『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Kato Y (日) (読)
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[継承]
2. (英) Yokoyama U (日) (読)
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[継承]
3. (英) Yanai C (日) (読)
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[継承]
4. (英) Ishige R (日) (読)
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[継承]
5. (英) Kurotaki D (日) (読)
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[継承]
6. (英) Umemura M (日) (読)
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[継承]
7. (英) Fujita T (日) (読)
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[継承]
8. (英) Kubota T (日) (読)
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[継承]
9. (英) Okumura S (日) (読)
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[継承]
10.佐田 政隆 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.循環器内科学])
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11. (英) Tamura T (日) (読)
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[継承]
12. (英) Ishikawa Y (日) (読)
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[継承]
題名 (必須): (英) Epac1 Deficiency Attenuated Vascular Smooth Muscle Cell Migration and Neointimal Formation.  (日)    [継承]
副題 (任意):
要約 (任意): (英) OBJECTIVE: Vascular smooth muscle cell (SMC) migration causes neointima, which is related to vascular remodeling after mechanical injury and atherosclerosis development. We previously reported that an exchange protein activated by cAMP (Epac) 1 was upregulated in mouse arterial neointima and promoted SMC migration. In this study, we examined the molecular mechanisms of Epac1-induced SMC migration and the effect of Epac1 deficiency on vascular remodeling in vivo.APPROACH AND RESULTS: Platelet-derived growth factor-BB promoted a 2-fold increase in SMC migration in a primary culture of aortic SMCs obtained from Epac1+/+ mice (Epac1+/+-ASMCs), whereas there was only a 1.2-fold increase in Epac1-/--ASMCs. The degree of platelet-derived growth factor-BB-induced increase in intracellular Ca2+ was smaller in Fura2-labeled Epac1-/--ASMCs than in Epac1+/+-ASMCs. In Epac1+/+-ASMCs, an Epac-selective cAMP analog or platelet-derived growth factor-BB increased lamellipodia accompanied by cofilin dephosphorylation, which is induced by Ca2+ signaling, whereas these effects were rarely observed in Epac1-/--ASMCs. Furthermore, 4 weeks after femoral artery injury, prominent neointima were formed in Epac1+/+ mice, whereas neointima formation was significantly attenuated in Epac1-/- mice in which dephosphorylation of cofilin was inhibited. The chimeric mice generated by bone marrow cell transplantation from Epac1+/+ into Epac1-/- mice and vice versa demonstrated that the genetic background of vascular tissues, including SMCs rather than of bone marrow-derived cells affected Epac1-mediated neointima formation.CONCLUSIONS: These data suggest that Epac1 deficiency attenuates neointima formation through, at least in part, inhibition of SMC migration, in which a decrease in Ca2+ influx and a suppression of cofilin-mediated lamellipodia formation occur.  (日)    [継承]
キーワード (推奨): 1. (英) arterial injury (日) (読) [継承]
2. (英) intima-media thickness (日) (読) [継承]
3. (英) migration (日) (読) [継承]
4.シグナル伝達 (signal transduction) [継承]
5. (英) vascular smooth muscle (日) (読) [継承]
発行所 (推奨): American Heart Association [継承]
誌名 (必須): Arteriosclerosis, Thrombosis, and Vascular Biology ([American Heart Association])
(pISSN: 1079-5642, eISSN: 1524-4636)

ISSN (任意): 1524-4636
ISSN: 1079-5642 (pISSN: 1079-5642, eISSN: 1524-4636)
Title: Arteriosclerosis, thrombosis, and vascular biology
Title(ISO): Arterioscler. Thromb. Vasc. Biol.
Publisher: American Heart Association
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 35 [継承]
(必須): 12 [継承]
(必須): 2617 2625 [継承]
都市 (任意): ダラス (Dallas/[アメリカ合衆国]) [継承]
年月日 (必須): 西暦 2015年 12月 初日 (平成 27年 12月 初日) [継承]
URL (任意):
DOI (任意): 10.1161/ATVBAHA.115.306534    (→Scopusで検索) [継承]
PMID (任意): 26427796    (→Scopusで検索) [継承]
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Scopus (任意): 2-s2.0-84948111930 [継承]
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備考 (任意): 1.(英) Article.ELocationID: 10.1161/ATVBAHA.115.306534  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]
4.(英) KeywordList.Keyword: arterial injury  (日)    [継承]
5.(英) KeywordList.Keyword: intima-media thickness  (日)    [継承]
6.(英) KeywordList.Keyword: migration  (日)    [継承]
7.(英) KeywordList.Keyword: signal transduction  (日)    [継承]
8.(英) KeywordList.Keyword: vascular smooth muscle  (日)    [継承]

標準的な表示

和文冊子 ● Y Kato, U Yokoyama, C Yanai, R Ishige, D Kurotaki, M Umemura, T Fujita, T Kubota, S Okumura, Masataka Sata, T Tamura and Y Ishikawa : Epac1 Deficiency Attenuated Vascular Smooth Muscle Cell Migration and Neointimal Formation., Arteriosclerosis, Thrombosis, and Vascular Biology, Vol.35, No.12, 2617-2625, 2015.
欧文冊子 ● Y Kato, U Yokoyama, C Yanai, R Ishige, D Kurotaki, M Umemura, T Fujita, T Kubota, S Okumura, Masataka Sata, T Tamura and Y Ishikawa : Epac1 Deficiency Attenuated Vascular Smooth Muscle Cell Migration and Neointimal Formation., Arteriosclerosis, Thrombosis, and Vascular Biology, Vol.35, No.12, 2617-2625, 2015.

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