『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=306733EID:306733, Map:0, LastModified:2016年4月18日(月) 14:16:11, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[齋藤 雅子], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1.齋藤 雅子 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.生体防御医学])
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[継承]
2. (英) Nagasawa Masayuki (日) (読)
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[継承]
3. (英) Takada Hidetoshi (日) (読)
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[継承]
4. (英) Hara Toshiro (日) (読)
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[継承]
5. (英) Tsuchiya Shigeru (日) (読)
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[継承]
6. (英) Agematsu Kazunaga (日) (読)
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[継承]
7. (英) Yamada Masafumi (日) (読)
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[継承]
8. (英) Kawamura Nobuaki (日) (読)
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[継承]
9. (英) Ariga Tadashi (日) (読)
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学籍番号 (推奨):
[継承]
10. (英) Tsuge Ikuya (日) (読)
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[継承]
11. (英) Nonoyama Shigeaki (日) (読)
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[継承]
12. (英) Karasuyama Hajime (日) (読)
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[継承]
13.峯岸 克行 ([徳島大学.先端酵素学研究所.重点研究部門])
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貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Defective IL-10 signaling in hyper-IgE syndrome results in impaired generation of tolerogenic dendritic cells and induced regulatory T cells.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Hyper-IgE syndrome (HIES) is a primary immunodeficiency characterized by recurrent staphylococcal infections and atopic dermatitis associated with elevated serum IgE levels. Although defective differentiation of IL-17-producing CD4(+) T cells (Th17) partly accounts for the susceptibility to staphylococcal skin abscesses and pneumonia, the pathogenesis of atopic manifestations in HIES still remains an enigma. In this study, we examined the differentiation and function of Th1, Th2, regulatory T cells (T(reg) cells), and dendritic cells (DCs) in HIES patients carrying either STAT3 or TYK2 mutations. Although the in vitro differentiation of Th1 and Th2 cells and the number and function of T(reg) cells in the peripheral blood were normal in HIES patients with STAT3 mutations, primary and monocyte-derived DCs showed defective responses to IL-10 and thus failed to become tolerogenic. When treated with IL-10, patient DCs showed impaired up-regulation of inhibitory molecules on their surface, including PD-L1 and ILT-4, compared with control DCs. Moreover, IL-10-treated DCs from patients displayed impaired ability to induce the differentiation of naive CD4(+) T cells to FOXP3(+) induced T(reg) cells (iT(reg) cells). These results suggest that the defective generation of IL-10-induced tolerogenic DCs and iT(reg) cells may contribute to inflammatory changes in HIES.  (日)    [継承]
キーワード (推奨): 1. (英) Antibodies, Monoclonal (日) (読) [継承]
2. (英) Antigens, CD (日) (読) [継承]
3. (英) Antigens, CD274 (日) (読) [継承]
4. (英) Cell Differentiation (日) (読) [継承]
5. (英) Cytokines (日) (読) [継承]
6. (英) Dendritic Cells (日) (読) [継承]
7. (英) Flow Cytometry (日) (読) [継承]
8. (英) Humans (日) (読) [継承]
9. (英) Immune Tolerance (日) (読) [継承]
10. (英) Interleukin-10 (日) (読) [継承]
11. (英) Job Syndrome (日) (読) [継承]
12. (英) Membrane Glycoproteins (日) (読) [継承]
13. (英) Mutation (日) (読) [継承]
14. (英) Receptors, Immunologic (日) (読) [継承]
15. (英) Reverse Transcriptase Polymerase Chain Reaction (日) (読) [継承]
16. (英) STAT3 Transcription Factor (日) (読) [継承]
17. (英) Signal Transduction (日) (読) [継承]
18. (英) T-Lymphocytes, Regulatory (日) (読) [継承]
19. (英) TYK2 Kinase (日) (読) [継承]
発行所 (推奨):
誌名 (必須): The Journal of Experimental Medicine ([The Rockefeller University Press])
(pISSN: 0022-1007, eISSN: 1540-9538)

ISSN (任意): 1540-9538
ISSN: 0022-1007 (pISSN: 0022-1007, eISSN: 1540-9538)
Title: The Journal of experimental medicine
Title(ISO): J Exp Med
Publisher: Rockefeller University Press
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 208 [継承]
(必須): 2 [継承]
(必須): 235 249 [継承]
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年月日 (必須): 西暦 2011年 2月 7日 (平成 23年 2月 7日) [継承]
URL (任意):
DOI (任意): 10.1084/jem.20100799    (→Scopusで検索) [継承]
PMID (任意): 21300911    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) PublicationType: Journal Article  (日)    [継承]
2.(英) PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Masako Saito, Masayuki Nagasawa, Hidetoshi Takada, Toshiro Hara, Shigeru Tsuchiya, Kazunaga Agematsu, Masafumi Yamada, Nobuaki Kawamura, Tadashi Ariga, Ikuya Tsuge, Shigeaki Nonoyama, Hajime Karasuyama and Yoshiyuki Minegishi : Defective IL-10 signaling in hyper-IgE syndrome results in impaired generation of tolerogenic dendritic cells and induced regulatory T cells., The Journal of Experimental Medicine, Vol.208, No.2, 235-249, 2011.
欧文冊子 ● Masako Saito, Masayuki Nagasawa, Hidetoshi Takada, Toshiro Hara, Shigeru Tsuchiya, Kazunaga Agematsu, Masafumi Yamada, Nobuaki Kawamura, Tadashi Ariga, Ikuya Tsuge, Shigeaki Nonoyama, Hajime Karasuyama and Yoshiyuki Minegishi : Defective IL-10 signaling in hyper-IgE syndrome results in impaired generation of tolerogenic dendritic cells and induced regulatory T cells., The Journal of Experimental Medicine, Vol.208, No.2, 235-249, 2011.

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