『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=306669EID:306669, Map:0, LastModified:2016年4月21日(木) 13:29:01, Operator:[三好 小文], Avail:TRUE, Censor:0, Owner:[田中 栄二], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨): 国際共著 (徳島大学内研究者と国外研究機関所属研究者との共同研究) [継承]
学究種別 (推奨): 博士課程学生による研究報告 [継承]
組織 (推奨): 1.徳島大学.口腔科学教育部.口腔科学専攻.口腔健康科学講座.口腔顎顔面矯正学 (2004年4月1日〜) [継承]
2.徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.口腔顎顔面矯正学 (2015年4月1日〜) [継承]
3.徳島大学.病院.診療科.矯正歯科 (2003年10月1日〜) [継承]
著者 (必須): 1.KARIMA QURNIA MANSJUR ([徳島大学.口腔科学教育部.口腔科学専攻.口腔健康科学講座.口腔顎顔面矯正学])
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2.黒田 晋吾
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3.井澤 俊
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4.前田 有一 ([徳島大学.口腔科学教育部.口腔科学専攻.口腔健康科学講座.口腔顎顔面矯正学])
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5.佐藤 南 ([徳島大学.口腔科学教育部.口腔科学専攻.口腔健康科学講座.口腔顎顔面矯正学])
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6.渡邉 佳一郎 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.口腔顎顔面矯正学]/[徳島大学.病院.診療科.矯正歯科])
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7.堀内 信也 ([徳島大学.病院.診療科.矯正歯科])
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8.田中 栄二 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.口腔顎顔面矯正学])
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[継承]
題名 (必須): (英) The Effectiveness of Human Parathyroid Hormone and Low-Intensity Pulsed Ultrasound on the Fracture Healing in Osteoporotic Bones.  (日)    [継承]
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要約 (任意): (英)   (日) Osteoporotic fracture has become a major public health problem, and until today, the treatments available are not satisfactory. While there is growing evidence to support the individual treatment of parathyroid hormone (PTH) administration and low-intensity pulsed ultrasound (LIPUS) exposure as respectively systemic and local therapies during osteoporotic fracture healing, their effects have not yet been investigated when introduced concurrently. This study aimed to evaluate the effects of combined treatment with PTH (1-34) and LIPUS on fracture healing in ovariectomized (OVX) rats. Thirty-two, 12-week-old female Sprague-Dawley rats were OVX to induce osteoporosis. After 12 weeks, the rats underwent surgery to create bilateral mid-diaphyseal fractures of proximal tibiae. All animals were randomly divided into 4 groups (n = 8 for each): control group as placebo, PTH group, LIPUS group, and combined group. PTH group had PTH administration at a dose of 30 μg/kg/day for 3 days/week for 6 weeks. LIPUS group received ultrasound 5 days/week for 20 min/day for 6 weeks and combined group had both PTH administration and LIPUS exposure for 6 weeks. Fracture healing was observed weekly by anteroposterior radiography and micro-CT. Five weeks after the fracture, the tibia were harvested to permit histological assessments and at week 6, for mechanical property of the fracture callus. Micro-CT showed that the PTH and combined groups exhibited significantly higher BMD and trabecular bone integrity than control group at weeks 4-6. Radiography, fracture healing score and mean callus area indicated that the combined group revealed better healing processes than the individual groups. Mechanically, bending moment to failure was significantly higher in LIPUS, PTH and combined groups than in control group. These data suggest that the combined treatment of PTH and LIPUS have been shown to accelerate fracture bone healing and enhance bone properties rather than single agent therapy, and may be considered as a treatment remedy for fracture healing in postmenopausal osteoporosis.   [継承]
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誌名 (必須): Annals of Biomedical Engineering (Biomedical Engineering Society (BMES).)
(pISSN: 0090-6964, eISSN: 1573-9686)

ISSN (任意): 1573-9686
ISSN: 0090-6964 (pISSN: 0090-6964, eISSN: 1573-9686)
Title: Annals of biomedical engineering
Title(ISO): Ann Biomed Eng
Supplier: Kluwer Online
Publisher: Springer US
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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年月日 (必須): 西暦 2016年 1月 21日 (平成 28年 1月 21日) [継承]
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DOI (任意): 10.1007/s10439-015-1533-y    (→Scopusで検索) [継承]
PMID (任意): 26795976    (→Scopusで検索) [継承]
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Scopus (任意): 2-s2.0-84955254616 [継承]
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備考 (任意): 1.(英) PublicationType: JOURNAL ARTICLE  (日)    [継承]

標準的な表示

和文冊子 ● MANSJUR KARIMA QURNIA, Shingo Kuroda, Takashi Izawa, Yuichi Maeda, Minami Sato, Keiichiro Watanabe, Shinya Horiuchi and Eiji Tanaka : The Effectiveness of Human Parathyroid Hormone and Low-Intensity Pulsed Ultrasound on the Fracture Healing in Osteoporotic Bones., Annals of Biomedical Engineering, (巻), (号), (頁), 2016.
欧文冊子 ● MANSJUR KARIMA QURNIA, Shingo Kuroda, Takashi Izawa, Yuichi Maeda, Minami Sato, Keiichiro Watanabe, Shinya Horiuchi and Eiji Tanaka : The Effectiveness of Human Parathyroid Hormone and Low-Intensity Pulsed Ultrasound on the Fracture Healing in Osteoporotic Bones., Annals of Biomedical Engineering, (巻), (号), (頁), 2016.

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