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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Fukushima Y (日) (読)
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学籍番号 (推奨):
[継承]
2. (英) Asano T (日) (読)
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[継承]
3. (英) Katagiri H (日) (読)
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[継承]
4. (英) Aihara M (日) (読)
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[継承]
5. (英) Saitoh T (日) (読)
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学籍番号 (推奨):
[継承]
6. (英) Anai M (日) (読)
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学籍番号 (推奨):
[継承]
7.船木 真理 ([徳島大学.病院.中央診療施設等.糖尿病対策センター])
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学籍番号 (推奨):
[継承]
8. (英) Ogihara T (日) (読)
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学籍番号 (推奨):
[継承]
9. (英) Inukai K (日) (読)
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学籍番号 (推奨):
[継承]
10. (英) Matsuhashi N (日) (読)
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学籍番号 (推奨):
[継承]
11. (英) Oka Y (日) (読)
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[継承]
12. (英) Yazaki Y (日) (読)
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[継承]
13. (英) Sugano K (日) (読)
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[継承]
題名 (必須): (英) Interaction between the two signal transduction systems of the histamine H2 receptor: desensitizing and sensitizing effects of histamine stimulation on histamine-dependent cAMP production in Chinese hamster ovary cells.  (日)    [継承]
副題 (任意):
要約 (任意): (英) The histamine H2 receptor is a member of the family of G-protein-coupled receptors and is linked to the activation of adenylate cyclase phospholipase C (PLC). In this study we examined the effects of protein kinase C (PKC) activation in Chinese hamster ovary (CHO) cells stably expressing canine histamine H2 receptors. Pretreatment with 100 nM phorbol 12-myristate 13-acetate at 37 degrees C for 15 min led to significant potentiation of histamine-dependent and forskolin-dependent cAMP production, whereas the biologically inactive phorbol ester, 4 alpha-phorbol 12, 13-didecanoate, was without effect. These potentiating effects were abolished by preincubation with 0.5 microM bisindolylmaleimide, a PKC inhibitor. Thus the activation of PKCs seems to be involved in the potentiation of cAMP production by acting on a post-receptor mechanism. Preincubation of a CHO cell line, CHO-H2R, with 10 microM histamine for 30 min had two effects. Maximal histamine-dependent cAMP production and forskolin-dependent cAMP production were potentiated by 36% and 105.2% respectively. The other effect was a desensitization of the histamine-dependent adenylate cyclase response as demonstrated by a three-fold increase in EC50. Administration of 0.5 microM bisindolylmaleimide before preincubation of CHO-H2R with 10 microM histamine did not alter the desensitizing effect on cAMP production, but did abolish the sensitizing effect. Preincubation of CHO-H2R cells with 10 nM histamine resulted in moderate potentiation, which was also abolished by bisindolylmaleimide, but not in desensitization of the histamine-dependent cAMP production. Thus these results suggest that preincubation with histamine had a sensitizing effect on cAMP production mediated by PLC and PKC activation, as well as a desensitizing effect on the H2 receptor. The former effect is dependent on the intensity of PLC and PKC signals delivered by H2 receptors. The latter effect requires a higher concentration of histamine.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) CHO Cells (日) (読) [継承]
3. (英) Colforsin (日) (読) [継承]
4. (英) Cricetinae (日) (読) [継承]
5. (英) Cricetulus (日) (読) [継承]
6. (英) Cyclic AMP (日) (読) [継承]
7. (英) Dogs (日) (読) [継承]
8.ヒスタミン (histamine) [継承]
9. (英) Histamine Agonists (日) (読) [継承]
10. (英) Indoles (日) (読) [継承]
11. (英) Maleimides (日) (読) [継承]
12. (英) Receptors, Histamine H2 (日) (読) [継承]
13. (英) Recombinant Proteins (日) (読) [継承]
14.シグナル伝達 (signal transduction) [継承]
15. (英) Tetradecanoylphorbol Acetate (日) (読) [継承]
発行所 (推奨):
誌名 (必須): The Biochemical Journal ([The Biochemical Society])
(pISSN: 0264-6021, eISSN: 1470-8728)

ISSN (任意): 0264-6021
ISSN: 0264-6021 (pISSN: 0264-6021, eISSN: 1470-8728)
Title: The Biochemical journal
Title(ISO): Biochem J
Publisher: Portland Press, Ltd.
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 320 ( Pt 1) [継承]
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(必須): 27 32 [継承]
都市 (任意):
年月日 (必須): 西暦 1996年 11月 15日 (平成 8年 11月 15日) [継承]
URL (任意):
DOI (任意): 10.1042/bj3200027    (→Scopusで検索) [継承]
PMID (任意): 8947463    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) PublicationType: Journal Article  (日)    [継承]
2.(英) PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Y Fukushima, T Asano, H Katagiri, M Aihara, T Saitoh, M Anai, Makoto Funaki, T Ogihara, K Inukai, N Matsuhashi, Y Oka, Y Yazaki and K Sugano : Interaction between the two signal transduction systems of the histamine H2 receptor: desensitizing and sensitizing effects of histamine stimulation on histamine-dependent cAMP production in Chinese hamster ovary cells., The Biochemical Journal, Vol.320 ( Pt 1), (号), 27-32, 1996.
欧文冊子 ● Y Fukushima, T Asano, H Katagiri, M Aihara, T Saitoh, M Anai, Makoto Funaki, T Ogihara, K Inukai, N Matsuhashi, Y Oka, Y Yazaki and K Sugano : Interaction between the two signal transduction systems of the histamine H2 receptor: desensitizing and sensitizing effects of histamine stimulation on histamine-dependent cAMP production in Chinese hamster ovary cells., The Biochemical Journal, Vol.320 ( Pt 1), (号), 27-32, 1996.

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