『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
ID: Pass:

登録内容 (EID=308365)

EID=308365EID:308365, Map:0, LastModified:2016年4月18日(月) 14:43:17, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[岡村 裕彦], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1.楊 諦
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2.岡村 裕彦
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
3.寺町 順平
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
4.羽地 達次
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Histone demethylase Utx regulates differentiation and mineralization in osteoblasts.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Alteration of methylation status of lysine 27 on histone H3 (H3K27) associates with dramatic changes in gene expression in response to various differentiation signals. Demethylation of H3K27 is controlled by specific histone demethylases including ubiquitously transcribed tetratricopeptide repeat X chromosome (Utx). However, the role of Utx in osteoblast differentiation remains unknown. In this study, we examined whether Utx should be involved in osteoblast differentiation. Expression of Utx increased during osteoblast differentiation in MC3T3-E1 cells and primary osteoblasts. GSK-J1, a potent inhibitor of H3K27 demethylase, increased the levels of trimethylated H3K27 (H3K27me3) and decreased the expressions of Runx2 and Osterix and ALP activity in MC3T3-E1 cells. Stable knockdown of Utx by shRNA attenuated osteoblast differentiation and decreased ALP activity, calcium content, and bone-related gene expressions. Silencing of Utx increased the level of H3K27me3 on the promoter regions of Runx2 and Osterix and decreased the promoter activities of Runx2 and Osterix. Taken together, our present results propose that Utx plays important roles in osteoblast differentiation by controlling the expressions of Runx2 and Osterix.  (日)    [継承]
キーワード (推奨): 1.骨芽細胞 (osteoblast) [継承]
発行所 (推奨):
誌名 (必須): Journal of Cellular Biochemistry ([Wiley-Liss, Inc.])
(pISSN: 0730-2312, eISSN: 1097-4644)

ISSN (任意): 1097-4644
ISSN: 0730-2312 (pISSN: 0730-2312, eISSN: 1097-4644)
Title: Journal of cellular biochemistry
Title(ISO): J Cell Biochem
Publisher: Wiley
 (NLM Catalog  (Wiley  (Scopus  (CrossRef (Scopus information is found. [need login])
[継承]
[継承]
(必須): 116 [継承]
(必須): 11 [継承]
(必須): 2628 2636 [継承]
都市 (任意):
年月日 (必須): 西暦 2015年 11月 初日 (平成 27年 11月 初日) [継承]
URL (任意):
DOI (任意): 10.1002/jcb.25210    (→Scopusで検索) [継承]
PMID (任意): 25920016    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意): 000361236800021 [継承]
Scopus (任意): 2-s2.0-84941105888 [継承]
評価値 (任意):
被引用数 (任意):
指導教員 (推奨):
備考 (任意): 1.(英) Article.ELocationID: 10.1002/jcb.25210  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]
4.(英) KeywordList.Keyword: H3K27ME3  (日)    [継承]
5.(英) KeywordList.Keyword: HISTONE DEMETHYLATION  (日)    [継承]
6.(英) KeywordList.Keyword: OSTEOBLAST DIFFERENTIATION  (日)    [継承]
7.(英) KeywordList.Keyword: OSTERIX  (日)    [継承]
8.(英) KeywordList.Keyword: RUNX2  (日)    [継承]
9.(英) KeywordList.Keyword: Utx  (日)    [継承]

標準的な表示

和文冊子 ● Di Yang, Hirohiko Okamura, Jumpei Teramachi and Tatsuji Haneji : Histone demethylase Utx regulates differentiation and mineralization in osteoblasts., Journal of Cellular Biochemistry, Vol.116, No.11, 2628-2636, 2015.
欧文冊子 ● Di Yang, Hirohiko Okamura, Jumpei Teramachi and Tatsuji Haneji : Histone demethylase Utx regulates differentiation and mineralization in osteoblasts., Journal of Cellular Biochemistry, Vol.116, No.11, 2628-2636, 2015.

関連情報

Number of session users = 1, LA = 0.54, Max(EID) = 376494, Max(EOID) = 1008315.