| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
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| ○著者 (必須): | 1. | 岡本 耕一 ([徳島大学.病院.診療科.内科.消化器内科])
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| 2. | 北村 晋志
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| 3. | 木村 哲夫
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| 4. | 中川 忠彦
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| 5. | 曽我部 正弘 ([徳島大学.キャンパスライフ健康支援センター])
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| 6. | 宮本 弘志 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.消化器内科学]/[徳島大学.病院.診療科.内科.消化器内科])
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| 7. | 六車 直樹
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| 8. | 高山 哲治 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.消化器内科学])
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| ○題名 (必須): | □ | (英) Clinicopathological Characteristics of Serrated Polyps as Precursors to Colorectal Cancer: Current Status and Management. (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Serrated polyps have long been thought to lack malignant potential in the human colorectum. However, identification of the serrated pathway to colorectal cancer based on molecular biology has improved our understanding of the pathogenesis of colorectal cancers. Accordingly, serrated polyps such as traditional serrated adenoma and sessile serrated adenoma/polyps (SSA/P) are now considered to be precursor lesions of the serrated pathway. Recently, serrated polyps were classified into three subtypes, consisting of hyperplastic polyp, SSA/P, and traditional serrated adenoma, according to the World Health Organization classification. It has been suggested that SSA/P in the proximal colon are a precursor lesion of pathogenesis of colorectal cancer and are characterized by BRAF mutation and a CpG island methylator phenotype with or without microsatellite instability. However, SSA/P is more challenging to detect by colonoscopy and is likely to account for some interval cancers, particularly in the proximal colon because it presents flat or sessile, isochroous appearance, and occasionally has a mucous cap. Furthermore, the possibility has been raised that pathologists misclassify SSA/P as hyperplastic polyp. It is important for gastroenterologists to recognize the endoscopic features of serrated polyps to facilitate their detection and removal and also to establish postpolypectomy surveillance guidelines. In this review, we discuss the recent classification of serrated polyps; the molecular characteristics of the serrated pathway; appropriate diagnostic methods using endoscopy, including a new image-enhanced endoscopic technique; and management of these lesions. (日)
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| ○キーワード (推奨): |
| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Journal of Gastroenterology and Hepatology ([Blackwell Publishing Ltd])
(pISSN: 0815-9319, eISSN: 1440-1746)
| ○ISSN (任意): | □ | 1440-1746
ISSN: 0815-9319
(pISSN: 0815-9319, eISSN: 1440-1746) Title: Journal of gastroenterology and hepatologyTitle(ISO): J Gastroenterol HepatolSupplier: Journal of Gastroenterology and Hepatology FoundationPublisher: Blackwell (NLM Catalog)
(Wiley)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 32
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| ○号 (必須): | □ | 2
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| ○頁 (必須): | □ | 358 367
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2017年 2月 初日 (平成 29年 2月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1111/jgh.13482 (→Scopusで検索)
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| ○PMID (任意): | □ | 27376251 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS (任意): | □ | 000395649200012
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| ○Scopus (任意): | □ | 2-s2.0-85013296238
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| ○評価値 (任意): |
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| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1111/jgh.13482 (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Review (日)
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| 4. | (英) KeywordList.Keyword: DNA methylation (日)
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| 5. | (英) KeywordList.Keyword: SSA/P (日)
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| 6. | (英) KeywordList.Keyword: Serrated polyps (日)
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| 7. | (英) KeywordList.Keyword: colorectal cancer (日)
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| 8. | (英) KeywordList.Keyword: serrated pathway (日)
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