| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○組織 (推奨): |
| ○著者 (必須): | 1. | 仁木 敏之
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| 2. | 若槻 哲三 ([徳島大学.大学院医歯薬学研究部.医学域.先端医学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.循環器内科学]/[徳島大学.病院.診療科.内科.循環器内科])
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| 3. | 山口 浩司 ([徳島大学.病院.先端医科医療開発研究プロジェクト]/[徳島大学.病院.診療科.内科.循環器内科])
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| 4. | 竹谷 善雄
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| 5. | (英) Oeduka Hiroyasu (日) (読)
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| 6. | 楠瀬 賢也
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| 7. | 伊勢 孝之 ([徳島大学.病院.診療科.内科.循環器内科])
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| 8. | 岩瀬 俊
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| 9. | 山田 博胤 ([徳島大学.大学院医歯薬学研究部.医学域.連携研究部門(医学域).寄附講座系(医学域).地域循環器内科学])
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| 10. | 添木 武 ([徳島大学.大学院医歯薬学研究部.医学域.連携研究部門(医学域).寄附講座系(医学域).実践地域診療・医科学])
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| 11. | 佐田 政隆 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.循環器内科学])
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| ○題名 (必須): | □ | (英) Effects of the addition of eicosapentaenoic acid to strong statin therapy on inflammatory cytokines and coronary plaque components assessed by integrated backscatter intravascular ultrasound. (日)
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| ○要約 (任意): | □ | (英) BACKGROUND: The effects of eicosapentaenoic acid (EPA) on coronary artery disease have been previously reported; however, those of the addition of EPA to strong statins on coronary plaque components and local inflammatory cytokines are not known.METHODSANDRESULTS: A total of 95 patients who had been treated with strong statin for at least 6 months were randomized into 2 groups: an EPA group (additional treatment with EPA at 1,800 mg/day, n=48) or a control group (no additional treatment, n=47), for 6 months. The tissue characteristics of target coronary plaque in each patient were analyzed using IB-IVUS before and after treatment. We also measured plasma levels of inflammatory cytokines sampled in the coronary sinus (CS) and peripheral vein.A significant reduction in lipid volume (18.5±1.3 to 15.0±1.5 mm(3), P=0.007) and a significant increase in fibrous volume (22.9±0.8 to 25.6±1.1 mm(3), P=0.01) were observed in IB-IVUS image analyses in the EPA group, but no significant changes in the plaque components in the control group. CS levels of pentraxin 3 and monocyte chemoattractant protein-1 were lower after than before treatment with EPA (3.3±2.1 to 2.6±1.2 ng/ml, 120.4±26.2 to 110.2±26.8 pg/ml, P=0.015 and P=0.008, respectively); however, there were no significant changes in those inflammatory cytokines between pre- and post-treatment in the control group.CONCLUSIONS: The addition of EPA was associated with reduced lipid volume in coronary plaques and decreased inflammatory cytokines. (Circ J 2016; 80: 450-460). (日)
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| ○キーワード (推奨): | 1. | (英) Coronary plaque (日) (読)
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| 2. | (英) Eicosapentaenoic acid (日) (読)
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| 3. | (英) Inflammatory cytokines (日) (読)
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| 4. | (英) Integrated backscatter intravascular ultrasound (日) (読)
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| 5. | (英) Strong statins (日) (読)
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| ○発行所 (推奨): | □ | 社団法人 日本循環器学会
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| ○誌名 (必須): | □ | Circulation Journal ([社団法人 日本循環器学会])
(pISSN: 1346-9843, eISSN: 1347-4820)
| ○ISSN (任意): | □ | 1347-4820
ISSN: 1346-9843
(pISSN: 1346-9843, eISSN: 1347-4820) Title: Circulation journal : official journal of the Japanese Circulation SocietyTitle(ISO): Circ JSupplier: 社団法人日本循環器学会Publisher: Japanese Circulation Society (NLM Catalog)
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(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 80
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| ○号 (必須): | □ | 2
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| ○頁 (必須): | □ | 450 460
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2016年 1月 25日 (平成 28年 1月 25日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1253/circj.CJ-15-0813 (→Scopusで検索)
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| ○PMID (任意): | □ | 26667367 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS (任意): | □ | 000369376900028
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| ○Scopus (任意): | □ | 2-s2.0-84955453337
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| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1253/circj.CJ-15-0813 (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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