『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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○種別 (必須): □学術論文 (審査論文) [継承]
○言語 (必須): □英語 [継承]
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○著者 (必須): 1. (英) Yeung Tony (日) (読)
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2. (英) Georges Penelope C (日) (読)
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3. (英) Flanagan Lisa A (日) (読)
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4. (英) Marg Beatrice (日) (読)
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5. (英) Ortiz Miguelina (日) (読)
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6.船木 真理
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7. (英) Zahir Nastaran (日) (読)
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8. (英) Ming Wenyu (日) (読)
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9. (英) Weaver Valerie (日) (読)
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10. (英) Janmey Paul A (日) (読)
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○題名 (必須): □(英) Effects of substrate stiffness on cell morphology, cytoskeletal structure, and adhesion.  (日)    [継承]
○副題 (任意):
○要約 (任意): □(英) The morphology and cytoskeletal structure of fibroblasts, endothelial cells, and neutrophils are documented for cells cultured on surfaces with stiffness ranging from 2 to 55,000 Pa that have been laminated with fibronectin or collagen as adhesive ligand. When grown in sparse culture with no cell-cell contacts, fibroblasts and endothelial cells show an abrupt change in spread area that occurs at a stiffness range around 3,000 Pa. No actin stress fibers are seen in fibroblasts on soft surfaces, and the appearance of stress fibers is abrupt and complete at a stiffness range coincident with that at which they spread. Upregulation of alpha5 integrin also occurs in the same stiffness range, but exogenous expression of alpha5 integrin is not sufficient to cause cell spreading on soft surfaces. Neutrophils, in contrast, show no dependence of either resting shape or ability to spread after activation when cultured on surfaces as soft as 2 Pa compared to glass. The shape and cytoskeletal differences evident in single cells on soft compared to hard substrates are eliminated when fibroblasts or endothelial cells make cell-cell contact. These results support the hypothesis that mechanical factors impact different cell types in fundamentally different ways, and can trigger specific changes similar to those stimulated by soluble ligands.  (日)    [継承]
○キーワード (推奨): 1. (英) Actins (日) (読) [継承]
2. (英) Animals (日) (読) [継承]
3. (英) Aorta (日) (読) [継承]
4. (英) Cattle (日) (読) [継承]
5. (英) Cell Adhesion (日) (読) [継承]
6. (英) Cell Line (日) (読) [継承]
7. (英) Cells, Cultured (日) (読) [継承]
8.コラーゲン (collagen) [継承]
9. (英) Cytoskeleton (日) (読) [継承]
10. (英) Endothelium, Vascular (日) (読) [継承]
11.細胞外マトリックス (extracellular matrix) [継承]
12. (英) Fibroblasts (日) (読) [継承]
13. (英) Fibronectins (日) (読) [継承]
14. (英) Glass (日) (読) [継承]
15. (英) Green Fluorescent Proteins (日) (読) [継承]
16. (英) Humans (日) (読) [継承]
17. (英) Integrin alpha5 (日) (読) [継承]
18. (英) Mice (日) (読) [継承]
19. (英) Microscopy, Confocal (日) (読) [継承]
20. (英) NIH 3T3 Cells (日) (読) [継承]
21. (英) Neutrophils (日) (読) [継承]
22. (英) Stress Fibers (日) (読) [継承]
23.界面特性 (surface properties) [継承]
○発行所 (推奨):
○誌名 (必須): □Cell Motility and the Cytoskeleton ([Wiley-Liss, Inc.])
(pISSN: 0886-1544, eISSN: 1097-0169)

○ISSN (任意): □0886-1544
ISSN: 0886-1544 (pISSN: 0886-1544, eISSN: 1097-0169)
Title: Cell motility and the cytoskeleton
Title(ISO): Cell Motil Cytoskeleton
Publisher: Wiley
 (NLM Catalog)   (Scopus)   (CrossRef)  (Scopus information is found. [need login])
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○巻 (必須): □60 [継承]
○号 (必須): □1 [継承]
○頁 (必須): □24 34 [継承]
○都市 (任意):
○年月日 (必須): □西暦 2005年 1月 初日 (平成 17年 1月 初日) [継承]
○URL (任意):
○DOI (任意): □10.1002/cm.20041    (→Scopusで検索) [継承]
○PMID (任意): □15573414    (→Scopusで検索) [継承]
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○備考 (任意): 1.(英) PublicationType: Comparative Study  (日)    [継承]
2.(英) PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Tony Yeung, C Penelope Georges, A Lisa Flanagan, Beatrice Marg, Miguelina Ortiz, Makoto Funaki, Nastaran Zahir, Wenyu Ming, Valerie Weaver and A Paul Janmey : Effects of substrate stiffness on cell morphology, cytoskeletal structure, and adhesion., Cell Motility and the Cytoskeleton, Vol.60, No.1, 24-34, 2005.
欧文冊子 ● Tony Yeung, C Penelope Georges, A Lisa Flanagan, Beatrice Marg, Miguelina Ortiz, Makoto Funaki, Nastaran Zahir, Wenyu Ming, Valerie Weaver and A Paul Janmey : Effects of substrate stiffness on cell morphology, cytoskeletal structure, and adhesion., Cell Motility and the Cytoskeleton, Vol.60, No.1, 24-34, 2005.

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