『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨): 単独著作 (徳島大学内の単一の研究グループ(研究室等)内の研究 (単著も含む)) [継承]
学究種別 (推奨):
組織 (推奨): 1.疾患酵素学研究センター (2007年4月1日〜2016年3月31日/->組織[徳島大学.先端酵素学研究所.次世代酵素学研究領域]) [継承]
著者 (必須): 1. (英) Tran Hong Diem (日) (読)
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2.宍戸 裕二 ([徳島大学.先端酵素学研究所.次世代酵素学研究領域])
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3.鄭 丞弼
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4. (英) Trinh Thi Thanh Huong (日) Trinh Thi Thanh Huong (読) とりん てぃ たん ふん
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学籍番号 (推奨): **** [ユーザ]
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5.頼田 和子
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6.坂井 隆志
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7.福井 清 ([徳島大学])
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題名 (必須): (英) Identification of DNA-binding proteins that interact with the 5-flanking region of the human d-amino acid oxidase gene by pull-down assay coupled with two-dimensional gel electrophoresis and mass spectrometry  (日)    [継承]
副題 (任意):
要約 (任意): (英) d-Amino acid oxidase (DAO) is a flavoenzyme that metabolizes d-amino acids and is expected to be a promising therapeutic target of schizophrenia and glioblastoma. The study of DNA-binding proteins has yielded much information in the regulation of transcription and other biological processes. However, proteins interacting with DAO gene have not been elucidated. Our assessment of human DAO promoter activity using luciferase reporter system indicated the 5'-flanking region of this gene (-4289bp from transcription initiation site) has a regulatory sequence for gene expression, which is regulated by multi-protein complexes interacting with this region. By using pull-down assay coupled with two-dimensional gel electrophoresis and mass spectrometry, we identified six proteins binding to the 5'-flanking region of the human DAO gene (zinc finger C2HC domain-containing protein 1A; histidine-tRNA ligase, cytoplasmic; molybdenum cofactor biosynthesis protein; 60S ribosomal protein L37; calponin-1; calmodulin binding protein and heterogeneous nuclear ribonucleoprotein A2/B1). These preliminary results will contribute to the advance in the understanding of the potential factors associated with the regulatory mechanism of DAO expression.  (日)    [継承]
キーワード (推奨):
発行所 (推奨): Elsevier Science B.V. [継承]
誌名 (必須): Journal of Pharmaceutical and Biomedical Analysis (American Association of Pharmaceutical Scientists)
(pISSN: 0731-7085, eISSN: 1873-264X)

ISSN (任意): 1873-264X
ISSN: 0731-7085 (pISSN: 0731-7085, eISSN: 1873-264X)
Title: Journal of pharmaceutical and biomedical analysis
Title(ISO): J Pharm Biomed Anal
Publisher: Elsevier BV
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都市 (任意): アムステルダム (Amsterdam/[オランダ王国]) [継承]
年月日 (必須): 西暦 2015年 12月 10日 (平成 27年 12月 10日) [継承]
URL (任意):
DOI (任意): 10.1016/j.jpba.2015.02.031    (→Scopusで検索) [継承]
PMID (任意): 25749303    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.ELocationID: 10.1016/j.jpba.2015.02.031  (日)    [継承]
2.(英) Article.ELocationID: S0731-7085(15)00127-2  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
4.(英) KeywordList.Keyword: 5'-Flanking region  (日)    [継承]
5.(英) KeywordList.Keyword: DNA-binding protein  (日)    [継承]
6.(英) KeywordList.Keyword: Mass spectrometry  (日)    [継承]
7.(英) KeywordList.Keyword: Pull-down assay  (日)    [継承]
8.(英) KeywordList.Keyword: d-Amino acid oxidase  (日)    [継承]

標準的な表示

和文冊子 ● Diem Hong Tran, Yuji Shishido, Seongpil Chung, Huong Thi Thanh Trinh, Kazuko YORITA, Takashi Sakai and Kiyoshi Fukui : Identification of DNA-binding proteins that interact with the 5-flanking region of the human d-amino acid oxidase gene by pull-down assay coupled with two-dimensional gel electrophoresis and mass spectrometry, Journal of Pharmaceutical and Biomedical Analysis, Vol.116, 94-100, 2015.
欧文冊子 ● Diem Hong Tran, Yuji Shishido, Seongpil Chung, Huong Thi Thanh Trinh, Kazuko YORITA, Takashi Sakai and Kiyoshi Fukui : Identification of DNA-binding proteins that interact with the 5-flanking region of the human d-amino acid oxidase gene by pull-down assay coupled with two-dimensional gel electrophoresis and mass spectrometry, Journal of Pharmaceutical and Biomedical Analysis, Vol.116, 94-100, 2015.

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