『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須):
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Geurtsen Jeroen (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2. (英) Chedammi Sunita (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
3. (英) Mesters Joram (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
4. (英) Cot Marlène (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
5. (英) Driessen Nicole N (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
6. (英) Sambou Tounkang (日) (読)
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学籍番号 (推奨):
[継承]
7. (英) Kakutani Ryo (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
8. (英) Ummels Roy (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
9. (英) Maaskant Janneke (日) (読)
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学籍番号 (推奨):
[継承]
10. (英) Takata Hiroki (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
11.馬場 麻人 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔顎顔面形態学])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
12. (英) Terashima Tatsuo (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
13. (英) Bovin Nicolai (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
14. (英) Vandenbroucke-Grauls Christina M J E (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
15. (英) Nigou Jérôme (日) (読)
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学籍番号 (推奨):
[継承]
16. (英) Puzo Germain (日) (読)
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学籍番号 (推奨):
[継承]
17. (英) Lemassu Anne (日) (読)
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学籍番号 (推奨):
[継承]
18. (英) Daffé Mamadou (日) (読)
役割 (任意):
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学籍番号 (推奨):
[継承]
19. (英) Appelmelk Ben J (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Identification of mycobacterial alpha-glucan as a novel ligand for DC-SIGN: involvement of mycobacterial capsular polysaccharides in host immune modulation.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Mycobacterium tuberculosis possesses a variety of immunomodulatory factors that influence the host immune response. When the bacillus encounters its target cell, the outermost components of its cell envelope are the first to interact. Mycobacteria, including M. tuberculosis, are surrounded by a loosely attached capsule that is mainly composed of proteins and polysaccharides. Although the chemical composition of the capsule is relatively well studied, its biological function is only poorly understood. The aim of this study was to further assess the functional role of the mycobacterial capsule by identifying host receptors that recognize its constituents. We focused on alpha-glucan, which is the dominant capsular polysaccharide. Here we demonstrate that M. tuberculosis alpha-glucan is a novel ligand for the C-type lectin DC-SIGN (dendritic cell-specific ICAM-3-grabbing nonintegrin). By using related glycogen structures, we show that recognition of alpha-glucans by DC-SIGN is a general feature and that the interaction is mediated by internal glucosyl residues. As for mannose-capped lipoarabinomannan, an abundant mycobacterial cell wall-associated glycolipid, binding of alpha-glucan to DC-SIGN stimulated the production of immunosuppressive IL-10 by LPS-activated monocyte-derived dendritic cells. By using specific inhibitors, we show that this IL-10 induction was DC-SIGN-dependent and also required acetylation of NF-kappaB. Finally, we demonstrate that purified M. tuberculosis alpha-glucan, in contrast to what has been reported for fungal alpha-glucan, was unable to activate TLR2.  (日)    [継承]
キーワード (推奨): 1. (英) Bacterial Capsules (日) (読) [継承]
2. (英) Cell Adhesion Molecules (日) (読) [継承]
3. (英) Cells, Cultured (日) (読) [継承]
4. (英) Dendritic Cells (日) (読) [継承]
5. (英) Glucans (日) (読) [継承]
6. (英) Humans (日) (読) [継承]
7. (英) Interleukin-10 (日) (読) [継承]
8. (英) Lectins, C-Type (日) (読) [継承]
9. (英) Lipopolysaccharides (日) (読) [継承]
10. (英) Mycobacterium tuberculosis (日) (読) [継承]
11. (英) NF-kappa B (日) (読) [継承]
12. (英) Receptors, Cell Surface (日) (読) [継承]
13. (英) Toll-Like Receptor 2 (日) (読) [継承]
発行所 (推奨):
誌名 (必須): The Journal of Immunology ([The American Association of Immunologists])
(pISSN: 0022-1767, eISSN: 1550-6606)

ISSN (任意): 1550-6606
ISSN: 0022-1767 (pISSN: 0022-1767, eISSN: 1550-6606)
Title: Journal of immunology (Baltimore, Md. : 1950)
Title(ISO): J Immunol
Publisher: American Association of Immunologists
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 183 [継承]
(必須): 8 [継承]
(必須): 5221 5231 [継承]
都市 (任意):
年月日 (必須): 西暦 2009年 9月 25日 (平成 21年 9月 25日) [継承]
URL (任意):
DOI (任意): 10.4049/jimmunol.0900768    (→Scopusで検索) [継承]
PMID (任意): 19783687    (→Scopusで検索) [継承]
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評価値 (任意):
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指導教員 (推奨):
備考 (任意): 1.(英) PublicationType: Journal Article  (日)    [継承]
2.(英) PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● (種別) : Jeroen Geurtsen, Sunita Chedammi, Joram Mesters, Marlène Cot, N Nicole Driessen, Tounkang Sambou, Ryo Kakutani, Roy Ummels, Janneke Maaskant, Hiroki Takata, Otto Baba, Tatsuo Terashima, Nicolai Bovin, E Christina M J Vandenbroucke-Grauls, Jérôme Nigou, Germain Puzo, Anne Lemassu, Mamadou Daffé and J Ben Appelmelk : Identification of mycobacterial alpha-glucan as a novel ligand for DC-SIGN: involvement of mycobacterial capsular polysaccharides in host immune modulation., The Journal of Immunology, Vol.183, No.8, 5221-5231, (発行所), (都市), Sep. 2009.
欧文冊子 ● (種別) : Jeroen Geurtsen, Sunita Chedammi, Joram Mesters, Marlène Cot, N Nicole Driessen, Tounkang Sambou, Ryo Kakutani, Roy Ummels, Janneke Maaskant, Hiroki Takata, Otto Baba, Tatsuo Terashima, Nicolai Bovin, E Christina M J Vandenbroucke-Grauls, Jérôme Nigou, Germain Puzo, Anne Lemassu, Mamadou Daffé and J Ben Appelmelk : Identification of mycobacterial alpha-glucan as a novel ligand for DC-SIGN: involvement of mycobacterial capsular polysaccharides in host immune modulation., The Journal of Immunology, Vol.183, No.8, 5221-5231, (発行所), (都市), Sep. 2009.

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