| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○著者 (必須): | 1. | (英) Takeshi Kurihara (日) 栗原 健士 (読) くりはら たけし
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| ○学籍番号 (推奨): | □ | ****
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| 2. | 有持 秀喜 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.生体防御医学])
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| 3. | (英) Zaied Ahmed Bhuyan (日) Bhuyan Zaied Ahmed (読) ぶや ざいど あはまど
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| ○学籍番号 (推奨): | □ | ****
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| 4. | 石舟 智恵子 ([徳島大学.大学院医歯薬学研究部.医学域.先端医学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.生体防御医学])
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| 5. | (英) Hideki Tsumura (日) (読)
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| 6. | (英) Morihiro Ito (日) (読)
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| 7. | (英) Yasuhiko Ito (日) (読)
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| 8. | 北村 明子
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| 9. | 前川 洋一
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| 10. | 安友 康二 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.生体防御医学])
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| ○題名 (必須): | □ | (英) CD98 Heavy Chain Is a Potent Positive Regulator of CD4+ T Cell Proliferation and Interferon- Production In Vivo (日)
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| ○要約 (任意): | □ | (英) Upon their recognition of antigens presented by the MHC, T cell proliferation is vital for clonal expansion and the acquisition of effector functions, which are essential for mounting adaptive immune responses. The CD98 heavy chain (CD98hc, Slc3a2) plays a crucial role in the proliferation of both CD4+ and CD8+ T cells, although it is unclear if CD98hc directly regulates the T cell effector functions that are not linked with T cell proliferation in vivo. Here, we demonstrate that CD98hc is required for both CD4+ T cell proliferation and Th1 functional differentiation. T cell-specific deletion of CD98hc did not affect T cell development in the thymus. CD98hc-deficient CD4+ T cells proliferated in vivo more slowly as compared with control T cells. C57BL/6 mice lacking CD98hc in their CD4+ T cells could not control Leishmania major infections due to lowered IFN- production, even with massive CD4+ T cell proliferation. CD98hc-deficient CD4+ T cells exhibited lower IFN- production compared with wild-type T cells, even when comparing IFN- expression in cells that underwent the same number of cell divisions. Therefore, these data indicate that CD98hc is required for CD4+ T cell expansion and functional Th1 differentiation in vivo, and suggest that CD98hc might be a good target for treating Th1-mediated immune disorders. (日)
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| ○キーワード (推奨): |
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| ○誌名 (必須): | □ | PLoS ONE (Public Library of Science)
(eISSN: 1932-6203)
| ○ISSN (任意): | □ | 1932-6203
ISSN: 1932-6203
(eISSN: 1932-6203) Title: PloS oneTitle(ISO): PLoS OnePublisher: PLOS (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 10
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| ○号 (必須): | □ | 10
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| ○頁 (必須): | □ | e0139692 e0139692
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| ○年月日 (必須): | □ | 西暦 2015年 10月 7日 (平成 27年 10月 7日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1371/journal.pone.0139692 (→Scopusで検索)
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| ○PMID (任意): | □ | 26444422 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1371/journal.pone.0139692 (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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| 4. | (英) OtherID: PMC4596652 (日)
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