| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○著者 (必須): | 1. | 水口 博之
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| 2. | (英) Nariai Y (日) (読)
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| 3. | (英) Kato S (日) (読)
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| 4. | (英) Nakano T (日) (読)
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| 5. | (英) Kanayama T (日) (読)
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| 6. | 柏田 良樹
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| 7. | 根本 尚夫
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| 8. | 川添 和義
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| 9. | 高石 喜久
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| 10. | 北村 嘉章 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.耳鼻咽喉科・頭頸部外科学]/[徳島大学.病院.診療科.感覚·皮膚·運動機能科.耳鼻咽喉科・頭頸部外科])
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| 11. | 武田 憲昭
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| 12. | 福井 裕行
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| ○題名 (必須): | □ | (英) Maackiain is a novel antiallergic compound that suppresses transcriptional upregulation of the histamine H1 receptor and interleukin-4 genes. (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Kujin contains antiallergic compounds that inhibit upregulation of histamine H1 receptor (H1R) and interleukin (IL)-4 gene expression. However, the underlying mechanism remains unknown. We sought to identify a Kujin-derived antiallergic compound and investigate its mechanism of action. The H1R and IL-4 mRNA levels were determined by real-time quantitative RT-PCR. To investigate the effects of maackiain in vivo, toluene-2,4-diisocyanate (TDI)-sensitized rats were used as a nasal hypersensitivity animal model. We identified (-)-maackiain as the responsible component. Synthetic maackiain showed stereoselectivity for the suppression of IL-4 gene expression but not for H1R gene expression, suggesting distinct target proteins for transcriptional signaling. (-)-Maackiain inhibited of PKCδ translocation to the Golgi and phosphorylation of Tyr(311) on PKCδ, which led to the suppression of H1R gene transcription. However, (-)-maackiain did not show any antioxidant activity or inhibition of PKCδ enzymatic activity per se. Pretreatment with maackiain alleviated nasal symptoms and suppressed TDI-induced upregulations of H1R and IL-4 gene expressions in TDI-sensitized rats. These data suggest that (-)-maackiain is a novel antiallergic compound that alleviates nasal symptoms in TDI-sensitized allergy model rats through the inhibition of H1R and IL-4 gene expression. The molecular mechanism underlying its suppressive effect for H1R gene expression is mediated by the inhibition of PKCδ activation. (日)
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| ○キーワード (推奨): |
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| ○誌名 (必須): | □ | Pharmacology Research & Perspectives (British Pharmacological Society/American Society for Pharmacology and Experimental Therapeutics)
(eISSN: 2052-1707)
| ○ISSN (任意): | □ | 2052-1707
ISSN: 2052-1707
(eISSN: 2052-1707) Title: Pharmacology research & perspectivesTitle(ISO): Pharmacol Res PerspectPublisher: Wiley-Blackwell Publishing Ltd (NLM Catalog)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 3
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| ○号 (必須): | □ | 5
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| ○頁 (必須): | □ | e00166 e00166
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2015年 8月 10日 (平成 27年 8月 10日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1002/prp2.166 (→Scopusで検索)
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| ○PMID (任意): | □ | 26516579 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1002/prp2.166 (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) OtherID: PMC4618638 (日)
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| 4. | (英) KeywordList.Keyword: Allergic disease sensitive gene (日)
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| 5. | (英) KeywordList.Keyword: IL-4 gene (日)
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| 6. | (英) KeywordList.Keyword: Kujin (日)
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| 7. | (英) KeywordList.Keyword: PKC δ (日)
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| 8. | (英) KeywordList.Keyword: histamine H1 receptor gene (日)
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| 9. | (英) KeywordList.Keyword: maackiain (日)
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