『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=308325EID:308325, Map:0, LastModified:2016年2月24日(水) 19:21:43, Operator:[馬場 麻人], Avail:TRUE, Censor:0, Owner:[馬場 麻人], Read:継承, Write:継承, Delete:継承.
種別 (必須):
言語 (必須): 英語 [継承]
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カテゴリ (推奨):
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学究種別 (推奨):
組織 (推奨):
著者 (必須): 1.馬場 麻人 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔顎顔面形態学])
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学籍番号 (推奨):
[継承]
2. (英) Qin Chunlin (日) (読)
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学籍番号 (推奨):
[継承]
3. (英) Brunn Jan C (日) (読)
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学籍番号 (推奨):
[継承]
4. (英) Wygant James N (日) (読)
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学籍番号 (推奨):
[継承]
5. (英) McIntyre Bradley W (日) (読)
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学籍番号 (推奨):
[継承]
6. (英) Butler William T (日) (読)
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学籍番号 (推奨):
[継承]
題名 (必須): (英) Colocalization of dentin matrix protein 1 and dentin sialoprotein at late stages of rat molar development.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Dentin matrix protein 1 (DMP1) and dentin sialophosphoprotein (DSPP) are acidic proteins found in the extracellular matrices of bones and teeth. Recent data from gene knockouts, along with those of gene mutations, indicate that these two phosphoproteins are critical for bone and tooth development and/or maintenance. However, the precise functions of the two proteins have not been elucidated. In order to gain insights into their functions in tooth formation, we performed systematic, comparative investigations on the immunolocalization of DMP1 and dentin sialoprotein (DSP, a cleaved fragment of DSPP), using the rat first molar at different developmental stages as a model. Immunohistochemistry (IHC) was performed with specific, monoclonal antibodies against the COOH-terminal fragments of DMP1 and against DSP. In 1-day- and 1-week-old rats, weak immunoreactions for DMP1 were observed in dentinal tubules while stronger reactions for DSP were seen in the tubules and predentin. In rats older than 2 weeks, immunoreactions for DMP1 were found in dentinal tubules, predentin and odontoblasts. In 5-week- and 8-week-old rats, strong immunoreactions for DMP1 were widely distributed in odontoblasts and predentin. The distribution pattern of DSP was strikingly similar to that of DMP1 after 2 weeks and the localization of each was distinctly different from that of bone sialoprotein (BSP). The unique colocalization of DMP1 and DSPP in tooth development suggests that the two proteins play complementary and/or synergistic roles in formation and maintenance of healthy teeth.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Antibodies, Monoclonal (日) (読) [継承]
3. (英) Bone and Bones (日) (読) [継承]
4. (英) Extracellular Matrix Proteins (日) (読) [継承]
5. (英) Gene Expression Regulation, Developmental (日) (読) [継承]
6.免疫組織化学 (immunohistochemistry) [継承]
7. (英) In Situ Hybridization (日) (読) [継承]
8. (英) Integrin-Binding Sialoprotein (日) (読) [継承]
9. (英) Molar (日) (読) [継承]
10. (英) Odontoblasts (日) (読) [継承]
11. (英) Phosphoproteins (日) (読) [継承]
12. (英) Protein Precursors (日) (読) [継承]
13. (英) Protein Structure, Tertiary (日) (読) [継承]
14. (英) Rats (日) (読) [継承]
15. (英) Rats, Sprague-Dawley (日) (読) [継承]
16. (英) Sialoglycoproteins (日) (読) [継承]
17. (英) Time Factors (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Matrix Biology (International Society for Matrix Biology)
(pISSN: 0945-053X, eISSN: 1569-1802)

ISSN (任意): 0945-053X
ISSN: 0945-053X (pISSN: 0945-053X, eISSN: 1569-1802)
Title: Matrix biology : journal of the International Society for Matrix Biology
Title(ISO): Matrix Biol
Publisher: Elsevier BV
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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都市 (任意):
年月日 (必須): 西暦 2004年 10月 初日 (平成 16年 10月 初日) [継承]
URL (任意):
DOI (任意): 10.1016/j.matbio.2004.07.008    (→Scopusで検索) [継承]
PMID (任意): 15533758    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) PublicationType: Journal Article  (日)    [継承]
2.(英) PublicationType: Research Support, U.S. Gov't, P.H.S.  (日)    [継承]

標準的な表示

和文冊子 ● (種別) : Otto Baba, Chunlin Qin, C Jan Brunn, N James Wygant, W Bradley McIntyre and T William Butler : Colocalization of dentin matrix protein 1 and dentin sialoprotein at late stages of rat molar development., Matrix Biology, Vol.23, No.6, 371-379, (発行所), (都市), Oct. 2004.
欧文冊子 ● (種別) : Otto Baba, Chunlin Qin, C Jan Brunn, N James Wygant, W Bradley McIntyre and T William Butler : Colocalization of dentin matrix protein 1 and dentin sialoprotein at late stages of rat molar development., Matrix Biology, Vol.23, No.6, 371-379, (発行所), (都市), Oct. 2004.

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