| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Umeno Aya (日) (読)
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| 2. | (英) Shichiri Mototada (日) (読)
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| 3. | (英) Ishida Noriko (日) (読)
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| 4. | (英) Hashimoto Yoshiko (日) (読)
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| 5. | 阿部 佳織
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| 6. | 片岡 正俊
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| 7. | (英) Yoshino Kohzoh (日) (読)
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| 8. | (英) Hagihara Yoshihisa (日) (読)
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| 9. | (英) Aki Nanako (日) (読)
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| 10. | 船木 真理
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| 11. | (英) Asada Yasuhiko (日) (読)
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| 12. | (英) Yoshida Yasukazu (日) (読)
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| ○題名 (必須): | □ | (英) Singlet oxygen induced products of linoleates, 10- and 12-(Z,E)-hydroxyoctadecadienoic acids (HODE), can be potential biomarkers for early detection of type 2 diabetes. (日)
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| ○要約 (任意): | □ | (英) (日) Current diagnostic tests such as glycemic indicators have limitations for early detection of impaired glucose tolerance (IGT), which leads to diabetes. Oxidative stress induced by various oxidants in a random and destructive manner is considered to play an important role in the pathophysiology of a number of human disorders and diseases such as impaired glucose tolerance. We have developed an improved method for the measurement of in vivo lipid peroxidation, where the presence of 8-iso-prostaglandin F2α (8-iso-PGF2α), hydroxyoctadecadienoic acids (HODEs), hydroxyeicosatetraenoic acids (HETEs), and 7-hydroxycholesterol (7-OHCh), as well as their parent molecules, linoleic acid (LA) and cholesterol (Ch), was determined by performing LC-MS/MS (for 8-iso-PGF2α, HODE, and HETE) and GC-MS (for 7-OHCh, LA, and Ch) after reduction with triphenyl phosphine and saponification by potassium hydroxide. We then applied this method to volunteers (n = 57), including normal type (n = 43), "high-normal" (fasting plasma glucose, 100-109 mg/dL, n = 7), pre-diabetic type (IGT, n = 5), and diabetic type (n = 2) subjects who are diagnosed by performing oral glucose tolerance tests (OGTTs). Several biomarkers in plasma, such as insulin, leptin, adiponectin, interleukin-6, tumor necrosis factor-α, high sensitivity-C-reactive protein, HbA1c, and glucose levels were measured during OGTT. We found that the fasting levels of (10- and 12-(Z,E)- HODE)/LA increased significantly with increasing levels of HbA1c and glucose during OGTT and with insulin secretion and resistance index. In conclusion, 10- and 12-(Z,E)-HODE may be prominent biomarkers for the early detection of IGT and "high-normal" type without OGTT.
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| ○キーワード (推奨): | 1. | (英) Adipokines (日) (読)
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| 2. | (英) Adult (日) (読)
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| 3. | (英) Biomarkers (日) (読)
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| 4. | (英) Diabetes Mellitus, Type 2 (日) (読)
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| 5. | (英) Early Diagnosis (日) (読)
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| 6. | (英) Fatty Acids, Unsaturated (日) (読)
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| 7. | (英) Female (日) (読)
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| 8. | (英) Gas Chromatography-Mass Spectrometry (日) (読)
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| 9. | (英) Glucose Tolerance Test (日) (読)
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| 10. | (英) Humans (日) (読)
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| 11. | (英) Linoleic Acids (日) (読)
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| 12. | (英) Male (日) (読)
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| 13. | (英) Middle Aged (日) (読)
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| 14. | 酸化ストレス (oxidative stress)
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| 15. | (英) Singlet Oxygen (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | PLoS ONE (Public Library of Science)
(eISSN: 1932-6203)
| ○ISSN (任意): | □ | 1932-6203
ISSN: 1932-6203
(eISSN: 1932-6203) Title: PloS oneTitle(ISO): PLoS OnePublisher: PLOS (NLM Catalog)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 8
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| ○号 (必須): | □ | 5
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| ○頁 (必須): | □ | e63542 e63542
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2013年 5月 15日 (平成 25年 5月 15日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1371/journal.pone.0063542 (→Scopusで検索)
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| ○PMID (任意): | □ | 23691063 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) PublicationType: Journal Article (日)
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| 2. | (英) PublicationType: Research Support, Non-U.S. Gov't (日)
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