| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○カテゴリ (推奨): |
| ○共著種別 (推奨): | □ | 国内共著 (徳島大学内研究者と国内(学外)研究者との共同研究 (国外研究者を含まない))
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | 上村 浩一
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| 2. | 勝浦-釜野 桜子 ([徳島大学.大学院ヘルスバイオサイエンス研究部.医療創生科学部門.社会環境衛生学講座.予防医学]/->個人[釜野 桜子])
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| 3. | 山口 美輪
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| 4. | 有澤 孝吉 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.社会医学系.予防医学])
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| 5. | (英) Hamajima Nobuyuki (日) (読)
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| 6. | (英) Hishida Asahi (日) (読)
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| 7. | (英) Kawai Sayo (日) (読)
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| 8. | (英) Oze Isao (日) (読)
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| 9. | (英) Shinchi Koichi (日) (読)
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| 10. | (英) Takashima Naoyuki (日) (読)
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| 11. | (英) Suzuki Sadao (日) (読)
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| 12. | (英) Nakahata Noriko (日) (読)
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| 13. | (英) Mikami Haruo (日) (読)
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| 14. | (英) Ohnaka Keizo (日) (読)
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| 15. | (英) Kuriyama Nagato (日) (読)
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| 16. | (英) Kubo Michiaki (日) (読)
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| 17. | (英) Tanaka Hideo (日) (読)
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| ○題名 (必須): | □ | (英) A variant of the CLOCK gene and related haplotypes are associated with the prevalence of type 2 diabetes in the Japanese population. (日)
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| ○要約 (任意): | □ | (英) Circadian rhythm disruption is recognized as the cause of various health disorders. This study evaluated associations between single nucleotide polymorphisms in the core circadian gene, CLOCK, and prevalent type 2 diabetes in the Japanese population. We analyzed cross-sectional data from 2,485 subjects (1,243 men and 1,242 women; age, 35-69 years) who were enrolled in the baseline surveys of the Japan Multi-institutional Collaborative Cohort (J-MICC) Study. Associations between 3 CLOCK gene polymorphisms (rs1801260, rs3736544, and rs4864548) and prevalent obesity (BMI ≥25 kg/m(2) ), overweight (BMI ≥23 kg/m(2) ), and diabetes were evaluated by logistic regression analyses; haplotype analysis and stratified analyses for prevalent diabetes were also conducted. Compared to those who were homozygous for the respective major alleles, subjects with the rs1801260 minor allele C showed a significantly higher odds ratio (95% CI) of 1.5 (1.1-2.1) for prevalent diabetes, after adjustment for potential confounding factors, including BMI. When stratified by overweight, the associations between rs1801260 and prevalent diabetes were marked and significant in non-overweight subjects but were not significant in overweight subjects. The TGA (rs1801260 - rs3736544 - rs4864548) haplotype was associated with lower prevalence of diabetes, and the CGG haplotype was associated with higher prevalence of diabetes. CLOCK gene variants and related haplotypes are associated with prevalent type 2 diabetes in the Japanese population in whom obesity is less common, and the association between a CLOCK gene variants at rs1801260 and prevalent diabetes is enhanced in normal-build subjects. (日)
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| ○誌名 (必須): | □ | Journal of Diabetes (Ruijin yi yuan (Shanghai China))
(pISSN: 1753-0393, eISSN: 1753-0407)
| ○ISSN (任意): | □ | 1753-0407
ISSN: 1753-0393
(pISSN: 1753-0393, eISSN: 1753-0407) Title: Journal of diabetesTitle(ISO): J DiabetesSupplier: Chinese Society of EndocrinologyPublisher: Wiley Publishing (NLM Catalog)
(Wiley)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 8
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| ○号 (必須): | □ | 5
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| ○頁 (必須): | □ | 667 676
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| ○年月日 (必須): | □ | 西暦 2015年 9月 16日 (平成 27年 9月 16日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1111/1753-0407.12344 (→Scopusで検索)
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| ○PMID (任意): | □ | 26374515 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS (任意): | □ | 000383390500010
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| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1111/1753-0407.12344 (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: JOURNAL ARTICLE (日)
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| 3. | (英) KeywordList.Keyword: cross-sectional studies (日)
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| 4. | (英) KeywordList.Keyword: diabetes mellitus (日)
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| 5. | (英) KeywordList.Keyword: polymorphism (日)
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| 6. | (英) KeywordList.Keyword: single nucleotide (日)
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| 7. | (英) KeywordList.Keyword: type 2 (日)
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