『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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カテゴリ (推奨):
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組織 (推奨):
著者 (必須): 1. (英) Matsushita Shoko (日) (読)
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[継承]
2. (英) Suzuki Kentaro (日) (読)
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[継承]
3. (英) Ogino Yukiko (日) (読)
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4. (英) Hino Shinjiro (日) (読)
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5. (英) Sato Tetsuya (日) (読)
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6. (英) Suyama Mikita (日) (読)
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7.松本 高広 ([徳島大学.先端研究推進センター.動物資源研究部門]/[徳島大学.大学院医歯薬学研究部.医学域.総合研究支援センター.動物資源研究部門])
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8. (英) Omori Akiko (日) (読)
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9. (英) Inoue Satoshi (日) (読)
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10. (英) Yamada Gen (日) (読)
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題名 (必須): (英) Androgen Regulates Mafb Expression Through its 3'UTR During Mouse Urethral Masculinization.  (日)    [継承]
副題 (任意):
要約 (任意): (英) External genitalia are prominent organs showing hormone-dependent sexual differentiation. Androgen is an essential regulator of masculinization of the genital tubercle, which is the anlage of external genitalia. We have previously shown that v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B (MAFB) is an androgen-inducible regulator of embryonic urethral masculinization in mice. However, it remains unclear how androgen regulates Mafb expression. The current study suggests that the Mafb 3' untranslated region (UTR) is an essential region for its regulation by androgen. We identified 2 functional androgen response elements (AREs) in Mafb 3'UTR. Androgen receptor is bound to such AREs in 3'UTR during urethral masculinization. In addition to 3'UTR, Mafb 5'UTR also showed androgen responsiveness. Moreover, we also demonstrated that -catenin, one of genital tubercle masculinization factors, may be an additional regulator of Mafb expression during urethral masculinization. This study provides insights to elucidate mechanisms of gene regulation through AREs present in Mafb 3'UTR for a better understanding of the processes of urethral masculinization.  (日)    [継承]
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誌名 (必須): Endocrinology ([The Endocrine Society])
(pISSN: 0013-7227, eISSN: 1945-7170)

ISSN (任意): 1945-7170
ISSN: 0013-7227 (pISSN: 0013-7227, eISSN: 1945-7170)
Title: Endocrinology
Title(ISO): Endocrinology
Publisher: Endocrine Society
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 157 [継承]
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(必須): 844 857 [継承]
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年月日 (必須): 西暦 2015年 12月 4日 (平成 27年 12月 4日) [継承]
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DOI (任意): 10.1210/en.2015-1586    (→Scopusで検索) [継承]
PMID (任意): 26636186    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Shoko Matsushita, Kentaro Suzuki, Yukiko Ogino, Shinjiro Hino, Tetsuya Sato, Mikita Suyama, Takahiro Matsumoto, Akiko Omori, Satoshi Inoue and Gen Yamada : Androgen Regulates Mafb Expression Through its 3'UTR During Mouse Urethral Masculinization., Endocrinology, Vol.157, No.2, 844-857, 2015.
欧文冊子 ● Shoko Matsushita, Kentaro Suzuki, Yukiko Ogino, Shinjiro Hino, Tetsuya Sato, Mikita Suyama, Takahiro Matsumoto, Akiko Omori, Satoshi Inoue and Gen Yamada : Androgen Regulates Mafb Expression Through its 3'UTR During Mouse Urethral Masculinization., Endocrinology, Vol.157, No.2, 844-857, 2015.

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