| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): | □ | Peer Review
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| ○カテゴリ (推奨): | □ | 研究
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| ○共著種別 (推奨): | □ | 単独著作 (徳島大学内の単一の研究グループ(研究室等)内の研究 (単著も含む))
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| ○学究種別 (推奨): |
| ○組織 (推奨): | 1. | 徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.口腔顎顔面矯正学 (2015年4月1日〜)
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| ○著者 (必須): | 1. | 井澤 俊
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| 2. | 森 浩喜
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| 3. | 篠原 丈裕 ([徳島大学.口腔科学研究科.口腔科学専攻.口腔健康科学講座.口腔顎顔面矯正学])
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| 4. | 三野 彰子 ([徳島大学.口腔科学研究科.口腔科学専攻.口腔健康科学講座.口腔顎顔面矯正学])
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| 5. | (英) Hutami Rahma Islamy (日) ISLAMY RAHMA HUTAMI (読) いすらみ らふま ふたみ
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| ○学籍番号 (推奨): | □ | ****
| [ユーザ] |
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| 6. | 岩浅 亮彦
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| 7. | 田中 栄二 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.口腔顎顔面矯正学])
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| ○題名 (必須): | □ | (英) Rebamipide attenuates mandibular condylar degeneration in a murine model of TMJ-OA by mediating a chondroprotective effect and by downregulating RANKL-mediated osteoclastogenesis (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Temporomandibular joint osteoarthritis (TMJ-OA) is characterized by progressive degradation of cartilage and changes in subchondral bone. It is also one of the most serious subgroups of temporomandibular disorders. Rebamipide is a gastroprotective agent that is currently used for the treatment of gastritis and gastric ulcers. It scavenges reactive oxygen radicals and has exhibited anti-inflammatory potential. The aim of this study was to investigate the impact of rebamipide both in vivo and in vitro on the development of cartilage degeneration and osteoclast activity in an experimental murine model of TMJ-OA, and to explore its mode of action. Oral administration of rebamipide (0.6 mg/kg and 6 mg/kg) was initiated 24 h after TMJ-OA was induced, and was maintained daily for four weeks. Rebamipide treatment was found to attenuate cartilage degeneration, to reduce the number of apoptotic cells, and to decrease the expression levels of matrix metalloproteinase-13 (MMP-13) and inducible nitric oxide synthase (iNOS) in TMJ-OA cartilage in a dose-dependent manner. Rebamipide also suppressed the activation of transcription factors (e.g., NF-κB, NFATc1) and mitogen-activated protein kinases (MAPK) by receptor activator of nuclear factor kappa-B ligand (RANKL) to inhibit the differentiation of osteoclastic precursors, and disrupted the formation of actin rings in mature osteoclasts. Together, these results demonstrate the inhibitory effects of rebamipide on cartilage degradation in experimentally induced TMJ-OA. Furthermore, suppression of oxidative damage, restoration of extracellular matrix homeostasis of articular chondrocytes, and reduced subchondral bone loss as a result of blocked osteoclast activation suggest that rebamipide is a potential therapeutic strategy for TMJ-OA. (日)
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| ○キーワード (推奨): |
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| ○誌名 (必須): | □ | PLoS ONE (Public Library of Science)
(eISSN: 1932-6203)
| ○ISSN (任意): | □ | 1932-6203
ISSN: 1932-6203
(eISSN: 1932-6203) Title: PloS oneTitle(ISO): PLoS OnePublisher: PLOS (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 11
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| ○号 (必須): | □ | 4
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| ○頁 (必須): | □ | e0154107 e0154107
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2016年 4月 28日 (平成 28年 4月 28日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1371/journal.pone.0154107 (→Scopusで検索)
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| ○PMID (任意): | □ | 27123995 (→Scopusで検索)
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| ○機関リポジトリ : | □ | 112307
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| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1371/journal.pone.0154107 (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) OtherID: PMC4849711 (日)
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