to stabilize these compounds by complexing them with protein molecules. We have first solved the three-dimensional structure of a BNCT drug-protein molecule combination at 1.26 Å resolution, and discuss the nature of the interaction between a BNCT drug and the protein molecule residues.  (日)    [継承]
キーワード (推奨): 1. (英) boron tracedrug (日) (読) [継承]
2. (英) boron neutron capture therapy (日) (読) [継承]
3. (英) protein structure (日) (読) [継承]
4. (英) X-ray crystal analysis (日) (読) [継承]
発行所 (推奨): Elsevier (->組織[Elsevier Science]) [継承]
誌名 (必須): Journal of Pharmaceutical Sciences (American Pharmaceutical Association/American Pharmacists Association/Fédération internationale pharmaceutique/American Association of Pharmaceutical Scientists)
(pISSN: 0022-3549, eISSN: 1520-6017)

ISSN (任意): 1520-6017
ISSN: 0022-3549 (pISSN: 0022-3549, eISSN: 1520-6017)
Title: Journal of pharmaceutical sciences
Title(ISO): J Pharm Sci
Publisher: Elsevier Inc.
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 105 [継承]
(必須): 8 [継承]
(必須): 2298 2301 [継承]
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年月日 (必須): 西暦 2016年 7月 13日 (平成 28年 7月 13日) [継承]
URL (任意):
DOI (任意): 10.1016/j.xphs.2016.06.005    (→Scopusで検索) [継承]
PMID (任意): 27422088    (→Scopusで検索) [継承]
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Scopus (任意): 2-s2.0-84978969925 [継承]
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備考 (任意): 1.(英) Article.ELocationID: 10.1016/j.xphs.2016.06.005  (日)    [継承]
2.(英) Article.ELocationID: S0022-3549(16)41500-5  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
4.(英) KeywordList.Keyword: X-ray crystal analysis  (日)    [継承]
5.(英) KeywordList.Keyword: boron neutron capture therapy  (日)    [継承]
6.(英) KeywordList.Keyword: boron tracedrug  (日)    [継承]
7.(英) KeywordList.Keyword: protein structure  (日)    [継承]

標準的な表示

和文冊子 ● Yukio Morimoto, Hideko Nagasawa, Yoshihiro Uto, Toshiyuki Chatake and Hitoshi Hori : Structural Insight Into Protein Binding of Boron Tracedrug UTX-97 Revealed by the Co-Crystal Structure With Lysozyme at 1.26 Å Resolution, Journal of Pharmaceutical Sciences, Vol.105, No.8, 2298-2301, 2016.
欧文冊子 ● Yukio Morimoto, Hideko Nagasawa, Yoshihiro Uto, Toshiyuki Chatake and Hitoshi Hori : Structural Insight Into Protein Binding of Boron Tracedrug UTX-97 Revealed by the Co-Crystal Structure With Lysozyme at 1.26 Å Resolution, Journal of Pharmaceutical Sciences, Vol.105, No.8, 2298-2301, 2016.

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