『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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登録内容 (EID=308366)

EID=308366EID:308366, Map:0, LastModified:2016年4月18日(月) 14:55:00, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[岡村 裕彦], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨): 国際共著 (徳島大学内研究者と国外研究機関所属研究者との共同研究) [継承]
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1.楊 諦
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学籍番号 (推奨):
[継承]
2.岡村 裕彦
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学籍番号 (推奨):
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3.寺町 順平
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4.羽地 達次
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学籍番号 (推奨):
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題名 (必須): (英) Histone demethylase Jmjd3 regulates osteoblast apoptosis through targeting anti-apoptotic protein Bcl-2 and pro-apoptotic protein Bim.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Posttranslational modifications including histone methylation regulate gene transcription through directly affecting the structure of chromatin. Trimethylation of histone H3K27 (H3K27me3) contributes to gene silencing and the histone demethylase Jumonji domain-containing 3 (Jmjd3) specifically removes the methylation of H3K27me3, followed by the activation of gene expression. In the present study, we explored the roles of Jmjd3 in regulating osteoblast apoptosis. Knockdown of Jmjd3 promoted osteoblast apoptosis induced by serum deprivation with decreased mitochondrial membrane potential and increased levels of caspase-3 activation, PARP cleavage, and DNA fragmentation. B cell lymphoma-2 (Bcl-2), an anti-apoptotic protein, was down-regulated by knockdown of Jmjd3 through retaining H3K27me3 on its promoter region. Knockdown of Jmjd3 increased the pro-apoptotic activity of Bim through inhibiting ERK-dependent phosphorylation of Bim. Protein kinase D1 (PKD1), which stimulates ERK phosphorylation, decreased in the Jmjd3-knockdown cells and introduction of PKD1 relieved osteoblast apoptosis in the Jmjd3-knockdown cells through increasing ERK-regulated Bim phosphorylation. These results suggest that Jmjd3 regulates osteoblast apoptosis through targeting Bcl-2 expression and Bim phosphorylation.  (日)    [継承]
キーワード (推奨): 1.骨芽細胞 (osteoblast) [継承]
発行所 (推奨):
誌名 (必須): Biochimica et Biophysica Acta (BBA) - Molecular Cell Research ([Elsevier Science])
(pISSN: 0167-4889)

ISSN (任意): 0167-4889
ISSN: 0167-4889 (pISSN: 0167-4889, eISSN: 1879-2596)
Title: Biochimica et biophysica acta. Molecular cell research
Title(ISO): Biochim Biophys Acta Mol Cell Res
Publisher: Elsevier BV
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 1863 [継承]
(必須): 4 [継承]
(必須): 650 659 [継承]
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年月日 (必須): 西暦 2016年 1月 12日 (平成 28年 1月 12日) [継承]
URL (任意):
DOI (任意): 10.1016/j.bbamcr.2016.01.006    (→Scopusで検索) [継承]
PMID (任意): 26795455    (→Scopusで検索) [継承]
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WOS (任意): 000371940500014 [継承]
Scopus (任意): 2-s2.0-84956688215 [継承]
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備考 (任意): 1.(英) Article.ELocationID: 10.1016/j.bbamcr.2016.01.006  (日)    [継承]
2.(英) Article.ELocationID: S0167-4889(16)00009-4  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
4.(英) KeywordList.Keyword: Bcl-2  (日)    [継承]
5.(英) KeywordList.Keyword: Bim  (日)    [継承]
6.(英) KeywordList.Keyword: Histone demethylation  (日)    [継承]
7.(英) KeywordList.Keyword: Jmjd3  (日)    [継承]
8.(英) KeywordList.Keyword: Osteoblast apoptosis  (日)    [継承]
9.(英) KeywordList.Keyword: Protein kinase D1  (日)    [継承]

標準的な表示

和文冊子 ● Di Yang, Hirohiko Okamura, Jumpei Teramachi and Tatsuji Haneji : Histone demethylase Jmjd3 regulates osteoblast apoptosis through targeting anti-apoptotic protein Bcl-2 and pro-apoptotic protein Bim., Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Vol.1863, No.4, 650-659, 2016.
欧文冊子 ● Di Yang, Hirohiko Okamura, Jumpei Teramachi and Tatsuji Haneji : Histone demethylase Jmjd3 regulates osteoblast apoptosis through targeting anti-apoptotic protein Bcl-2 and pro-apoptotic protein Bim., Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Vol.1863, No.4, 650-659, 2016.

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