『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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登録内容 (EID=306793)

EID=306793EID:306793, Map:0, LastModified:2016年9月6日(火) 17:23:51, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[松本 満], Read:継承, Write:継承, Delete:継承.
種別 (必須): 総説·解説 [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨): 1.疾患酵素学研究センター (2007年4月1日〜2016年3月31日/->組織[次世代酵素学研究領域]) [継承]
著者 (必須): 1.松本 満 ([徳島大学.先端酵素学研究所.重点研究部門])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Switching on the Aire conditioner  (日)    [継承]
副題 (任意):
要約 (任意): (英) Aire has been cloned as the gene responsible for a hereditary type of organ-specific autoimmune disease. Aire controls the expression of a wide array of tissue-restricted Ags by medullary thymic epithelial cells (mTECs), thereby leading to clonal deletion and Treg-cell production, and ultimately to the establishment of self-tolerance. However, relatively little is known about the mechanism responsible for the control of Aire expression itself. In this issue of the European Journal of Immunology, Haljasorg et al. [Eur. J. Immunol. 2015. 45: 3246-3256] have reported the presence of an enhancer element for Aire that binds with NF-κB components downstream of the TNF receptor family member, RANK (receptor activator of NF-κB). The results suggest that RANK has a dual mode of action in Aire expression: one involving the promotion of mTEC differentiation and the other involving activation of the molecular switch for Aire within mature mTECs.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Autoantigens (日) (読) [継承]
3.細胞分化 (cell differentiation) [継承]
4. (英) Epithelial Cells (日) (読) [継承]
5. (英) Gene Expression Regulation, Developmental (日) (読) [継承]
6. (英) Humans (日) (読) [継承]
7. (英) Mice (日) (読) [継承]
8. (英) Self Tolerance (日) (読) [継承]
9. (英) Thymus Gland (日) (読) [継承]
10. (英) Transcription Factors (日) (読) [継承]
発行所 (推奨):
誌名 (必須): European Journal of Immunology (European Federation of Immunological Societies)
(pISSN: 0014-2980, eISSN: 1521-4141)

ISSN (任意): 1521-4141
ISSN: 0014-2980 (pISSN: 0014-2980, eISSN: 1521-4141)
Title: European journal of immunology
Title(ISO): Eur J Immunol
Supplier: European Federation of Immunological Societies
Publisher: Wiley
 (NLM Catalog  (Wiley  (Scopus  (CrossRef (Scopus information is found. [need login])
[継承]
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(必須): 45 [継承]
(必須): 12 [継承]
(必須): 3237 3240 [継承]
都市 (任意):
年月日 (必須): 西暦 2015年 12月 初日 (平成 27年 12月 初日) [継承]
URL (任意):
DOI (任意): 10.1002/eji.201546098    (→Scopusで検索) [継承]
PMID (任意): 26643138    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意): 000366402000005 [継承]
Scopus (任意): 2-s2.0-84951747249 [継承]
評価値 (任意):
被引用数 (任意):
指導教員 (推奨):
備考 (任意): 1.(英) Article.ELocationID: 10.1002/eji.201041024  (日)    [継承]
2.(英) Article.Affiliation: Division of Molecular Immunology, Institute for Enzyme Research, University of Tokushima, Tokushima, Japan. mitsuru@ier.tokushima-u.ac.jp  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
4.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]
5.(英) Article.PublicationTypeList.PublicationType: Review  (日)    [継承]

標準的な表示

和文冊子 ● Mitsuru Matsumoto : Switching on the Aire conditioner, European Journal of Immunology, Vol.45, No.12, 3237-3240, Dec. 2015.
欧文冊子 ● Mitsuru Matsumoto : Switching on the Aire conditioner, European Journal of Immunology, Vol.45, No.12, 3237-3240, Dec. 2015.

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